INT69029

Context Info Confidence 0.75 First Reported 1997 Last Reported 2010 Negated 25 Speculated 1 Reported most in Body Documents 127 Total Number 130 Disease Relevance 74.26 Pain Relevance 11.57

plasma membrane (PTPRC)

Anatomy Link Frequency T cells 7 hematopoietic cells 5 hematopoietic stem cells 4 Memory T cells 3 mesothelial cells 3 PTPRC (Homo sapiens)

Pain Link Frequency Relevance Heat intrathecal 6 99.98 cerebral cortex 5 99.84 Inflammation 1605 99.60 allodynia 10 99.50 Arthritis 242 99.12 bradykinin 24 99.04 Thermal hyperalgesia 13 99.00 endometriosis 168 98.96 chemokine 173 98.80 Spinal cord 83 98.36

Disease Link Frequency Relevance Heat Cold Sores 504 100.00 Ebola Virus Infection 385 100.00 Acquired Immune Deficiency Syndrome Or Hiv Infection 244 100.00 Adhesions 182 100.00 Leukemia 44 100.00 T-cell Leukemia 1 100.00 Follicular Lymphoma 22 99.98 Sprains And Strains 64 99.88 Malignant Neoplastic Disease 209 99.84 Corneal Disease 120 99.84

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In this gate, CECs were identified as positive for the specific marker CD146 (melanoma cell adhesion molecule (MCAM), a cell-adhesion molecule used as a marker for endothelial cell lineage) and negative for the hematopoietic marker CD45 (PTPRC, present on all differentiated hematopoietic cells; Figure 1).

Neg (negative) Gene_expression (negative) of PTPRC in hematopoietic cells associated with skin cancer and adhesions

1) Confidence 0.75 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.29 Pain Relevance 0

The identity of gated cells was further confirmed to be microglial, as opposed to intravascular neutrophils or monocytes, by their lower levels of CD45 expression (Sedgwick et al., 1991) in control and injured rats (data not shown).

Gene_expression (expression) of CD45 in monocytes

2) Confidence 0.75 Published 2007 Journal J Neurosci Methods Section Body Doc Link PMC2726922 Disease Relevance 0.06 Pain Relevance 0.05

In this gate, CECs were identified as positive for the specific marker CD146 (melanoma cell adhesion molecule (MCAM), a cell-adhesion molecule used as a marker for endothelial cell lineage) and negative for the hematopoietic marker CD45 (PTPRC, present on all differentiated hematopoietic cells; Figure 1).

Neg (negative) Gene_expression (negative) of CD45 in hematopoietic cells associated with skin cancer and adhesions

3) Confidence 0.75 Published 2010 Journal Crit Care Section Body Doc Link PMC2911749 Disease Relevance 0.29 Pain Relevance 0

Immunoreactivity with vs38c, CD79a, kappa light chain, and IgG was readily identified in tumor cells; while only focal cells expressed CD20 and LCA (CD45RB).

Gene_expression (expressed) of LCA associated with cancer

4) Confidence 0.75 Published 2002 Journal Oral Oncol. Section Abstract Doc Link 11755827 Disease Relevance 1.68 Pain Relevance 0.07

By gating intact leukocytes on forward scatter (FSC) and side scatter (SSC) properties as well as by their CD16 and CD45 signals (Figure 1), leukocytes were separated into neutrophils (R4 in Figure 1D), eosinophils (R8 in Figure 1C), basophils (R5 in Figure 1B), monocytes (R6 in Figure 1B) and lymphocytes (R7 in Figure 1B) [24,25].

Gene_expression (signals) of CD45 in neutrophils associated with hypersensitivity

5) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.10 Pain Relevance 0

All samples were labeled with CD16-Pcy5 (IM2642, Immunotech, Marseille, France) and CD45-ECD (IM2710, Immunotech) for 15 minutes at RT.

Gene_expression (labeled) of CD45

6) Confidence 0.65 Published 2007 Journal Respir Res Section Body Doc Link PMC1810251 Disease Relevance 0.29 Pain Relevance 0

Blast cells were positive for leukocyte common antigen (CD 45).

