INT691

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Context Info
Confidence 0.48
First Reported 1978
Last Reported 2010
Negated 5
Speculated 2
Reported most in Abstract
Documents 67
Total Number 69
Disease Relevance 24.66
Pain Relevance 32.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (SST) extracellular region (SST) cell-cell signaling (SST)
Anatomy Link Frequency
plasma 3
nerve 3
Pfeiffer 2
hepatocytes 2
vein 2
SST (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 1058 100.00 Very High Very High Very High
Dopamine 537 100.00 Very High Very High Very High
imagery 87 100.00 Very High Very High Very High
Opioid 87 100.00 Very High Very High Very High
Neuropeptide 61 100.00 Very High Very High Very High
Enkephalin 34 100.00 Very High Very High Very High
Endogenous opioid 25 100.00 Very High Very High Very High
substance P 18 100.00 Very High Very High Very High
Calcitonin gene-related peptide 10 100.00 Very High Very High Very High
Spinal cord 4 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Schistosomiasis Mansoni 2 100.00 Very High Very High Very High
Hypoglycemia 109 99.92 Very High Very High Very High
Rheumatoid Arthritis 2 99.84 Very High Very High Very High
Malignant Neoplastic Disease 60 99.76 Very High Very High Very High
Muscular Spasm 4 99.64 Very High Very High Very High
Seronegative Spondarthritis 4 99.60 Very High Very High Very High
Cancer 1041 99.54 Very High Very High Very High
Hepatocellular Cancer 4 99.44 Very High Very High Very High
Schistosomiasis 6 99.28 Very High Very High Very High
Natriuresis 3 99.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Somatostatin: peripheral venoconstrictive activity and interaction with monoamines in man.
Somatostatin Binding (interaction) of associated with somatostatin and monoamine
1) Confidence 0.48 Published 1987 Journal Regul. Pept. Section Title Doc Link 2890184 Disease Relevance 0 Pain Relevance 0.64
The activity of somatostatin is mediated via binding to specific cell surface receptors.
somatostatin Binding (binding) of associated with somatostatin
2) Confidence 0.48 Published 2001 Journal Trop. Med. Int. Health Section Abstract Doc Link 11737838 Disease Relevance 0.87 Pain Relevance 0.45
Epidural somatostatin was associated with no side effects.
somatostatin Neg (no) Binding (associated) of associated with somatostatin and epidural
3) Confidence 0.47 Published 1985 Journal Anesth. Analg. Section Abstract Doc Link 2864884 Disease Relevance 0.16 Pain Relevance 0.99
In this respect, the interaction of opioids with somatostatin receptors on hepatocellular carcinoma cells, and the fact that they are widely used for pain control, may provide some additional clues for the discrepancies during treatment with somatostatin analogues.
somatostatin Binding (interaction) of associated with pain, hepatocellular cancer, somatostatin and opioid
4) Confidence 0.46 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17113072 Disease Relevance 0.57 Pain Relevance 1.18
The inhibitory effect of opioids on HepG2 cells is mediated via interaction with somatostatin receptors.
somatostatin Binding (interaction) of associated with somatostatin and opioid
5) Confidence 0.46 Published 2007 Journal Eur. J. Pharmacol. Section Title Doc Link 17113072 Disease Relevance 0.46 Pain Relevance 1.00
We have found that [125I]Tyr11-somatostatin binds with high affinity to T47D cells.
somatostatin Binding (binds) of associated with somatostatin
6) Confidence 0.41 Published 1995 Journal Cancer Res. Section Abstract Doc Link 7585646 Disease Relevance 0.16 Pain Relevance 0.82
Native SST binds all the five receptor subtypes (SSTRs 1-5).
SST Binding (binds) of associated with somatostatin
7) Confidence 0.39 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2845555 Disease Relevance 0.09 Pain Relevance 0.36
In order to establish whether endogenous opioids play a role in the control of arginine vasopressin (AVP) response to insulin-induced hypoglycemia by interacting with somatostatin (SRIH), seven normal men were submitted to an insulin (0.15 U/kg) tolerance test (ITT) in the presence or absence of naloxone (10 mg in an i.v. bolus), SRIH (4.1 micrograms/min x 90 min) or the combination of the two substances.
somatostatin Binding (interacting) of associated with hypoglycemia, narcan, tolerance, somatostatin and endogenous opioid
8) Confidence 0.38 Published 1991 Journal J. Neural Transm. Gen. Sect. Section Abstract Doc Link 1673342 Disease Relevance 0.24 Pain Relevance 0.67
When the dorsal hand vein (DHV) is locally injected with somatostatin (SS) it spasms visibly.
