INT69030

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Context Info
Confidence 0.31
First Reported 1997
Last Reported 2004
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 7
Disease Relevance 5.57
Pain Relevance 2.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL18, IL12A) extracellular region (IL18, IL12A) cytoplasm (IL18, IL12A)
cytosol (IL18) cell-cell signaling (IL18)
Anatomy Link Frequency
natural killer cells 1
T cells 1
IL18 (Homo sapiens)
IL12A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 495 98.96 Very High Very High Very High
cytokine 93 95.00 High High
Inflammation 27 82.56 Quite High
cINOD 7 25.00 Low Low
methotrexate 20 5.00 Very Low Very Low Very Low
Crohn's disease 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 495 98.96 Very High Very High Very High
Aging 10 83.52 Quite High
INFLAMMATION 34 82.56 Quite High
Disease 32 81.52 Quite High
Autoimmune Disease 5 8.48 Low Low
Adhesions 20 5.00 Very Low Very Low Very Low
Mycobacterial Infection 20 5.00 Very Low Very Low Very Low
Opportunistic Infections 5 5.00 Very Low Very Low Very Low
Frailty 5 5.00 Very Low Very Low Very Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Exogenous IL-18 increased IL-12-induced IFN-?
IL-18 Positive_regulation (increased) of IL-12-induced
1) Confidence 0.31 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.84 Pain Relevance 0.39
IL-18 increased IL-12-stimulated IFN-?
IL-18 Positive_regulation (increased) of IL-12-stimulated
2) Confidence 0.31 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400411 Disease Relevance 1.17 Pain Relevance 0.59
In cells activated with PHA and PMA, IL-18 increased by 71.4% the IL-12-stimulated IFN-?
IL-18 Positive_regulation (increased) of IL-12-stimulated
3) Confidence 0.31 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.21 Pain Relevance 0.54
However, IL-18 increased IL-12-stimulated IFN-?
IL-18 Positive_regulation (increased) of IL-12-stimulated
4) Confidence 0.31 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.22 Pain Relevance 0.54
Exogenous IL-18 slightly augmented the IL-12-induced IFN-?
IL-18 Positive_regulation (augmented) of IL-12-induced
5) Confidence 0.31 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.80 Pain Relevance 0.40
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IGIF Positive_regulation (inducer) of IL-12 in natural killer cells
6) Confidence 0.09 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.16 Pain Relevance 0.13
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IGIF Positive_regulation (inducer) of IL-12 in T cells
7) Confidence 0.03 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.16 Pain Relevance 0.13

General Comments

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