INT69009

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Context Info
Confidence 0.27
First Reported 1995
Last Reported 2009
Negated 5
Speculated 0
Reported most in Abstract
Documents 9
Total Number 13
Disease Relevance 9.86
Pain Relevance 2.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Nfkb1) signal transduction (Nfkb1) mitochondrion (Nfkb1)
nucleus (Nfkb1) DNA binding (Nfkb1) nucleic acid binding transcription factor activity (Nfkb1)
Anatomy Link Frequency
muscles 2
Nfkb1 (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 6 99.66 Very High Very High Very High
Paracetamol 12 99.02 Very High Very High Very High
Analgesic 10 98.66 Very High Very High Very High
Inflammation 55 98.38 Very High Very High Very High
local anesthetic 2 82.12 Quite High
anesthesia 6 75.08 Quite High
ketamine 1 74.28 Quite High
Inflammatory mediators 14 68.80 Quite High
COX2 3 25.00 Low Low
cytokine 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hemophilus Infection 445 99.50 Very High Very High Very High
Hepatotoxicity 6 99.48 Very High Very High Very High
INFLAMMATION 78 98.38 Very High Very High Very High
Apoptosis 13 98.00 Very High Very High Very High
Nociception 3 97.58 Very High Very High Very High
Emphysema 2 95.60 Very High Very High Very High
Adhesions 2 93.48 High High
Breast Cancer 2 93.20 High High
Infection 60 89.32 High High
Muscular Atrophy 2 89.12 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EMSA analysis showed that NF-kappa B translocation and its DNA binding activity were markedly increased by NTHi within 90 mins, and DNA binding activity of NF-kappa B was not affected by pre-treatment of specific p38 MAPK inhibitor SB203580.
Neg (not) Regulation (affected) of NF-kappa B Binding (activity) of associated with hemophilus infection
1) Confidence 0.27 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.17 Pain Relevance 0
Acetaminophen-induced hepatotoxicity is associated with early changes in NF-kB and NF-IL6 DNA binding activity.
Regulation (changes) of NF-kB Binding (activity) of associated with paracetamol and hepatotoxicity
2) Confidence 0.26 Published 1995-1996 Journal J. Inflamm. Section Title Doc Link 9117441 Disease Relevance 0.39 Pain Relevance 0.54
Acetaminophen-induced hepatotoxicity is associated with early changes in NF-kB and NF-IL6 DNA binding activity.
Regulation (changes) of NF-kB Binding (binding) of associated with paracetamol and hepatotoxicity
3) Confidence 0.26 Published 1995-1996 Journal J. Inflamm. Section Title Doc Link 9117441 Disease Relevance 0.39 Pain Relevance 0.54
The aqueous extract of corni fructus exerts anti-inflammatory and analgesic effects by suppressing COX-2 and iNOS expression through the down-regulation of NF-kappaB binding activity.
Regulation (regulation) of NF-kappaB Binding (activity) of associated with inflammation and analgesic
4) Confidence 0.25 Published 2009 Journal J Med Food Section Abstract Doc Link 19735178 Disease Relevance 0.29 Pain Relevance 0.51
These findings suggest that the anti-inflammatory and anti-nociceptive properties of the methanol extract of MEFF may result from the inhibition of iNOS and COX-2 expression through the down-regulation of NF-kappaB binding activity.
Regulation (regulation) of NF-kappaB Binding (activity) of associated with nociception and inflammation
5) Confidence 0.22 Published 2004 Journal Biol. Pharm. Bull. Section Abstract Doc Link 15467201 Disease Relevance 0.80 Pain Relevance 0.24
It downregulated phosphorylation of p65 by inhibiting upstream kinases, such as protein kinase A and casein kinase II, but did not alter NF-kappaB DNA-binding activity.
Neg (not) Regulation (alter) of NF-kappaB Binding (binding) of
6) Confidence 0.20 Published 2007 Journal Cell Death Differ. Section Abstract Doc Link 16645640 Disease Relevance 0.51 Pain Relevance 0.08
It downregulated phosphorylation of p65 by inhibiting upstream kinases, such as protein kinase A and casein kinase II, but did not alter NF-kappaB DNA-binding activity.
Neg (not) Regulation (alter) of NF-kappaB Binding (activity) of
7) Confidence 0.20 Published 2007 Journal Cell Death Differ. Section Abstract Doc Link 16645640 Disease Relevance 0.51 Pain Relevance 0.08
CPS itself does not affect the DNA-binding ability of NF-kappaB but it prevents IkappaB kinase activation and IkappaBalpha degradation in a dose-dependent manner, without inhibiting the activation of the mitogen-activated protein kinases, p38, extracellular regulated kinase and c-Jun N-terminal protein kinase.
Neg (not) Regulation (affect) of NF-kappaB Binding (ability) of associated with qutenza
8) Confidence 0.12 Published 2002 Journal Eur. J. Immunol. Section Abstract Doc Link 12115659 Disease Relevance 0.22 Pain Relevance 0.48
NTHi induced phosphorylation of p38 MAPK and up-regulated DNA binding activity of NF-kappa B.
Regulation (-) of NF-kappa B Binding (binding) of associated with hemophilus infection
9) Confidence 0.12 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2270828 Disease Relevance 1.13 Pain Relevance 0
EMSA analysis showed that NF-kappa B translocation and its DNA binding activity were markedly increased by NTHi within 90 mins, and DNA binding activity of NF-kappa B was not affected by pre-treatment of specific p38 MAPK inhibitor SB203580.
Neg (not) Regulation (affected) of NF-kappa B Binding (binding) of associated with hemophilus infection
10) Confidence 0.12 Published 2008 Journal Respir Res Section Body Doc Link PMC2270828 Disease Relevance 1.17 Pain Relevance 0
NTHi induced phosphorylation of p38 MAPK and up-regulated DNA binding activity of NF-kappa B.
Regulation (regulated) of NF-kappa B Binding (binding) of associated with hemophilus infection
11) Confidence 0.12 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2270828 Disease Relevance 1.13 Pain Relevance 0
NTHi induced phosphorylation of p38 MAPK and up-regulated DNA binding activity of NF-kappa B.
Regulation (-) of NF-kappa B Binding (activity) of associated with hemophilus infection
12) Confidence 0.12 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2270828 Disease Relevance 1.13 Pain Relevance 0
Caspase 3 activity and the DNA-binding activity of the p65 subunit of NF-kappaB, however, were unaltered in all muscles.
Regulation (unaltered) of NF-kappaB Binding (binding) of in muscles
13) Confidence 0.02 Published 2007 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 17395785 Disease Relevance 1.01 Pain Relevance 0.11

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