INT69153

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Context Info
Confidence 0.32
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 22
Total Number 22
Disease Relevance 23.59
Pain Relevance 5.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL5) extracellular region (IL5)
Anatomy Link Frequency
T cells 7
lymphocyte 6
eosinophils 4
Th2 cells 4
spleen 2
IL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 844 100.00 Very High Very High Very High
spastic colon 7 98.92 Very High Very High Very High
nud 13 98.72 Very High Very High Very High
agonist 126 98.56 Very High Very High Very High
Angina 6 98.44 Very High Very High Very High
Inflammation 800 96.04 Very High Very High Very High
abdominal pain 7 94.32 High High
dexamethasone 14 90.92 High High
Inflammatory response 51 87.36 High High
chemokine 219 83.48 Quite High
Disease Link Frequency Relevance Heat
Schistosomiasis 3 99.96 Very High Very High Very High
Hypersensitivity 114 99.70 Very High Very High Very High
Autoimmune Disease 32 99.50 Very High Very High Very High
Chronic Disease 1 99.40 Very High Very High Very High
Asthma 2162 99.28 Very High Very High Very High
Gastrointestinal Disease 5 99.04 Very High Very High Very High
Gastritis 20 99.00 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

5 98.92 Very High Very High Very High
Acute Disease 1 98.86 Very High Very High Very High
Dyspepsia 13 98.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Jaffe JS et al. showed enhanced expression of IL-4, IL-5, and interferon gamma in the peripheral T cells of patients with allergic eosinophilic gastroenteritis [39].
Positive_regulation (enhanced) of Gene_expression (expression) of IL-5 in T cells associated with rhinitis, hypersensitivity and gastroenteritis
1) Confidence 0.32 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 1.27 Pain Relevance 0.19
High IL-5 production by human drug-specific T cell clones.
Positive_regulation (High) of Gene_expression (production) of IL-5 in T cell
2) Confidence 0.29 Published 1997 Journal Int. Arch. Allergy Immunol. Section Title Doc Link 9130515 Disease Relevance 0.19 Pain Relevance 0.18
By contrast, BNL1059 and RGS1746 favoured production of IL-4 which is known to promote production of IgE [10] and, at a lesser extent, of IL-5 which specifically controls production and activation and localization of eosinophils, the major cause of tissue damage in atopic disease [11].
Positive_regulation (promote) of Gene_expression (production) of IL-5 in eosinophils associated with disease
3) Confidence 0.28 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.44 Pain Relevance 0.20
This observation correlates with the elevated levels of TLR3, 4, and 7, Th2 cytokines (IL6 and IL10) at protein level and IL4, IL5, IL6, IL10 at gene level.
Positive_regulation (elevated) of Gene_expression (levels) of IL5 associated with cytokine
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.14 Pain Relevance 0.19
The median levels of IL2, IL4, IL5, IL12, and IFN?
Positive_regulation (median) of Gene_expression (levels) of IL5
5) Confidence 0.22 Published 2008 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2430568 Disease Relevance 0.28 Pain Relevance 0.22
Chakir and colleagues also showed that natural pollen exposure is associated with an increase in lymphocyte numbers, eosinophil recruitment, and IL-5 expression in the bronchial mucosa of nonasthmatic persons with allergic rhinitis [29].
Positive_regulation (increase) of Gene_expression (expression) of IL-5 in lymphocyte associated with rhinitis
6) Confidence 0.18 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 1.47 Pain Relevance 0.06
BAL fluid samples isolated from atopic asthmatic patients also reveal significantly increased levels of IL-5 [18].
Positive_regulation (increased) of Gene_expression (levels) of IL-5 associated with asthma
7) Confidence 0.15 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.24 Pain Relevance 0.38
In animals, IL-33 treatment induces the expression of IL-4, IL-5 and IL-13 in the lung [295] and intraperitoneal injection of IL-33 induces spleen eosinophilia [295].
Positive_regulation (induces) of Gene_expression (expression) of IL-5 in spleen associated with eosinophilia
8) Confidence 0.13 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.27 Pain Relevance 0.09
Increased levels of IL-3, IL-4, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and eosinophils were found in endobronchial biopsy specimens from nonatopic asthma patients [24-27].