Gene_expression (positive) of CD 45 in Blast cells

7) Confidence 0.65 Published 1997 Journal Med. Pediatr. Oncol. Section Abstract Doc Link 9121404 Disease Relevance 0.75 Pain Relevance 0.07

Immunohistochemically the lesion was diffuse strong positive with CD99 and NSE, negative with LCA, pancytokeratin, vimentin, desmin, smooth muscle actin, chromogranine A and S-100.

Neg (negative) Gene_expression (negative) of LCA in smooth muscle

8) Confidence 0.65 Published 2006 Journal Int Urol Nephrol Section Abstract Doc Link 16868682 Disease Relevance 1.03 Pain Relevance 0.09

Consistent with other studies using a similar approach [49], preliminary experiments using the same conditioning regimen and transplanting CD45.1+ bone marrow into irradiated CD45.1?

Gene_expression (transplanting) of CD45 in bone marrow

9) Confidence 0.65 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.36 Pain Relevance 0.03

Consistent with other studies using a similar approach [49], preliminary experiments using the same conditioning regimen and transplanting CD45.1+ bone marrow into irradiated CD45.1?

Gene_expression (bone marrow) of CD45 in bone marrow

10) Confidence 0.65 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504049 Disease Relevance 0.35 Pain Relevance 0.03

T cell receptor and for CD45 contains predominantly ??

Gene_expression (contains) of CD45 in T cell

11) Confidence 0.65 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0 Pain Relevance 0

Tumor cells were negative for cytokeratin, CD45, CD20, CD3, CD30, CD68, CD35 and CD1a; Ki-67 was positive in about 15% of the cells.

Neg (negative) Gene_expression (negative) of CD45 associated with cancer

12) Confidence 0.65 Published 2008 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2556649 Disease Relevance 0.63 Pain Relevance 0

Stratification with respect to the expression of CD45 indicates that specifically the CD45dimCD34+KDR+ cell population correlates with cardiovascular disease and is significantly regulated by statin treatment, suggesting that the CD45dim fraction contains the prognostic relevant EPC populations.

Gene_expression (expression) of CD45 associated with cardiovascular disease

13) Confidence 0.56 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0.51 Pain Relevance 0

The Ki-67 index (MIB-1) was >50%, but other markers such as cytokeratin AE1/AE3, smooth muscle actin, S-100 protein, CD34, and CD45 were negative.

Neg (negative) Gene_expression (negative) of CD45 in smooth muscle

14) Confidence 0.53 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.81 Pain Relevance 0.07

As expected, CD34, CD45 and TERT could not be detected on any examined time point [see Additional file 2].

Neg (not) Gene_expression (detected) of CD45

15) Confidence 0.50 Published 2007 Journal BMC Genomics Section Body Doc Link PMC1829400 Disease Relevance 0.07 Pain Relevance 0

Since recent studies suggest that particularly the fraction of CD45?

Gene_expression (fraction) of CD45

16) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0.18 Pain Relevance 0

This will exclude CD45?

Gene_expression (exclude) of CD45

17) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0.59 Pain Relevance 0

Quantification was performed strictly following the sequential gating strategy [13] and CD34+ cells were additionally subdivided in CD45?

Gene_expression (subdivided) of CD45

18) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0.65 Pain Relevance 0.05

The lower limit of CD45 expression is adapted from a CD34 vs.

Gene_expression (expression) of CD45

19) Confidence 0.48 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2972200 Disease Relevance 0.53 Pain Relevance 0

The Ki-67 index (MIB-1) was >50%, but other markers such as cytokeratin AE1/AE3, smooth muscle actin, S-100 protein, CD34, and CD45 were negative.

Neg (negative) Gene_expression (negative) of CD45 in smooth muscle

20) Confidence 0.46 Published 2008 Journal General thoracic and cardiovascular surgery Section Abstract Doc Link 19085056 Disease Relevance 0.81 Pain Relevance 0.07

General Comments

This test has worked.