somatostatin Binding (injected) of in vein associated with somatostatin and muscular spasm
9) Confidence 0.37 Published 1984 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6149197 Disease Relevance 0.35 Pain Relevance 0.64
Acute, complete long-lasting tolerance (tachyphylaxis) develops following 2-4 injections of somatostatin.
somatostatin Binding (injections) of associated with somatostatin and tolerance
10) Confidence 0.37 Published 1984 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 6149197 Disease Relevance 0.36 Pain Relevance 0.74
It is suggested that somatostatin could act on specific receptors in the hand vein, but the mechanism of somatostatin venoconstriction and interaction with vasoactive monoamines remains to be defined.
somatostatin Binding (interaction) of in vein associated with somatostatin and monoamine
11) Confidence 0.37 Published 1987 Journal Regul. Pept. Section Abstract Doc Link 2890184 Disease Relevance 0 Pain Relevance 0.66
Since peptidergic sensory innervation of the airways and the joints are particularly dense, we aimed at investigating the alterations of plasma somatostatin-like immunoreactivity (SST-LI) in response to thoracic and orthopedic surgery, as well as sepsis.
somatostatin Binding (alterations) of in plasma associated with somatostatin and sepsis
12) Confidence 0.37 Published 2010 Journal Peptides Section Abstract Doc Link 20307604 Disease Relevance 0.45 Pain Relevance 0.47
Somatostatin and intestinal schistosomiasis: therapeutic and neuropathological implications in host-parasite interactions.
Somatostatin Binding (interactions) of associated with somatostatin and schistosomiasis mansoni
13) Confidence 0.37 Published 2001 Journal Trop. Med. Int. Health Section Title Doc Link 11737838 Disease Relevance 0.79 Pain Relevance 0.35
Several studies demonstrating a tight interaction between somatostatin and insulin indicate that insulin is another important factor in the regulation of basal and postprandial somatostatin release.
somatostatin Binding (interaction) of associated with somatostatin
14) Confidence 0.36 Published 1983 Journal Scand. J. Gastroenterol. Suppl. Section Abstract Doc Link 6138852 Disease Relevance 0.14 Pain Relevance 0.73
[Intra-articular treatment with somatostatin 14 in rheumatoid arthritis].
somatostatin 14 Binding (treatment) of in articular associated with rheumatoid arthritis and somatostatin
15) Confidence 0.36 Published 1994 Journal Clin Ter Section Title Doc Link 7720354 Disease Relevance 0.47 Pain Relevance 0.42
Naloxone induced peripheral blood nonadherent mononuclear cell and neutrophil chemotaxis at nanomolar concentrations and deactivated their migration toward beta-endorphin, angiotensin II, somatostatin, or interleukin-8 but not toward RANTES, vasoactive intestinal peptide, or substance P.
somatostatin Neg (not) Binding (migration) of in mononuclear cell associated with somatostatin, narcan and substance p
16) Confidence 0.36 Published 2004 Journal Biochemistry Section Abstract Doc Link 14705951 Disease Relevance 0 Pain Relevance 0.58
More recently, it has been suggested that a sst ligand may also act peripherally on the GH/IGF-1 axis by binding to somatostatin receptors on peripheral organs, such as hepatocytes in the liver, to inhibit the secretion of IGF-1 [92].
sst Binding (ligand) of in hepatocytes associated with somatostatin
17) Confidence 0.36 Published 2010 Journal BMC Endocr Disord Section Body Doc Link PMC2887860 Disease Relevance 0.56 Pain Relevance 0.33
Moreover, there is evidence that pairs of distinct receptors such as ssst2-sst3 and sst1-sst5 crosstalk by establishing a physical interaction, which results in altered pharmacological or/and functional properties.
sst Binding (interaction) of
18) Confidence 0.36 Published 2008 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 18242821 Disease Relevance 0 Pain Relevance 0.26
Since peptidergic sensory innervation of the airways and the joints are particularly dense, we aimed at investigating the alterations of plasma somatostatin-like immunoreactivity (SST-LI) in response to thoracic and orthopedic surgery, as well as sepsis.
SST Binding (alterations) of in plasma associated with somatostatin and sepsis
19) Confidence 0.36 Published 2010 Journal Peptides Section Abstract Doc Link 20307604 Disease Relevance 0.45 Pain Relevance 0.48
Scintigraphs with 131I-metaiodobenzylguanidine (131I-MIBG) which is accumulated in the argentaffin granules of the cell, as well as with 111In-pentetreotide for the imaging of somatostatin receptors on the cell surface, are positive in a large proportion of carcinoid patients.
somatostatin Binding (imaging) of associated with carcinoid, somatostatin and imagery
20) Confidence 0.36 Published 1996 Journal Eur. J. Cancer Section Abstract Doc Link 8943676 Disease Relevance 1.06 Pain Relevance 0.22

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