INT6906

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Context Info
Confidence 0.43
First Reported 1988
Last Reported 2010
Negated 1
Speculated 2
Reported most in Body
Documents 64
Total Number 67
Disease Relevance 20.64
Pain Relevance 7.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (SCN5A)
Anatomy Link Frequency
embryo 2
arm 2
plasma 1
ventricle 1
cleavage 1
SCN5A (Homo sapiens)
SCN5A - R878C (2) SCN5A - Y1767K (1)
Pain Link Frequency Relevance Heat
depression 59 100.00 Very High Very High Very High
tetrodotoxin 35 100.00 Very High Very High Very High
lidocaine 30 99.98 Very High Very High Very High
sodium channel 25 99.96 Very High Very High Very High
Substantia nigra 5 99.76 Very High Very High Very High
parabrachial 3 99.68 Very High Very High Very High
endometriosis 56 99.20 Very High Very High Very High
imagery 7 97.20 Very High Very High Very High
Angina 10 96.48 Very High Very High Very High
headache 16 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 80 100.00 Very High Very High Very High
Appetite Loss 18 99.74 Very High Very High Very High
Body Weight 163 99.20 Very High Very High Very High
Endometriosis 15 99.20 Very High Very High Very High
Diabetes Mellitus 2303 98.84 Very High Very High Very High
Renal Insufficiency 10 98.62 Very High Very High Very High
Injury 21 98.40 Very High Very High Very High
Hypoglycemia 1396 98.04 Very High Very High Very High
Stress 117 97.66 Very High Very High Very High
Weight Loss 28 97.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
By polymerase chain reaction-denaturating high performance liquid chromatography-sequencing, we identified a novel deletion in SCN5A, delQKP 1507-1509, in the DIII-DIV linker of the sodium channel.
Negative_regulation (deletion) of SCN5A associated with sodium channel
1) Confidence 0.43 Published 2003 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 14654377 Disease Relevance 0.23 Pain Relevance 0.28
Lidocaine block of LQT-3 mutant human Na+ channels.
Negative_regulation (block) of LQT-3 associated with lidocaine
2) Confidence 0.37 Published 1996 Journal Circ. Res. Section Title Doc Link 8925557 Disease Relevance 0.25 Pain Relevance 0.26
Accordingly, we present our methods for reducing the cost of IVF.
Negative_regulation (reducing) of IVF
3) Confidence 0.36 Published 1997 Journal Wis. Med. J. Section Abstract Doc Link 9020620 Disease Relevance 0 Pain Relevance 0.09
A lack of professional support for handling the grief reactions after IVF failure was described by both men and women.
Negative_regulation (failure) of IVF
4) Confidence 0.35 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.15 Pain Relevance 0
Information and counseling in an early phase of IVF, concerning grief reactions following IVF failure is recommended.
Negative_regulation (failure) of IVF
5) Confidence 0.35 Published 2010 Journal Acta Obstetricia et Gynecologica Scandinavica Section Body Doc Link PMC2993044 Disease Relevance 0.16 Pain Relevance 0
Lidocaine also shifted the steady-state inactivation of hH1 Na current to hyperpolarized potentials in a dose-dependent manner.
Negative_regulation (inactivation) of hH1 associated with lidocaine
6) Confidence 0.35 Published 1992 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 1336062 Disease Relevance 0 Pain Relevance 0.68
mouse models with a targeted heterozygous disruption of Scn5a (Papadatos et al. 2002, Lei et al. 2005).
Negative_regulation (disruption) of Scn5a
7) Confidence 0.35 Published 2008 Journal Acta Physiologica (Oxford, England) Section Body Doc Link PMC2659387 Disease Relevance 0.37 Pain Relevance 0
Thus, key parameters describing the voltage dependences of the resulting iNa were indistinguishable whether WT hNav1.5 were expressed in the presence or absence of R878C-hNav1.5.
Spec (whether) Negative_regulation (absence) of R878C-hNav1.5 (R878C)
8) Confidence 0.31 Published 2008 Journal Acta Physiologica (Oxford, England) Section Body Doc Link PMC2659387 Disease Relevance 0 Pain Relevance 0.03
These findings are also consistent with a normal trafficking of the R878C-hNav1.5 channel.
Negative_regulation (trafficking) of R878C-hNav1.5 (R878C)
9) Confidence 0.30 Published 2008 Journal Acta Physiologica (Oxford, England) Section Body Doc Link PMC2659387 Disease Relevance 0 Pain Relevance 0
A successful way to reduce the number of twin pregnancies after IVF is to transfer only one embryo (single embryo transfer; SET) [20-26].
Negative_regulation (reduce) of IVF in embryo
10) Confidence 0.30 Published 2010 Journal BMC Pediatr Section Body Doc Link PMC2978208 Disease Relevance 0.12 Pain Relevance 0
Long term costs and effects of reducing the number of twin pregnancies in IVF by single embryo transfer: the TwinSing study

