INT69000

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Context Info
Confidence 0.20
First Reported 1996
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 6
Total Number 8
Disease Relevance 5.87
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PROC) extracellular space (PROC) extracellular region (PROC)
plasma membrane (PROC)
Anatomy Link Frequency
pancreas 2
finger 2
plaques 2
striatum 2
PROC (Homo sapiens)
Pain Link Frequency Relevance Heat
Dynorphin 11 100.00 Very High Very High Very High
Inflammation 9 99.36 Very High Very High Very High
Chronic pancreatitis 6 97.28 Very High Very High Very High
cytokine 6 96.76 Very High Very High Very High
antagonist 3 96.32 Very High Very High Very High
fibrosis 1 93.80 High High
Angina 2 93.20 High High
Pain 3 92.76 High High
metalloproteinase 1 80.08 Quite High
alcohol 1 77.92 Quite High
Disease Link Frequency Relevance Heat
Infection 2 100.00 Very High Very High Very High
Atherosclerotic Plaque 4 99.98 Very High Very High Very High
Hepatitis C Virus Infection 6 99.86 Very High Very High Very High
Osteoporosis 5 99.60 Very High Very High Very High
INFLAMMATION 9 99.36 Very High Very High Very High
Cancer 8 99.24 Very High Very High Very High
Osteosclerosis 14 98.20 Very High Very High Very High
Congenital Anomalies 2 97.80 Very High Very High Very High
Atherosclerosis 16 97.60 Very High Very High Very High
Pancreatitis 6 97.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Infiltration of the pancreas by particular subsets of immune effector cells, aberrant and enhanced expression of MHC molecules, and overexpression of growth factors and their receptors have all recently been found to play a role in CP.
Positive_regulation (overexpression) of Gene_expression (overexpression) of factors in pancreas associated with chronic pancreatitis
1) Confidence 0.20 Published 2001 Journal Zentralbl Chir Section Abstract Doc Link 11753795 Disease Relevance 0.75 Pain Relevance 0.58
Increased osteoclastic activity, in turn, leads to production of a variety of lymphokines and growth factors that can increase tumor cell proliferation.
Positive_regulation (leads) of Gene_expression (production) of factors associated with cancer and osteoporosis
2) Confidence 0.20 Published 2007 Journal Clin. Breast Cancer Section Abstract Doc Link 17683652 Disease Relevance 1.43 Pain Relevance 0.17
The ratio of ratio of PC per apoE at apoE concentrations of 0.1,1,10, and 30 ?
Positive_regulation (at) of Gene_expression (per) of PC
3) Confidence 0.03 Published 2007 Journal Mol Neurodegener Section Body Doc Link PMC1876452 Disease Relevance 0.11 Pain Relevance 0
To the best of our knowledge, this is the first report on the highly significant increased expression of the zinc finger KRAB domain-containing transcription factors in circulating CD34+ cells (129 in total).
Positive_regulation (increased) of Gene_expression (expression) of factors in finger
4) Confidence 0.01 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2901320 Disease Relevance 0.09 Pain Relevance 0
Local inflammation of the atherosclerotic plaques induces the expression of a number of growth factors and other potent molecules that contribute to vascular remodeling.
Positive_regulation (induces) of Gene_expression (expression) of factors in plaques associated with atherosclerotic plaque and inflammation
5) Confidence 0.00 Published 2001 Journal Herz Section Abstract Doc Link 11349622 Disease Relevance 1.18 Pain Relevance 0.38
HCV might induce a slow bone cell infection and the production of bone growth factors, such as insulin-like growth factors.
Spec (might) Positive_regulation (induce) of Gene_expression (production) of factors associated with hepatitis c virus infection and infection
6) Confidence 0.00 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15583970 Disease Relevance 1.15 Pain Relevance 0.14
HCV might induce a slow bone cell infection and the production of bone growth factors, such as insulin-like growth factors.
Spec (might) Positive_regulation (induce) of Gene_expression (production) of factors associated with hepatitis c virus infection and infection
7) Confidence 0.00 Published 2005 Journal Clin. Rheumatol. Section Abstract Doc Link 15583970 Disease Relevance 1.15 Pain Relevance 0.13
These data indicate that stimulant drugs such as METH increase the expression of DYN and AP-1 factors in the striatum via a D1 receptor-mediated mechanism.
Positive_regulation (increase) of Gene_expression (expression) of factors in striatum associated with dynorphin
8) Confidence 0.00 Published 1996 Journal Biol. Signals Section Abstract Doc Link 9116798 Disease Relevance 0 Pain Relevance 0.44

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