INT69035

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Context Info
Confidence 0.69
First Reported 1997
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 43
Total Number 43
Disease Relevance 25.18
Pain Relevance 10.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Casp1) cell death (Casp1) extracellular region (Casp1)
nucleus (Casp1) intracellular (Casp1) protein complex (Casp1)
Anatomy Link Frequency
cleavage 5
spinal cord 4
macrophages 2
THP-1 2
tibia 1
Casp1 (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 25 99.88 Very High Very High Very High
Inflammation 1251 99.84 Very High Very High Very High
Spinal cord 86 99.68 Very High Very High Very High
Inflammatory stimuli 23 99.62 Very High Very High Very High
substance P 9 99.52 Very High Very High Very High
Nerve growth factor 64 99.46 Very High Very High Very High
reflex sympathetic dystrophy 30 99.28 Very High Very High Very High
anesthesia 9 99.16 Very High Very High Very High
cytokine 636 98.98 Very High Very High Very High
Trk A 11 98.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 390 100.00 Very High Very High Very High
Endotoxemia 13 99.98 Very High Very High Very High
Disease 463 99.96 Very High Very High Very High
Multiple Sclerosis 28 99.88 Very High Very High Very High
INFLAMMATION 1430 99.84 Very High Very High Very High
Brain Injury 27 99.80 Very High Very High Very High
Frailty 30 99.12 Very High Very High Very High
Complex Regional Pain Syndromes 30 98.96 Very High Very High Very High
Nociception 142 98.88 Very High Very High Very High
Toxicity 3 98.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, it is also seems that the caspase-1 pro-nociceptive role is not related to neutrophils, because neutrophil accumulation in the mice paws of casp1-/- is similar to WT mice.
Positive_regulation (accumulation) of casp1 in neutrophils associated with nociception
1) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.78 Pain Relevance 0.35
Collectively, these data suggest that NALP3 is the inflammasome that triggers caspase-1 activation in the mediation of carrageenin-induced inflammatory hypernociception, yet other inflammasomes could be also involved.
Positive_regulation (activation) of caspase-1 associated with inflammation
2) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.72 Pain Relevance 0.41
For instance, the NALP1 inflammasome is required for caspase-1 activation and mediates the complex regional pain syndrome that developed after tibia fracture in rats [18].
Positive_regulation (activation) of caspase-1 in tibia associated with complex regional pain syndromes, bone fracture and reflex sympathetic dystrophy
3) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.88 Pain Relevance 0.51
In fact, activation of caspase-1 in the spinal cord has been associated with an increase of central IL-1?
Positive_regulation (activation) of caspase-1 in spinal cord associated with spinal cord
4) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.54 Pain Relevance 0.28
Regarding the mechanisms that trigger caspase-1 activation in the inflammatory process, there is now a large body of recent evidence showing that they are dependent on the assembly of cytosolic multiprotein complexes known as inflammasomes [26,27].
Positive_regulation (activation) of caspase-1 in body associated with inflammation
5) Confidence 0.69 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.64 Pain Relevance 0.40
RESULTS: Immunohistochemical analysis revealed that activated caspase-1 and caspase-3 are present in neurons 24 hours after TBI.
Positive_regulation (activated) of caspase-1 in neurons
6) Confidence 0.68 Published 2001 Journal Neurosurgery Section Body Doc Link 11383749 Disease Relevance 0.17 Pain Relevance 0
Caspase-1 activity, quantified by measuring mature interleukin-1beta production by enzyme-linked immunosorbent assay, was considerably increased in mice that underwent TBI, and this increase was significantly diminished in minocycline-treated mice.
Positive_regulation (increased) of Caspase-1
7) Confidence 0.68 Published 2001 Journal Neurosurgery Section Body Doc Link 11383749 Disease Relevance 0.13 Pain Relevance 0
Our results demonstrate for the first time that both caspase-1 and caspase-3 are activated in neurons following spinal cord injury, and that caspase inhibition reduces post-traumatic lesion size and improves motor performance.
