INT69142

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Context Info
Confidence 0.50
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 1.52
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Atxn3) nucleus (Atxn3) cytoplasm (Atxn3)
Anatomy Link Frequency
radius 2
brain 1
nucleus 1
Atxn3 (Mus musculus)
Pain Link Frequency Relevance Heat
Tetrahydrobiopterin 10 95.04 Very High Very High Very High
imagery 3 93.24 High High
Central nervous system 4 57.32 Quite High
Dysuria 1 51.28 Quite High
Calcium channel 8 46.88 Quite Low
midbrain 3 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Migraine 1 5.00 Very Low Very Low Very Low
Kinase C 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Machado-joseph Disease 39 100.00 Very High Very High Very High
Neurologic Manifestations 3 99.48 Very High Very High Very High
Disease 103 94.72 High High
Neurological Disease 2 92.92 High High
Targeted Disruption 77 81.04 Quite High
Airway Obstruction 1 80.24 Quite High
Abnormal Reflex 2 77.88 Quite High
Ataxia 36 64.44 Quite High
Death 2 49.20 Quite Low
Toxicity 42 41.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although 2UIM and 3UIM ataxin-3 are both considered “full length” ataxin-3 isoforms, and both have been used in mechanistic studies of SCA3, the impact of this 3?
Positive_regulation (studies) of SCA3 associated with machado-joseph disease
1) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0.65 Pain Relevance 0
Densitometry for aggregate analysis was carried out using ImageJ software, after background subtraction with a rolling ball radius of 50; soluble and insoluble ataxin-3 levels were normalized to endogenous murine ataxin-3 signal to control for equal protein loading.
Positive_regulation (endogenous) of ataxin-3 in radius
2) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0 Pain Relevance 0.05
These data suggest that an early event in the pathogenesis of SCA3/MJD may be an altered conformation of ataxin-3 within the nucleus that exposes the polyglutamine domain.
Positive_regulation (conformation) of ataxin-3 in nucleus associated with machado-joseph disease
3) Confidence 0.45 Published 2005 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2413192 Disease Relevance 0.39 Pain Relevance 0
Densitometry for aggregate analysis was carried out using ImageJ software, after background subtraction with a rolling ball radius of 50; soluble and insoluble ataxin-3 levels were normalized to endogenous murine ataxin-3 signal to control for equal protein loading.
Positive_regulation (endogenous) of ataxin-3 in radius
4) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2965175 Disease Relevance 0 Pain Relevance 0.05
Therefore, S-T may be effective to neurologic deficits through its mechanism of increasing the level of brain biopterins in MJD.
Positive_regulation (increasing) of MJD in brain associated with neurologic manifestations
5) Confidence 0.01 Published 1996 Journal Rinsho Shinkeigaku Section Abstract Doc Link 9128394 Disease Relevance 0.47 Pain Relevance 0.43

General Comments

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