INT6904

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Context Info
Confidence 0.42
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 1.37
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Cd2) protein complex (Cd2)
Anatomy Link Frequency
lymphocyte 2
external 1
Cd2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 6 99.80 Very High Very High Very High
addiction 2 99.12 Very High Very High Very High
tetrodotoxin 5 98.56 Very High Very High Very High
lidocaine 1 98.24 Very High Very High Very High
Clonidine 8 84.88 Quite High
qutenza 72 83.96 Quite High
abdominal pain 1 70.24 Quite High
agonist 1 44.16 Quite Low
ASIC 18 5.00 Very Low Very Low Very Low
Calcitonin gene-related peptide 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 6 99.80 Very High Very High Very High
Disease 1 96.84 Very High Very High Very High
Hypersensitivity 1 96.24 Very High Very High Very High
Acidosis 141 78.40 Quite High
Vomiting 2 71.68 Quite High
Abdominal Pain 1 70.24 Quite High
Diarrhoea 1 68.64 Quite High
Nephrotoxicity 1 63.44 Quite High
Hepatotoxicity 1 62.16 Quite High
Hypoxia 62 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include: (1) a transient and (2) a steady-state voltage-activated inward current; both are tetrodotoxin (TTX) and saxitoxin (STX) insensitive, partly reduced by decreasing external Ca2+ or Na+ or by addition of 5 mM Co2+, D-600 or verapamil and are totally blocked with 5 mM Cd2+; (3) an early, transient, cation-dependent, outward K+ current (IKCa/Na); (4) a transient, voltage-activated, outward K+ current provisionally identified as IA; (5) a delayed, steady-state, voltage-activated outward K+ current (IK) and (6) a late, transient, outward K+ current which is blocked by Cd2+ and evident only during long voltage pulses.
Negative_regulation (blocked) of Cd2 in external associated with tetrodotoxin
1) Confidence 0.42 Published 1988 Journal Proc. R. Soc. Lond., B, Biol. Sci. Section Abstract Doc Link 2454477 Disease Relevance 0 Pain Relevance 0.09
The RHI Na currents were sensitive to Cd2+ block, and they showed use dependence of TTX and lidocaine block similar to native currents.
Negative_regulation (block) of Cd2 associated with tetrodotoxin, addiction and lidocaine
2) Confidence 0.27 Published 1992 Journal J. Membr. Biol. Section Abstract Doc Link 1335083 Disease Relevance 0 Pain Relevance 0.50
Significant decreases in lymphocyte subsets CD2, CD3, and CD4 were found in both groups; CD56 was significantly decreased only in the placebo group.
Negative_regulation (decreases) of CD2 in lymphocyte
3) Confidence 0.14 Published 1998 Journal Anesth. Analg. Section Abstract Doc Link 9842842 Disease Relevance 0 Pain Relevance 0.44
Gadolinium (0.5 mM) blocks both voltage-gated Ca2+ channels and TRPV1, and Cd2+ blocks voltage-gated Ca2+ entry but actually permeates TRPV1 sufficiently well to induce a major increase in Fura-2 fluorescence.
Negative_regulation (blocks) of Cd2
4) Confidence 0.14 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2765625 Disease Relevance 0.27 Pain Relevance 0.29
Treatment with mycophenolate mofetil reduces rheumatoid factor titres, immunoglobulin (IgG, IgM, and IgA) levels, and the total number of T cells (CD2) in RA patient peripheral blood; in addition, lymphocyte mitogen responses are inhibited and delayed hypersensitivity skin test reactivity is decreased.
Negative_regulation (reduces) of CD2 in lymphocyte associated with hypersensitivity and rheumatoid arthritis
5) Confidence 0.11 Published 1993 Journal Clin. Exp. Rheumatol. Section Abstract Doc Link 8324935 Disease Relevance 1.10 Pain Relevance 0.32

General Comments

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