INT69155

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 10.18
Pain Relevance 3.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
nasal 6
eosinophils 4
T cells 2
B cells 1
mast cells 1
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 442 100.00 Very High Very High Very High
lidocaine 2 99.66 Very High Very High Very High
rheumatoid arthritis 56 99.20 Very High Very High Very High
agonist 66 96.96 Very High Very High Very High
Inflammation 421 96.28 Very High Very High Very High
endometriosis 168 93.08 High High
Inflammatory response 32 76.80 Quite High
Central nervous system 23 76.60 Quite High
antagonist 105 73.00 Quite High
aspirin 3 68.96 Quite High
Disease Link Frequency Relevance Heat
Rhinitis 33 99.64 Very High Very High Very High
Multiple Myeloma 1 99.48 Very High Very High Very High
Rheumatoid Arthritis 56 99.20 Very High Very High Very High
Cancer 160 98.32 Very High Very High Very High
Infection 45 96.32 Very High Very High Very High
INFLAMMATION 461 96.28 Very High Very High Very High
Ovarian Cancer 25 96.00 Very High Very High Very High
Asthma 952 94.96 High High
Apoptosis 117 94.48 High High
Endometriosis 224 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Differentiation of naive CD4+ T cells by IL-7 and IL-4 is not impaired in RA patients
Positive_regulation (by) of Localization (Differentiation) of IL-4 in T cells associated with rheumatoid arthritis
1) Confidence 0.40 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.45 Pain Relevance 0.23
Neutralization of IL4 significantly enhanced the effectiveness of TRAIL in epithelial tumors [59], confirming that factors derived from the tumor microenvironment can diminish the response of tumor cells to TRAIL.
Positive_regulation (enhanced) of Localization (Neutralization) of IL4 associated with cancer
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.66 Pain Relevance 0
The majority of lidocaine-specific clones secreted rather high amounts of IL-5 and IL-4 after PMA/ionomycin stimulations (Th2-like), but some CD4+ and all CD8+ clones had a Th1-like phenotype (high INF-gamma and TNF-alpha).
Positive_regulation (amounts) of Localization (secreted) of IL-4 associated with lidocaine
3) Confidence 0.23 Published 1997 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 9130515 Disease Relevance 0.22 Pain Relevance 0.22
Interestingly, the treatment of children with allergic rhinitis with montelukast induces a significant decrease of nasal lavage IL-4 and IL-13 and a significant increase of IFN-?
Positive_regulation (induces) of Localization (decrease) of IL-4 in nasal associated with rhinitis
4) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.87 Pain Relevance 0.44
Interestingly, the treatment of children with allergic rhinitis with montelukast induces a significant decrease of nasal lavage IL-4 and IL-13 and a significant increase of IFN-?
Positive_regulation (increase) of Localization (decrease) of IL-4 in nasal associated with rhinitis
5) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.93 Pain Relevance 0.42
Interestingly, the treatment of children with allergic rhinitis with montelukast induces a significant decrease of nasal lavage IL-4 and IL-13 and a significant increase of IFN-?
Positive_regulation (lavage) of Localization (decrease) of IL-4 in nasal associated with rhinitis
6) Confidence 0.21 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.86 Pain Relevance 0.41
Decreased production of Interleukin(IL)-12, IL-2 and Interferon (IFN)-g accompanied by an increased secretion of IL-4 are the main features of this defective immunological response.
Positive_regulation (increased) of Localization (secretion) of IL-4
7) Confidence 0.10 Published 2006 Journal Curr. Med. Chem. Section Abstract Doc Link 17073638 Disease Relevance 1.29 Pain Relevance 0.14
Although higher concentrations of LPS (1000 ng/ml) failed to stimulate significant release of IL-4 and TGF-?
Neg (failed) Positive_regulation (stimulate) of Localization (release) of IL-4
8) Confidence 0.09 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2774314 Disease Relevance 0.13 Pain Relevance 0.09
Th2 responses are mediated through the secretion of a different set of cytokines, primarily interleukin-1, interleukin-4, interleukin-6, interleukin-10, and interleukin-13, and B cells, eosinophils, and mast cells [11].
Positive_regulation (mediated) of Localization (secretion) of interleukin-4 in eosinophils associated with cytokine
9) Confidence 0.08 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 0.89 Pain Relevance 0.38
In a second phase, cortisol enhances the recruitment of T-helper-2 cells, and subsequently released cytokines such as IL-2, IL-4 and IL-13 stimulate 11?
Positive_regulation (stimulate) of Localization (released) of IL-4 associated with cytokine
10) Confidence 0.08 Published 2004 Journal Crit Care Section Body Doc Link PMC522845 Disease Relevance 0.48 Pain Relevance 0.29
In addition, these cells play a critical role in sustaining Th2-mediated responses by secreting high levels of IL-4.
Positive_regulation (levels) of Localization (secreting) of IL-4
11) Confidence 0.04 Published 2007 Journal Semin Immunopathol Section Body Doc Link PMC2668599 Disease Relevance 0.61 Pain Relevance 0.18
Th2 responses are mediated through the secretion of a different set of cytokines, primarily interleukin-1, interleukin-4, interleukin-6, interleukin-10, and interleukin-13, and B cells, eosinophils, and mast cells [11].
Positive_regulation (mediated) of in B cells Localization (secretion) of interleukin-4 in eosinophils associated with cytokine
12) Confidence 0.03 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 0.89 Pain Relevance 0.38
Th2 responses are mediated through the secretion of a different set of cytokines, primarily interleukin-1, interleukin-4, interleukin-6, interleukin-10, and interleukin-13, and B cells, eosinophils, and mast cells [11].
Positive_regulation (mediated) of in mast cells Localization (secretion) of interleukin-4 in eosinophils associated with cytokine
13) Confidence 0.03 Published 2009 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2723676 Disease Relevance 0.89 Pain Relevance 0.38

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox