INT69021

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Context Info
Confidence 0.01
First Reported 1997
Last Reported 1998
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 6
Disease Relevance 0.64
Pain Relevance 3.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (Hrh1) plasma membrane (Hrh1) nucleus (Hrh1)
cytoplasm (Hrh1) signal transducer activity (Hrh1)
Anatomy Link Frequency
astrocytes 4
B104 2
Hrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 20 99.40 Very High Very High Very High
Spinal cord 16 99.28 Very High Very High Very High
tetrodotoxin 50 99.12 Very High Very High Very High
Root ganglion neuron 4 98.60 Very High Very High Very High
addiction 2 82.96 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 4 98.28 Very High Very High Very High
Neuroblastoma 6 94.24 High High
Syndrome 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The presence of rH1 mRNA and protein in non-stellate astrocytes in vitro provides a possible correlate for the TTX-resistant current that has been recorded in these cells.
Transcription (presence) of rH1 in astrocytes associated with tetrodotoxin
1) Confidence 0.01 Published 1998 Journal Glia Section Abstract Doc Link 9633805 Disease Relevance 0.06 Pain Relevance 0.64
Since TTX-resistant current is not present in stellate astrocytes, the presence of rH1 mRNA and protein in these cells suggests, in addition, that post-translational mechanisms participate in the control of sodium channel expression in these cells.
Transcription (presence) of rH1 in astrocytes associated with tetrodotoxin and sodium channel
2) Confidence 0.01 Published 1998 Journal Glia Section Abstract Doc Link 9633805 Disease Relevance 0.05 Pain Relevance 0.54
Hybridization signal for rH1 mRNA was detected by in situ hybridization cytochemistry in most non-stellate and, at varying levels, in stellate astrocytes in these cultures.
Transcription (detected) of rH1 in astrocytes
3) Confidence 0.01 Published 1998 Journal Glia Section Abstract Doc Link 9633805 Disease Relevance 0.09 Pain Relevance 0.68
However, RT-PCR demonstrated the presence of rH1 mRNA in cultured spinal cord astrocytes derived from postnatal day 0 (P0) Sprague Dawley rats at 7 days in vitro and in also intact spinal cords of P0 and P7 rats.
Transcription (presence) of rH1 in astrocytes associated with spinal cord
4) Confidence 0.01 Published 1998 Journal Glia Section Abstract Doc Link 9633805 Disease Relevance 0.10 Pain Relevance 0.71
Using RT-PCR and restriction enzyme mapping, we were unable to detect alpha SNS, but detected mRNA for rH1, which is known to encode a TTX-resistant channel, in B104 cells.
Transcription (detected) of rH1 in B104 associated with tetrodotoxin
5) Confidence 0.00 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9120565 Disease Relevance 0.17 Pain Relevance 0.76
We distinguished Tetrodotoxin (TTX)-sensitive and -resistant Na+ currents and detected the mRNA for the cardiac rH1 channel in B104 cells.
Transcription (detected) of rH1 in B104 associated with tetrodotoxin
6) Confidence 0.00 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9120565 Disease Relevance 0.17 Pain Relevance 0.35

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