INT69032

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Context Info
Confidence 0.23
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 7.87
Pain Relevance 3.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
natural killer cells 2
T cells 2
Th1 cells 1
IL18 (Homo sapiens)
IFNA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 693 98.96 Very High Very High Very High
cytokine 226 96.88 Very High Very High Very High
chemokine 23 91.36 High High
Inflammation 135 89.20 High High
cINOD 13 25.00 Low Low
antagonist 34 5.00 Very Low Very Low Very Low
methotrexate 32 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Crohn's disease 8 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 693 98.96 Very High Very High Very High
Asthma 315 93.72 High High
Occupational Lung Diseases 15 92.28 High High
INFLAMMATION 153 89.20 High High
Aging 14 83.84 Quite High
Disease 63 83.04 Quite High
Autoimmune Disease 7 69.76 Quite High
Hypersensitivity 9 67.80 Quite High
Pulmonary Disease 2 49.44 Quite Low
Mycobacterial Infection 29 49.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, later studies showed that exogenous IL-18 in the absence of IL-12 failed to drive the differentiation of naive T cells to Th1 cells [16] and that IL-18 was a potent inducer of IFN-?
IL-18 Positive_regulation (inducer) of IFN in Th1 cells
1) Confidence 0.23 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.36 Pain Relevance 0.28
In cells activated with PHA and PMA, IL-18 increased by 71.4% the IL-12-stimulated IFN-?
IL-18 Positive_regulation (increased) of IFN
2) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.21 Pain Relevance 0.54
IL-18 increased IL-12-stimulated IFN-?
IL-18 Positive_regulation (increased) of IFN
3) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Abstract Doc Link PMC400411 Disease Relevance 1.18 Pain Relevance 0.59
in PBMC cultures, and IL-12 and IL-18 augment IFN-?
IL-18 Positive_regulation (augment) of IFN
4) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.62 Pain Relevance 0.43
Exogenous IL-18 increased IL-12-induced IFN-?
IL-18 Positive_regulation (increased) of IFN
5) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.84 Pain Relevance 0.39
However, IL-18 increased IL-12-stimulated IFN-?
IL-18 Positive_regulation (increased) of IFN
6) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 1.22 Pain Relevance 0.54
Exogenous IL-18 slightly augmented the IL-12-induced IFN-?
IL-18 Positive_regulation (augmented) of IFN
7) Confidence 0.16 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.80 Pain Relevance 0.40
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IGIF Positive_regulation (inducer) of IFN in natural killer cells
8) Confidence 0.15 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.17 Pain Relevance 0.13
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IGIF Positive_regulation (inducer) of interferon in natural killer cells
9) Confidence 0.15 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.17 Pain Relevance 0.13
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IGIF Positive_regulation (inducer) of interferon in T cells
10) Confidence 0.05 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.17 Pain Relevance 0.13
Like IL-12, IGIF is a potent inducer of interferon (IFN)-gamma from T cells and natural killer cells.
IGIF Positive_regulation (inducer) of IFN in T cells
11) Confidence 0.05 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.17 Pain Relevance 0.13
IL-18 is able to induce IFN-?
IL-18 Positive_regulation (induce) of IFN
12) Confidence 0.02 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.98 Pain Relevance 0.13

General Comments

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