INT69075

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Context Info
Confidence 0.02
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 2.43
Pain Relevance 2.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Calb1) nucleus (Calb1) intracellular (Calb1)
cytoplasm (Calb1)
Anatomy Link Frequency
brainstem 2
sympathetic 1
lamina 1
DCVs 1
cortex 1
Calb1 (Mus musculus)
Calb1 - D28K (2)
Pain Link Frequency Relevance Heat
medulla 14 99.96 Very High Very High Very High
Thalamus 2 98.28 Very High Very High Very High
substance P 16 97.48 Very High Very High Very High
Neuropeptide 2 96.44 Very High Very High Very High
Neurotransmitter 3 94.64 High High
Dorsal horn 4 93.80 High High
antagonist 11 89.76 High High
Enkephalin 4 88.56 High High
agonist 10 88.32 High High
depression 38 86.92 High High
Disease Link Frequency Relevance Heat
Schizophrenia 7 99.76 Very High Very High Very High
Disease 2 97.28 Very High Very High Very High
Cognitive Disorder 1 93.84 High High
Brain Disease 1 90.60 High High
Stress 2 89.84 High High
Autism 1 87.24 High High
Depression 38 86.92 High High
Stroke 1 84.80 Quite High
Glioma 1 83.80 Quite High
Glaucoma 1 83.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the electron microscopic level using the ABC method, CB immunoreactivity was observed in the following three neuronal elements: 1) the scalloped central terminal with many dense-cored vesicles (DCVs) in the synaptic glomerulus; 2) some vesicle-containing dendrites (VCDs) inside or outside the synaptic glomerulus; and 3) some axon terminals outside the synaptic glomerulus.
Regulation (immunoreactivity) of CB in DCVs
1) Confidence 0.02 Published 2005 Journal Arch. Histol. Cytol. Section Abstract Doc Link 15827379 Disease Relevance 0 Pain Relevance 0.23
At the light microscopic level, CB immunoreactivity was observed most intensely in the lamina II using the avidin-biotinylated peroxidase complex (ABC) and immunofluorescence methods.
Regulation (immunoreactivity) of CB in lamina
2) Confidence 0.02 Published 2005 Journal Arch. Histol. Cytol. Section Abstract Doc Link 15827379 Disease Relevance 0 Pain Relevance 0.22
In the brainstem, immunoreactivity for tyrosine hydroxylase, tryptophan hydroxylase, and calbindin-D28K was severely reduced throughout the brainstem in all the XPA cases.
Regulation (immunoreactivity) of calbindin-D28K (D28K) in brainstem associated with medulla
3) Confidence 0.02 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 15535132 Disease Relevance 0.56 Pain Relevance 0.63
In the brainstem, immunoreactivity for tyrosine hydroxylase, tryptophan hydroxylase, and calbindin-D28K was severely reduced throughout the brainstem in all the XPA cases.
Regulation (immunoreactivity) of calbindin-D28K (D28K) in brainstem associated with medulla
4) Confidence 0.02 Published 2004 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 15535132 Disease Relevance 0.56 Pain Relevance 0.63
Deregulations of the eCB system in the prefrontal cortex (PFC) may also participate to this disease [8].
Regulation (Deregulations) of eCB in cortex associated with disease
5) Confidence 0.01 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1933592 Disease Relevance 1.23 Pain Relevance 0.28
As a whole, this work provides a more detailed understanding of the role of the sympathetic innervation in the control of the CB chemoreceptor function, including the cellular mechanisms of the action of NE.
Regulation (control) of CB chemoreceptor in sympathetic
6) Confidence 0.00 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9124307 Disease Relevance 0.08 Pain Relevance 0.32

General Comments

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