INT69080

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Context Info
Confidence 0.03
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 1.28
Pain Relevance 2.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Sfxn1) mitochondrion (Sfxn1) molecular_function (Sfxn1)
transmembrane transport (Sfxn1)
Anatomy Link Frequency
blood 3
proximal 3
dendrites 1
Medial 1
synapse 1
Sfxn1 (Mus musculus)
Pain Link Frequency Relevance Heat
long-term potentiation 704 100.00 Very High Very High Very High
tetrodotoxin 25 82.08 Quite High
nMDA receptor 72 81.20 Quite High
Pyramidal cell 56 69.88 Quite High
depression 8 67.48 Quite High
Action potential 8 61.72 Quite High
Hippocampus 81 56.80 Quite High
addiction 8 43.84 Quite Low
amygdala 8 5.00 Very Low Very Low Very Low
antagonist 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 136 91.76 High High
Ganglion Cysts 6 89.36 High High
Targeted Disruption 48 87.88 High High
Neurodegenerative Disease 31 81.68 Quite High
Depression 8 67.48 Quite High
Cancer 9 65.88 Quite High
Congenital Anomalies 8 31.92 Quite Low
Cognitive Disorder 27 5.00 Very Low Very Low Very Low
Anaerobic Bacterial Infections 24 5.00 Very Low Very Low Very Low
Dislocations 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Colonic distension caused an initial transient followed by a sustained, slowly adapting increase in fEPSP activity.
Positive_regulation (increase) of fEPSP
1) Confidence 0.03 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9124361 Disease Relevance 0.33 Pain Relevance 0.08
CONCLUSION: Xy/Ke anesthesia markedly elevates blood (18)F-FDG activity and reduces tumor uptake ratios through inhibition of insulin release in mice kept fasting 4 h, whereas pentobarbital induces a similar but less severe response through insulin resistance.
Positive_regulation (elevates) of F-FDG in blood
2) Confidence 0.01 Published 2005 Journal J. Nucl. Med. Section Body Doc Link 16157537 Disease Relevance 0 Pain Relevance 0
In mice kept fasting 20 h, Xy/Ke and pentobarbital increased blood (18)F-FDG activity (5.5 +/- 2.2 and 4.9 +/- 0.9%ID/g vs. 2.4 +/- 0.3%ID/g) and reduced target-to-blood ratios, but these changes were substantially attenuated, compared with those in mice kept fasting 4 h.
Positive_regulation (increased) of F-FDG in blood
3) Confidence 0.01 Published 2005 Journal J. Nucl. Med. Section Body Doc Link 16157537 Disease Relevance 0 Pain Relevance 0
In mice kept fasting 4 h, Xy/Ke induced a marked elevation of (18)F-FDG activity (percentage injected dose [%ID]) in blood (6.8 +/- 0.9%ID/g vs. 1.1 +/- 0.6%ID/g) and kidneys while decreasing myocardial uptake (2.3 +/- 1.3%ID/g vs. 4.7 +/- 1.8%ID/g).
Positive_regulation (elevation) of F-FDG in blood
4) Confidence 0.01 Published 2005 Journal J. Nucl. Med. Section Body Doc Link 16157537 Disease Relevance 0.07 Pain Relevance 0
Either two trains of high frequency tetanic stimulation or three trains of theta-burst stimulation caused a persistent, pathway specific enhancement of fEPSPs that remained significantly elevated for at least 60 min.
Positive_regulation (enhancement) of fEPSPs
5) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Abstract Doc Link PMC1574331 Disease Relevance 0 Pain Relevance 0.29
Two-pathway stimulation experiments (Fig. 5) have confirmed that increase of proximal fEPSPs, as a result of LTP, was specific to the tetanised pathway and did not reflect a generalised heterosynaptic enhancement of post-synaptic excitability.
Positive_regulation (increase) of fEPSPs in proximal associated with long-term potentiation
6) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0 Pain Relevance 0.48
HFS and TBS markedly augmented fEPSPs that stayed elevated for at least an hour (Figs. 6A, 7A).
Positive_regulation (elevated) of fEPSPs
7) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0 Pain Relevance 0.50
Medial fEPSPs increased to a lesser extent, but remained above pre-TBS level (129S5: 136 ± 19 %; t(12) = -6.33; P < 0.001 and C57: 137 ± 10%; t(10) = -11.05; P < 0.0001).
Positive_regulation (increased) of fEPSPs in Medial
8) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.18 Pain Relevance 0.07
Utilising MEAs, we were able to reliably induce large and persistent LTP of fEPSPs in hippocampal slices by established stimulation protocols.
Positive_regulation (induce) of fEPSPs associated with long-term potentiation
9) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.29 Pain Relevance 0.18
However, as illustrated in Fig. 3A, a significant increase of the proximal fEPSP (electrode 4) was not always concomitant with major enhancement of the population spike (electrode 5) which would be capable of affecting apical dendritic regions.
Positive_regulation (increase) of fEPSP in proximal
10) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.14 Pain Relevance 0
Fig. 3A demonstrates that larger enhancement of proximal fEPSP (electrode 4) was recorded in the absence of a strong population spike (electrode 5) able to invade apical dendrites.
Positive_regulation (enhancement) of fEPSP in dendrites
11) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0 Pain Relevance 0.11
Nonetheless, collectively these data indicate that somatic population spikes are unlikely to be principal contributors to increased proximal fEPSPs after LTP induction.
Positive_regulation (increased) of fEPSPs in proximal associated with long-term potentiation
12) Confidence 0.01 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1574331 Disease Relevance 0.07 Pain Relevance 0.48
The four groups presented similar increases in the strength of field EPSPs (fEPSPs) evoked at the hippocampal CA3-CA1 synapse across classical conditioning sessions, with no significant differences between groups.
Positive_regulation (increases) of fEPSPs in synapse
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2886110 Disease Relevance 0.21 Pain Relevance 0

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