INT69031

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Context Info
Confidence 0.13
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 4.23
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL12A) extracellular region (IL12A) cytoplasm (IL12A)
Anatomy Link Frequency
natural killer cells 2
T cells 2
IL12A (Homo sapiens)
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 396 98.64 Very High Very High Very High
cytokine 88 95.00 High High
Inflammation 24 84.08 Quite High
cINOD 8 25.00 Low Low
methotrexate 16 23.40 Low Low
Opioid 6 5.00 Very Low Very Low Very Low
Crohn's disease 4 5.00 Very Low Very Low Very Low
drug abuse 3 5.00 Very Low Very Low Very Low
opiate 1 5.00 Very Low Very Low Very Low
Morphine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 396 98.64 Very High Very High Very High
Infection 64 95.88 Very High Very High Very High
Hepatitis C Virus Infection 117 95.48 Very High Very High Very High
Opiate Addiction 79 94.68 High High
INFLAMMATION 32 84.08 Quite High
Disease 31 83.04 Quite High
Autoimmune Disease 5 70.16 Quite High
Frailty 4 39.76 Quite Low
Aging 8 18.08 Low Low
Adhesions 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
in PBMC cultures, and IL-12 and IL-18 augment IFN-?
IL-12 Positive_regulation (augment) of IFN
1) Confidence 0.13 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.62 Pain Relevance 0.43
IL-12 can potently and selectively stimulate IFN-?
IL-12 Positive_regulation (stimulate) of IFN
2) Confidence 0.13 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.46 Pain Relevance 0.39
In contrast, IL-12 alone (1 ng/ml) induced a high IFN-?
IL-12 Positive_regulation (induced) of IFN
3) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0 Pain Relevance 0
IL-12 induced significant levels of IFN-?
IL-12 Positive_regulation (induced) of IFN
4) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.34 Pain Relevance 0.17
IL-12 plays a key role in the induction of IFN-?
IL-12 Positive_regulation (induction) of IFN
5) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2834757 Disease Relevance 2.14 Pain Relevance 0
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IL-12 Positive_regulation (inducer) of interferon in natural killer cells
6) Confidence 0.01 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.17 Pain Relevance 0.13
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IL-12 Positive_regulation (inducer) of IFN in natural killer cells
7) Confidence 0.01 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.17 Pain Relevance 0.13
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IL-12 Positive_regulation (inducer) of interferon in T cells
8) Confidence 0.00 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.17 Pain Relevance 0.13
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IL-12 Positive_regulation (inducer) of IFN in T cells
9) Confidence 0.00 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.17 Pain Relevance 0.13

General Comments

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