INT69033

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Context Info
Confidence 0.58
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 22
Disease Relevance 13.15
Pain Relevance 7.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
CMK 2
macrophages 1
brain 1
central nervous system 1
nerve 1
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 503 100.00 Very High Very High Very High
cytokine 211 100.00 Very High Very High Very High
allodynia 12 99.90 Very High Very High Very High
Antinociceptive 14 99.48 Very High Very High Very High
antagonist 27 99.26 Very High Very High Very High
cINOD 32 98.80 Very High Very High Very High
Arthritis 21 98.80 Very High Very High Very High
anesthesia 5 98.72 Very High Very High Very High
IPN 42 98.56 Very High Very High Very High
Central nervous system 3 95.28 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 552 100.00 Very High Very High Very High
Brain Injury 5 100.00 Very High Very High Very High
Neuropathic Pain 32 99.90 Very High Very High Very High
Arthritis 20 98.80 Very High Very High Very High
Inflammatory Pain 42 98.56 Very High Very High Very High
Disease 61 97.96 Very High Very High Very High
Bacterial Infection 10 97.64 Very High Very High Very High
Nociception 97 97.36 Very High Very High Very High
Nervous System Injury 11 95.92 Very High Very High Very High
Apoptosis 13 95.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, the treatment of mice with a selective inhibitor of caspase-1 had reduced collagen-induced arthritis [11].
Negative_regulation (inhibitor) of caspase-1 associated with arthritis
1) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 1.13 Pain Relevance 0.51
For a clinical perspective, we evaluated the effect of a selective inhibitor of caspase-1 (Ac-YVAD-CMK) on inflammatory hypernociception.
Negative_regulation (inhibitor) of caspase-1 in CMK associated with inflammation
2) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 1.01 Pain Relevance 0.44
Indeed, caspase-1 null mice present a reduction in carrageenin-induced hypernociception, and a selective inhibitor of caspase-1 presents an antinociceptive effect in this mice model.
Negative_regulation (inhibitor) of caspase-1 associated with antinociceptive
3) Confidence 0.58 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.64 Pain Relevance 0.44
Caspase-1 was blocked using the selective inhibitors Ac-YVAD-CMK and VRTXSD727.
Negative_regulation (blocked) of Caspase-1 in CMK
4) Confidence 0.43 Published 2010 Journal Anesthesiology Section Body Doc Link 20823759 Disease Relevance 0.19 Pain Relevance 0
Caspase-1 inhibition also reduced edema and the normally observed increase in paw warmth around the wound site.
Negative_regulation (inhibition) of Caspase-1 in paw
5) Confidence 0.43 Published 2010 Journal Anesthesiology Section Body Doc Link 20823759 Disease Relevance 0.13 Pain Relevance 0
Correspondingly, caspase-1 inhibition significantly reduced interleukin-1?
Negative_regulation (inhibition) of caspase-1
6) Confidence 0.43 Published 2010 Journal Anesthesiology Section Body Doc Link 20823759 Disease Relevance 0.12 Pain Relevance 0
For instance, a selective inhibitor of caspase-1 was found to inhibit yeast-induced hypernociception in rats [12].
Negative_regulation (inhibitor) of caspase-1
7) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 1.17 Pain Relevance 0.58
Our present results corroborate a previous finding of Elford et al. (1995) that showed that the treatment of rats with a selective inhibitor of caspase-1 reduced mechanical hypernociception in a model of yeast-induced inflammation [12].
Negative_regulation (inhibitor) of caspase-1 associated with inflammation
8) Confidence 0.43 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.71 Pain Relevance 0.51
Next, it was evaluated whether the reduction of inflammatory hypernociception in casp1-/- mice was associated with a reduction in the production of pro-nociceptive cytokines (TNF?
Spec (whether) Negative_regulation (reduction) of casp1 associated with nociception, inflammation and cytokine
9) Confidence 0.42 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.78 Pain Relevance 0.34
Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction.
