INT69036

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2011
Negated 4
Speculated 4
Reported most in Body
Documents 99
Total Number 134
Disease Relevance 77.92
Pain Relevance 25.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
macrophages 5
plasma 4
endometrium 4
endothelial cells 4
plaque 3
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 2418 100.00 Very High Very High Very High
Inflammation 1896 100.00 Very High Very High Very High
antagonist 198 100.00 Very High Very High Very High
Osteoarthritis 336 99.84 Very High Very High Very High
rheumatoid arthritis 1686 99.80 Very High Very High Very High
Inflammatory marker 18 99.78 Very High Very High Very High
Dismenorea 18 99.72 Very High Very High Very High
Arthritis 312 99.46 Very High Very High Very High
methotrexate 79 99.38 Very High Very High Very High
spinal inflammation 12 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 2098 100.00 Very High Very High Very High
Sepsis 625 100.00 Very High Very High Very High
Cancer 301 100.00 Very High Very High Very High
Myocardial Infarction 236 100.00 Very High Very High Very High
Necrosis 221 100.00 Very High Very High Very High
Adhesions 208 100.00 Very High Very High Very High
Obesity 206 100.00 Very High Very High Very High
Overweight 162 100.00 Very High Very High Very High
Injury 101 100.00 Very High Very High Very High
Dengue 89 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To investigate further into genetic variants within the IL18 promoter region, we observed in the database [51] a variant in this region that could have a potential role in IL-18 expression (IL18-1297 or rs360719).
Gene_expression (expression) of IL-18
1) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.50 Pain Relevance 0.13
Interestingly, Nabili et al. [56] reported and increased expression of IL18 in temporal artery biopsies of GCA patients, with no correlation with clinical manifestations or hematologic parameters.
Gene_expression (expression) of IL18 in temporal artery associated with increased venous pressure under development
2) Confidence 0.77 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.97 Pain Relevance 0.17
Furthermore, we investigated the inhibitory effects of hr IL-10 on IL-18 production by hr CRP in human endothelial cells.
Gene_expression (production) of IL-18 in endothelial cells
3) Confidence 0.77 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.86 Pain Relevance 0.23
C-reactive protein-induced production of interleukin-18 in human endothelial cells: a mechanism of orchestrating cytokine cascade in acute coronary syndrome.
Gene_expression (production) of interleukin-18 in endothelial cells associated with acute coronary syndrome and cytokine
4) Confidence 0.77 Published 2003 Journal Heart Vessels Section Title Doc Link 14520485 Disease Relevance 0.71 Pain Relevance 0.19
To determine the mechanism of accelerating IL-18 production, we examined the release of IL-18 in human endothelial cells using human recombinant (hr) C-reactive protein (CRP) as a stimulator of IL-18.
Gene_expression (production) of IL-18 in endothelial cells
5) Confidence 0.77 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.73 Pain Relevance 0.20
However, the mechanisms of IL-18 in orchestrating the cytokine cascade and the accelerator of IL-18 production in atherosclerosis are still unknown.
Gene_expression (production) of IL-18 associated with increased venous pressure under development and cytokine
6) Confidence 0.77 Published 2003 Journal Heart Vessels Section Abstract Doc Link 14520485 Disease Relevance 0.60 Pain Relevance 0.13
RESULT(S): IL-18 system mRNA and protein expression was demonstrated in the eutopic endometrium of both adenomyosis and control women.
Gene_expression (expression) of IL-18 in endometrium
7) Confidence 0.74 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0.07 Pain Relevance 0
CONCLUSION(S): The expression of the eutopic endometrial IL-18 system and the ratio of antagonist to agonist at the level of the endometrial-myometrial interface (EMI) may possibly be responsible for the pathologic process of adenomyosis.


Gene_expression (expression) of IL-18
8) Confidence 0.74 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0 Pain Relevance 0
We compared the expression of TWEAK and IL-18 under different stimulation to determine if TWEAK regulate IL-18 expression or be regulated by this cytokine.
Gene_expression (expression) of IL-18 associated with cytokine
9) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.08
Our immunohistochemistry and PCR results show that TWEAK doesn't act on IL-18 expression, but seems to control IL-18 related cytotoxicity on uNK cells when IL-18 is over-expressed.
Gene_expression (expression) of IL-18
10) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.12
We compared the expression of TWEAK and IL-18 under different stimulation to determine if TWEAK regulate IL-18 expression or be regulated by this cytokine.
Gene_expression (expression) of IL-18 associated with cytokine
11) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.08
We compared the presence of the uNK cytotoxic receptor, NKp46, in patients with an IL-18 over-expression (if compared to the one observed in fertile patients) and either a low or high mRNA TWEAK expression.
Gene_expression (expression) of IL-18
12) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.21
We also observed that IL-15 and IL-18 expressions were correlated with the local uNK (CD56+) recruitment and subendometrial angiogenesis as reflected by the vascular flow index quantified by 3-D ultrasound with angiography [6].
Gene_expression (expressions) of IL-18
13) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.43 Pain Relevance 0.15
Briefly, TWEAK and IL-18 expression were normalised using geometric mean of three validated references genes (for the endometrium).
Gene_expression (expression) of IL-18 in endometrium
14) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.05
With this model we show that IL-18 and TWEAK expression in endometrium are independent one from the other but share the same way of regulation, the Map Kinase pathway.
Gene_expression (expression) of IL-18 in endometrium
15) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.05 Pain Relevance 0.07
Wilcoxon test was used to compare production of cytokines and growth factors (in different conditions of hormones concentration) and TWEAK, IL-18, NKp46 and TGF-?
Gene_expression (production) of IL-18 associated with cytokine
16) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.05
Therefore we investigated whether TWEAK regulates IL-18 expression or at the opposite if IL-18 acts on TWEAK expression.
Gene_expression (expression) of IL-18
17) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.56 Pain Relevance 0.10
In previous studies, we reported that IL-15 and IL-18 expressions were significantly different in patients who failed to implant when compared with fertile control individuals [5].
Gene_expression (expressions) of IL-18
18) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.28 Pain Relevance 0.16
SEM) of these ratio in our fertile patient group allowing us to obtain the normal range both for IL-18 (3.8 to 6) and TWEAK (4.2–6.5) mRNa expressions.
Gene_expression (expressions) of IL-18
19) Confidence 0.70 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0
To investigate further into genetic variants within the IL18 promoter region, we observed in the database [51] a variant in this region that could have a potential role in IL-18 expression (IL18-1297 or rs360719).
Gene_expression (expression) of IL18
20) Confidence 0.67 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888200 Disease Relevance 0.50 Pain Relevance 0.13

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