INT69037

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Context Info
Confidence 0.43
First Reported 1997
Last Reported 2011
Negated 4
Speculated 1
Reported most in Body
Documents 4
Total Number 8
Disease Relevance 3.29
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (IL18) extracellular space (IL18) extracellular region (IL18)
cell-cell signaling (IL18) cytoplasm (IL18)
Anatomy Link Frequency
endometrium 6
Neurons 2
IL18 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 262 97.76 Very High Very High Very High
Inflammation 105 97.36 Very High Very High Very High
cINOD 5 86.96 High High
Sciatic nerve 4 70.52 Quite High
Spinal cord 6 69.16 Quite High
Central nervous system 20 53.72 Quite High
Dismenorea 2 50.00 Quite Low
metalloproteinase 8 22.64 Low Low
chemokine 16 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 166 98.24 Very High Very High Very High
INFLAMMATION 118 97.36 Very High Very High Very High
Neuroblastoma 22 90.96 High High
Neurodegenerative Disease 16 83.68 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 83.60 Quite High
Toxicity 14 82.32 Quite High
Death 92 81.28 Quite High
Apoptosis 48 78.40 Quite High
Disease 25 73.80 Quite High
Drug Induced Neurotoxicity 4 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULT(S): IL-18 system mRNA and protein expression was demonstrated in the eutopic endometrium of both adenomyosis and control women.
Regulation (RESULT) of Gene_expression (expression) of IL-18 in endometrium
1) Confidence 0.43 Published 2010 Journal Fertil. Steril. Section Body Doc Link 19394601 Disease Relevance 0.07 Pain Relevance 0
With this model we show that IL-18 and TWEAK expression in endometrium are independent one from the other but share the same way of regulation, the Map Kinase pathway.
Neg (independent) Regulation (independent) of Gene_expression (expression) of IL-18 in endometrium
2) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.05 Pain Relevance 0.07
These results highlighted TWEAK and IL-18 expression are independent one from the other in human endometrium but are both regulated via a Map Kinase pathway.


Regulation (regulated) of Gene_expression (expression) of IL-18 in endometrium
3) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0.06 Pain Relevance 0.07
Likewise, there was no variation of IL-18 expression after 24 h of stimulation with recombinant TWEAK or its antibody in the culture supernatant.
Neg (no) Regulation (variation) of Gene_expression (expression) of IL-18
4) Confidence 0.41 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.04
We compared the expression of TWEAK and IL-18 under different stimulation to determine if TWEAK regulate IL-18 expression or be regulated by this cytokine.
Regulation (under) of Gene_expression (expression) of IL-18 associated with cytokine
5) Confidence 0.24 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3017546 Disease Relevance 0 Pain Relevance 0.08
Our results thus implicate caspase-1 in the physiological production of IGIF and demonstrate that it plays a critical role in the regulation of multiple proinflammatory cytokines.
Spec (implicate) Regulation (implicate) of Gene_expression (production) of IGIF associated with cytokine
6) Confidence 0.23 Published 1997 Journal Nature Section Abstract Doc Link 9121587 Disease Relevance 0.15 Pain Relevance 0.24
While IL-18 expression did not change at any time point (data not shown), a robust up-regulation was detected in the expressions of IL-1?
Neg (not) Regulation (change) of Gene_expression (expression) of IL-18
7) Confidence 0.22 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2984415 Disease Relevance 1.92 Pain Relevance 0.38
Neurons have not been implicated as a source of IL-18 in various brain insults, therefore, no change in the expression of IL-18 (data not shown) is not surprising.
Neg (no) Regulation (change) of Gene_expression (expression) of IL-18 in Neurons
8) Confidence 0.10 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2984415 Disease Relevance 1.04 Pain Relevance 0.43

General Comments

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