Positive_regulation (Increased) of Gene_expression (levels) of IL-5 in eosinophils associated with asthma
9) Confidence 0.13 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 2.53 Pain Relevance 0.22
It also increases eosinophils, eotaxin-positive cells, and IL-5 expression in nasal mucosa biopsy specimens [31] and decreases mast cells [32].
Positive_regulation (increases) of Gene_expression (expression) of IL-5 in mast cells
10) Confidence 0.12 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 0.81 Pain Relevance 0.06
The pyrazole derivative, YM-58483 (BTP2; ), potently inhibits Ca2+ release-activated Ca2+ (CRAC) channels and IL-2 production in T cells and IL-4 and IL-5 production in stimulated murine Th2 cells, and IL-5 production in stimulated human whole blood cells.
Positive_regulation (activated) of in T cells Gene_expression (production) of IL-5 in blood cells
11) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.36 Pain Relevance 0.23
However, levels of eotaxin and IL-5 were increased in BAL after Curosurf treatment, whereas IFN-?
Positive_regulation (whereas) of Gene_expression (levels) of IL-5
12) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.27 Pain Relevance 0.22
The pyrazole derivative, YM-58483 (BTP2; ), potently inhibits Ca2+ release-activated Ca2+ (CRAC) channels and IL-2 production in T cells and IL-4 and IL-5 production in stimulated murine Th2 cells, and IL-5 production in stimulated human whole blood cells.
Positive_regulation (activated) of Gene_expression (production) of IL-5 in T cells
13) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.27 Pain Relevance 0.22
However, levels of eotaxin and IL-5 were increased in BAL after Curosurf treatment, whereas IFN-?
Positive_regulation (increased) of Gene_expression (levels) of IL-5
14) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.26 Pain Relevance 0.22
and increased levels of IL-4, IL-5, and IL-10, an effect that is thought to be mediated by decreasing IL-12 production thereby suggesting that ?
Positive_regulation (increased) of Gene_expression (levels) of IL-5
15) Confidence 0.10 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.63 Pain Relevance 0.54
Perhaps this low rate is explained by the chronicity of the disease with eosinophilia being present only early in the course via stimulation of Th2 lymphocytes and production of IL-4 and IL-5 subsequently generating IgG1 and IgE-secreting cells, and eliciting eosinophilia [9,10].
Positive_regulation (generating) of Gene_expression (production) of IL-5 in lymphocytes associated with disease and eosinophilia
16) Confidence 0.06 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1156894 Disease Relevance 1.60 Pain Relevance 0
In contrast to Th1-mediated autoimmune disorders, allergic disorders are mediated by Th2 cells through the production of IL-4, IL-5, and IL-13.
Positive_regulation (mediated) of Gene_expression (production) of IL-5 in Th2 cells associated with autoimmune disease and hypersensitivity
17) Confidence 0.06 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 1.61 Pain Relevance 0.35
Whereas the expression of IL-4 and IL-5 induced by stimulation of in vitro-differentiated murine Th2 cells with concanavalin A remained unaffected by the chemical inhibitor of p38 SB203580 or a dominant-negative mutant of p38, the induction of IL-4 by phorbol 12-myristate 13-acetate and ionomycin or of IL-5 and IL-13 by phorbol 12-myristate 13-acetate and dibutyryl cAMP was partly abrogated by SB203580 [59,66].
Positive_regulation (induced) of Gene_expression (expression) of IL-5 in Th2 cells
18) Confidence 0.05 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526596 Disease Relevance 0 Pain Relevance 0.03
Higher interferon-gamma levels were detected in PBMC of patients with acute disease than in those of patients with chronic schistosomiasis; IL-5 levels were higher in those with chronic disease.
Positive_regulation (higher) of Gene_expression (levels) of IL-5 in PBMC associated with acute disease, chronic disease and schistosomiasis
19) Confidence 0.05 Published 2002 Journal J. Infect. Dis. Section Abstract Doc Link 11756987 Disease Relevance 1.15 Pain Relevance 0.21
Mainly IL-5, IL-6 and IL-10 levels were increased and those of IFN-?
Positive_regulation (increased) of Gene_expression (levels) of IL-5
20) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 1.09 Pain Relevance 0.46

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