Background

Negative_regulation (reducing) of IVF in embryo
11) Confidence 0.30 Published 2010 Journal BMC Pediatr Section Title Doc Link PMC2978208 Disease Relevance 0 Pain Relevance 0
The aetiology of recurrent IVF implantation failure can be broadly attributed to embryonic or uterine factors, but remains unexplained in most cases [4].
Negative_regulation (failure) of IVF in uterine
12) Confidence 0.29 Published 2009 Journal Reprod Health Section Body Doc Link PMC2795733 Disease Relevance 0 Pain Relevance 0
Of course, ordinary procreation and prenatal genetic testing is also an alternative for them, but if they do not want to risk several abortions, it may be preferable for them to seek IVF and PGD.
Negative_regulation (seek) of IVF
13) Confidence 0.29 Published 2008 Journal Journal of Medical Ethics Section Body Doc Link PMC2602744 Disease Relevance 0.20 Pain Relevance 0
Median number of IVF prescribed was one.
Negative_regulation (number) of IVF
14) Confidence 0.20 Published 2009 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2687907 Disease Relevance 0.40 Pain Relevance 0
This is less than the median number of IVF prescribed [3] in a study from Spain (19).
Negative_regulation (number) of IVF
15) Confidence 0.20 Published 2009 Journal McGill Journal of Medicine : MJM Section Body Doc Link PMC2687907 Disease Relevance 0 Pain Relevance 0
In mutations hH1-F1760K and hH1-N1765K, bupivacaine affinity of inactivated channels was reduced by approximately 20- to 40-fold, in mutation hH1-N406K by approximately sevenfold, and in mutations hH1-Y1767K and hH1-Y1767D by approximately twofold to threefold.
Negative_regulation (reduced) of hH1 (N1765K)
16) Confidence 0.17 Published 2000 Journal Anesthesiology Section Body Doc Link 11020758 Disease Relevance 0 Pain Relevance 0
In mutations hH1-F1760K and hH1-N1765K, bupivacaine affinity of inactivated channels was reduced by approximately 20- to 40-fold, in mutation hH1-N406K by approximately sevenfold, and in mutations hH1-Y1767K and hH1-Y1767D by approximately twofold to threefold.
Negative_regulation (reduced) of hH1 (F1760K)
17) Confidence 0.17 Published 2000 Journal Anesthesiology Section Body Doc Link 11020758 Disease Relevance 0 Pain Relevance 0
In mutations hH1-F1760K and hH1-N1765K, bupivacaine affinity of inactivated channels was reduced by approximately 20- to 40-fold, in mutation hH1-N406K by approximately sevenfold, and in mutations hH1-Y1767K and hH1-Y1767D by approximately twofold to threefold.
Negative_regulation (reduced) of hH1 (Y1767K)
18) Confidence 0.17 Published 2000 Journal Anesthesiology Section Body Doc Link 11020758 Disease Relevance 0 Pain Relevance 0
In mutations hH1-F1760K and hH1-N1765K, bupivacaine affinity of inactivated channels was reduced by approximately 20- to 40-fold, in mutation hH1-N406K by approximately sevenfold, and in mutations hH1-Y1767K and hH1-Y1767D by approximately twofold to threefold.
Negative_regulation (reduced) of hH1 (Y1767D)
19) Confidence 0.17 Published 2000 Journal Anesthesiology Section Body Doc Link 11020758 Disease Relevance 0 Pain Relevance 0
Block of human heart hH1 sodium channels by the enantiomers of bupivacaine.
Negative_regulation (Block) of hH1 in heart associated with sodium channel
20) Confidence 0.15 Published 2000 Journal Anesthesiology Section Title Doc Link 11020758 Disease Relevance 0.10 Pain Relevance 0.19

General Comments

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