Negative_regulation (reduces) of caspase-1 in brain associated with anesthesia and brain injury
10) Confidence 0.42 Published 2001 Journal Neurosurgery Section Title Doc Link 11383749 Disease Relevance 0.38 Pain Relevance 0.10
(~19 kDa) was reduced in casp1-/- (Figure 4E).
Negative_regulation (reduced) of casp1
11) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.36 Pain Relevance 0.18
HCT1026 treatment was associated to (i) decreased mRNA levels of pro-inflammatory cytokines, caspase-1, and iNOS in blood cells; (ii) decreased ability of encephalitogenic T cells to proliferate; (iii) reduced number of central nervous system (CNS)-infiltrating T cells; (iv) decreased axonal loss and demyelination; (v) increased CD4(+) CD69(-) CD25(+) regulatory T cells in the spleen.
Negative_regulation (decreased) of caspase-1 in central nervous system associated with demyelination, inflammation, central nervous system and cytokine
12) Confidence 0.30 Published 2004 Journal J. Neuroimmunol. Section Abstract Doc Link 15081244 Disease Relevance 0.89 Pain Relevance 0.40
A single subcutaneous injection of ozone performed 12 h after the surgical procedure decreased mechanical allodynia and normalized the mRNA caspase-1, caspase-12 and caspase-8 gene levels, but did not the decrease caspase-3 level, 14 days post-spared nerve injury.
Negative_regulation (normalized) of caspase-1 in nerve associated with nervous system injury and allodynia
13) Confidence 0.23 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19100257 Disease Relevance 1.95 Pain Relevance 0.83
Specific caspase-1 inhibitors would provide a new class of anti-inflammatory drugs with multipotent action.
Negative_regulation (inhibitors) of caspase-1 associated with inflammation and cinod
14) Confidence 0.19 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.23 Pain Relevance 0.24
A selective caspase-1 inhibitor blocks both lipopolysaccharide-induced IL-1beta and IFN-gamma production from human mononuclear cells.
Negative_regulation (inhibitor) of caspase-1 in mononuclear cells
15) Confidence 0.19 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.17 Pain Relevance 0.22
Furthermore, caspase-1-deficient mice are defective in lipopolysaccharide-induced IFN-gamma production.
Negative_regulation (defective) of caspase-1-deficient
16) Confidence 0.19 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.16 Pain Relevance 0.23
Pretreatment with the protein synthesis inhibitor cycloheximide (0. 3-85nmol), the NF-kappaB inhibitor pyrrolidinedithiocarbamate (PDTC) (0.001-1000pmol), the IL-1 receptor antagonist (IL-1ra) protein (0. 01-100ng), the caspase-1 inhibitor (YVAD) (0.1-300pmol), and the anti-inflammatory cytokine IL-10 (0.1-300ng) all dose-dependently reduced the induction of dynorphin-induced allodynia.
Negative_regulation (inhibitor) of caspase-1 associated with allodynia, dynorphin, inflammation, antagonist and cytokine
17) Confidence 0.15 Published 2000 Journal Pain Section Abstract Doc Link 10666520 Disease Relevance 1.02 Pain Relevance 1.54
Inhibition of caspase-1 activity using a specific competitor (Y-VAD-FMK) [12] or a broad caspase inhibitor (Z-VAD-CHO) also blocked Hz-induced IL-1?
Negative_regulation (Inhibition) of caspase-1
18) Confidence 0.13 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2722371 Disease Relevance 0.05 Pain Relevance 0.08
In addition, HCT1026 fed mice exhibited significantly reduced mRNA levels of pro-inflammatory cytokines, caspase-1, and iNOS in blood cells, with reduced number of CNS-infiltrating T cells [66].
Negative_regulation (reduced) of caspase-1 in T cells associated with inflammation and cytokine
19) Confidence 0.09 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC3000390 Disease Relevance 0.97 Pain Relevance 0.18
Small molecule approaches include inhibitors of caspase-1, antagonism of P2X7 receptors and generation of inhibitors to components of the IL-18 receptor signalling pathway.
Negative_regulation (inhibitors) of caspase-1
20) Confidence 0.09 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064903 Disease Relevance 0.06 Pain Relevance 0.19

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