Positive_regulation (activated) of caspase-1 in spinal cord associated with spinal cord
8) Confidence 0.57 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938439 Disease Relevance 0.78 Pain Relevance 0.41
Caspase-1 and caspase-3 activation were also detected by western blot following spinal cord injury, which was significantly inhibited by the broad caspase inhibitor N-benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone.
Positive_regulation (activation) of Caspase-1 in spinal cord associated with spinal cord
9) Confidence 0.57 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938439 Disease Relevance 0.98 Pain Relevance 0.43
and CXCL1/KC) are involved in caspase-1 mediation of inflammatory hypernociception
Positive_regulation (mediation) of caspase-1 associated with inflammation
10) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.84 Pain Relevance 0.36
increased at the same levels in casp1-/- and WT mice after carrageenin injection, there was a reduction in the mature form of IL-1?
Positive_regulation (increased) of casp1
11) Confidence 0.50 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.57 Pain Relevance 0.28
RESULTS: Analysis of enzyme activity demonstrated that caspase-1 activity was significantly increased in periincisional skin.
Positive_regulation (increased) of caspase-1 in skin
12) Confidence 0.46 Published 2010 Journal Anesthesiology Section Body Doc Link 20823759 Disease Relevance 0.16 Pain Relevance 0
These molecules self-oligomerise after stimuli recognition and form high-molecular weight complexes that trigger caspase-1 autoactivation.
Positive_regulation (trigger) of caspase-1
13) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.56 Pain Relevance 0.37
One question that emerges from these results is how caspase-1 is activated during carrageenin-induced paw inflammation.
Positive_regulation (activated) of caspase-1 in paw associated with inflammation
14) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.71 Pain Relevance 0.44
This suggestion is based on the following indirect evidence: a) NALP3-containing inflammasomes that activate caspase-1 generally depend on stimulation of P2X7 [28]; b) P2X7 mediates carrageenin-induced inflammatory hypernociception [29,30]; and c) P2X7 mediation of inflammatory hypernociception depends on stimulation of IL-1?
Positive_regulation (activate) of caspase-1 associated with inflammation
15) Confidence 0.46 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959021 Disease Relevance 0.60 Pain Relevance 0.37
Minocycline reduces traumatic brain injury-mediated caspase-1 activation, tissue damage, and neurological dysfunction.
Positive_regulation (activation) of caspase-1 in brain associated with anesthesia and brain injury
16) Confidence 0.45 Published 2001 Journal Neurosurgery Section Title Doc Link 11383749 Disease Relevance 0.38 Pain Relevance 0.10
However, procaspase-1 was clearly detectable at the protein level in HCE-T cells, while no sign of its activation was observed, as also seen in unstimulated THP-1 cells (Figure 2C).
Positive_regulation (activation) of caspase-1 in THP-1
17) Confidence 0.45 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2526096 Disease Relevance 0 Pain Relevance 0
We demonstrate a 17-fold increase in caspase-1 activity in traumatized spinal cord samples when compared with samples from sham-operated mice.
Positive_regulation (increase) of caspase-1 in spinal cord associated with spinal cord
18) Confidence 0.41 Published 2000 Journal Neuroscience Section Abstract Doc Link 10938439 Disease Relevance 0.99 Pain Relevance 0.43
The cellular production of IL-1beta, a cytokine implicated in a variety of inflammatory diseases, requires cleavage of its precursor (proIL-1beta) at an Asp-X site by interleukin-1beta-converting enzyme (ICE, recently termed caspase-1).
Positive_regulation (requires) of ICE in cleavage associated with inflammation, disease and cytokine
19) Confidence 0.22 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.20 Pain Relevance 0.14
To date the proteins that facilitate efficient coupling of caspase-1 activation to P2X7 stimulation are unclear but their identification may provide interesting alternative therapeutic targets for inflammatory diseases.
Positive_regulation (activation) of caspase-1 associated with inflammation and disease
20) Confidence 0.18 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096758 Disease Relevance 0.37 Pain Relevance 0.15

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