INT69020

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Context Info
Confidence 0.74
First Reported 1997
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 6.09
Pain Relevance 2.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Htr2c) plasma membrane (Htr2c) nucleus (Htr2c)
cytoplasm (Htr2c) signal transducer activity (Htr2c)
Anatomy Link Frequency
ADAR 1
central nervous system 1
oocytes 1
Htr2c (Mus musculus)
Pain Link Frequency Relevance Heat
Serotonin 72 100.00 Very High Very High Very High
opioid receptor 2 97.28 Very High Very High Very High
Kinase C 4 96.72 Very High Very High Very High
sSRI 68 95.88 Very High Very High Very High
Delta opioid receptors 1 95.76 Very High Very High Very High
agonist 27 95.52 Very High Very High Very High
Central nervous system 6 93.96 High High
MU agonist 1 88.56 High High
addiction 4 87.52 High High
depression 11 86.24 High High
Disease Link Frequency Relevance Heat
Stress 19 99.52 Very High Very High Very High
Convulsion 172 99.40 Very High Very High Very High
Anxiety Disorder 422 98.76 Very High Very High Very High
Obesity 8 94.20 High High
Attention Deficit Hyperactivity Disorder 26 93.28 High High
Aggression 4 93.24 High High
Bordatella Infection 1 92.52 High High
Sprains And Strains 34 92.24 High High
Neurodegenerative Disease 7 90.20 High High
Weight Gain 6 89.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, because Htr2c expression is reduced only modestly (?
Gene_expression (expression) of Htr2c
1) Confidence 0.74 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.64 Pain Relevance 0.07
Frankel, unpublished data), suggests that down-regulating Htr2c receptor expression is not sufficient to account for the handling-induced seizures.
Gene_expression (expression) of Htr2c associated with convulsion
2) Confidence 0.74 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 1.01 Pain Relevance 0.06
Two studies tried to establish a correlation between ADAR mRNA expression level and editing frequency of 5-HT2CR and GluR-B transcripts [45,47], but concluded that changes in expression level only is an insufficient model.
Gene_expression (expression) of 5-HT2CR in ADAR
3) Confidence 0.65 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.09 Pain Relevance 0.07
Interestingly, the expression of ADAR2 mRNA does not correspond temporally or spatially with its physiological substrates, GluR-B and 5-HT2CR.
Gene_expression (expression) of 5-HT2CR
4) Confidence 0.58 Published 2009 Journal Mol Brain Section Body Doc Link PMC2694175 Disease Relevance 0.07 Pain Relevance 0
This suggests that factors in addition to reduced expression of Htr2c contribute to seizure threshold in Brunol4Ff/+ mice.
Gene_expression (expression) of Htr2c associated with convulsion
5) Confidence 0.58 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1934399 Disease Relevance 0.88 Pain Relevance 0.12
Early life stress alters adult serotonin 2C receptor pre-mRNA editing and expression of the alpha subunit of the heterotrimeric G-protein G q.
Gene_expression (expression) of 2C receptor associated with stress and serotonin
6) Confidence 0.23 Published 2007 Journal J. Neurosci. Section Title Doc Link 17287521 Disease Relevance 1.18 Pain Relevance 0.41
The presence of 1 microM serotonin stimulates growth of serotonin-5HT2C receptor- expressing cells by approximately 100% with respect to normal 3T3DA cells.
Gene_expression (expressing) of serotonin-5HT2C receptor associated with serotonin
7) Confidence 0.13 Published 1997 Journal J. Cell. Physiol. Section Abstract Doc Link 9119893 Disease Relevance 0.09 Pain Relevance 0.94
This consideration is particularly relevant in evaluating the 5-HT2C null and DAT KD mice as models for OCD.
Gene_expression (null) of 5-HT2C associated with anxiety disorder
8) Confidence 0.13 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 1.21 Pain Relevance 0.10
The 5-HT2C subtype of the serotonin receptor family is a G-protein coupled receptor (GPCR) that is broadly expressed in the brain and is proposed to mediate many of the central nervous system actions of serotonin, including those underlying the therapeutic benefit of SSRI treatment in OCD [15].
Gene_expression (subtype) of 5-HT2C in central nervous system associated with anxiety disorder, central nervous system, ssri and serotonin
9) Confidence 0.11 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.92 Pain Relevance 0.26
The expressed 5-HT2C receptor exhibits homologous and heterologous desensitization in oocytes [32] mediated by protein kinase C [33-35].
Gene_expression (expressed) of 5-HT2C receptor in oocytes associated with kinase c
10) Confidence 0.01 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC165579 Disease Relevance 0 Pain Relevance 0.20

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