INT69034

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Context Info
Confidence 0.27
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 3.56
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
spinal cord 1
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 94 99.64 Very High Very High Very High
Multiple sclerosis 7 96.72 Very High Very High Very High
cytokine 47 96.44 Very High Very High Very High
Spinal cord 8 96.00 Very High Very High Very High
reflex sympathetic dystrophy 3 88.72 High High
cINOD 7 83.76 Quite High
Inflammatory response 8 81.80 Quite High
antagonist 4 73.68 Quite High
Antinociceptive 2 71.80 Quite High
Central nervous system 24 68.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 108 99.64 Very High Very High Very High
Multiple Sclerosis 16 99.42 Very High Very High Very High
Demyelinating Disease 2 95.84 Very High Very High Very High
Apoptosis 2 95.28 Very High Very High Very High
Disease 35 94.04 High High
Bone Fracture 3 90.16 High High
Complex Regional Pain Syndromes 3 88.72 High High
Crystal Associated Disease 71 88.44 High High
Immunization 1 83.96 Quite High
Targeted Disruption 2 74.68 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The participation of caspase-1 in this inflammatory symptom was not associated with the production of pro-inflammatory cytokines (TNF?
Regulation (participation) of caspase-1 associated with inflammation and cytokine
1) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 1.02 Pain Relevance 0.65
Our results thus implicate caspase-1 in the physiological production of IGIF and demonstrate that it plays a critical role in the regulation of multiple proinflammatory cytokines.
Spec (implicate) Regulation (implicate) of caspase-1 associated with cytokine
2) Confidence 0.12 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.15 Pain Relevance 0.23
The activity of caspase-1 is itself tightly regulated and requires the formation of homodimeric complexes of pro-caspase-1 in the presence of the cytoplasmic protein ASC (apoptosis-associated speck-like protein containing a caspase-associated recruitment domain [CARD]) and a protein of the NLR (Nod/NACHT-LRR domains) family.
Regulation (regulated) of caspase-1 associated with apoptosis
3) Confidence 0.10 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592794 Disease Relevance 0.61 Pain Relevance 0.07
The pathological role of IL-18 in EAE is also supported by the up-regulation of caspase-1 (required to convert IL-18 precursor protein into its biologically active mature form) mRNA in the spinal cord of rats with EAE [89], and decreased disease severity in caspase-1 KO mice [100].
Regulation (regulation) of caspase-1 in spinal cord associated with multiple sclerosis, disease and spinal cord
4) Confidence 0.05 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2830964 Disease Relevance 1.79 Pain Relevance 0.41

General Comments

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