INT69134

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Context Info
Confidence 0.26
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.95
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 2
MPEG1 (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 3 96.08 Very High Very High Very High
epidural 1 94.56 High High
Angina 3 93.04 High High
shoulder pain 1 92.84 High High
analgesia 1 90.00 High High
antagonist 1 83.72 Quite High
Pain 4 83.28 Quite High
palliative 1 77.16 Quite High
carpal tunnel syndrome 7 5.00 Very Low Very Low Very Low
intrathecal 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 37 98.20 Very High Very High Very High
Lung Cancer 4 98.04 Very High Very High Very High
Hemorrhage 3 97.20 Very High Very High Very High
Disease Progression 4 96.88 Very High Very High Very High
Toxicity 6 96.84 Very High Very High Very High
Trepenoma Infection 1 95.68 Very High Very High Very High
Thrombocytopenia 1 93.72 High High
Cv General 3 Under Development 3 93.04 High High
Habitual Abortion 1 93.00 High High
Shoulder Pain 1 92.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As reported here, clinical signs usually emerge during childhood in the attenuated phenotype, and prompt diagnosis requires awareness of the multisystemic manifestations and diverse presentation of MPS I.



Positive_regulation (requires) of MPS I
1) Confidence 0.26 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2903709 Disease Relevance 0.72 Pain Relevance 0
Blood analysis was normal (including platelet count) except for the activated partial thromboplastin (PTT) and prothrombin (PT) time, which exceeded the laboratory limits of determination.
Neg (except) Positive_regulation (activated) of partial thromboplastin in Blood
2) Confidence 0.16 Published 1999 Journal G Ital Cardiol Section Abstract Doc Link 10231678 Disease Relevance 0.90 Pain Relevance 0.29
These results suggest that the lentiviral vector may be used for the delivery and expression of the IDUA gene to cells in vivo for treatment of MPS I.
Positive_regulation (treatment) of MPS I
3) Confidence 0.03 Published 2002 Journal Eur. J. Biochem. Section Abstract Doc Link 12047386 Disease Relevance 0.19 Pain Relevance 0.06
For rare disorders such as MPS I, collaborative studies will be important in moving the field forward and achieving optimal outcomes for these patients and their families.



Positive_regulation (important) of MPS I
4) Confidence 0.03 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727896 Disease Relevance 0.16 Pain Relevance 0
These results illustrate the effectiveness of AAV vectors for delivery and expression of human IDUA gene sequences and for potential treatment of MPS I.
Positive_regulation (treatment) of MPS I
5) Confidence 0.02 Published 1999 Journal Hum. Gene Ther. Section Abstract Doc Link 10498248 Disease Relevance 0.27 Pain Relevance 0.05
Coagulation panel prior to bronchoscopy showed an increased partial thromboplastin time (aPTT).
Positive_regulation (increased) of an increased partial thromboplastin time
6) Confidence 0.01 Published 2001 Journal Ann. Hematol. Section Abstract Doc Link 11261325 Disease Relevance 1.07 Pain Relevance 0.09
Two patients achieved complete response (6%), 10 patients (30%) had a partial response (PR), 9 patients (27%) had stabilization of disease (SD) and 12 patients had disease progression (PD).
Positive_regulation (had) of partial response associated with disease and disease progression
7) Confidence 0.01 Published 1999 Journal J Chemother Section Abstract Doc Link 10078785 Disease Relevance 0.77 Pain Relevance 0.08
Clinical symptoms are based on hypercoagulation of blood, while prothrombin time (PT) activity and activated partial thromboplastin time (APTT) are prolonged.
Positive_regulation (prolonged) of activated partial thromboplastin time in blood
8) Confidence 0.01 Published 1998 Journal Masui Section Abstract Doc Link 9513336 Disease Relevance 0.80 Pain Relevance 0.23
Of 57 evaluable patients, eight (14%) had a partial response (PR), eight (14%) a minor response (MR), and 28 (49%) had no change of disease (NC).
Positive_regulation (had) of partial response associated with disease
9) Confidence 0.00 Published 1997 Journal Int. J. Pancreatol. Section Abstract Doc Link 9127172 Disease Relevance 1.07 Pain Relevance 0.16

General Comments

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