INT69156

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 21
Total Number 21
Disease Relevance 14.95
Pain Relevance 5.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL5) extracellular region (IL5)
Anatomy Link Frequency
lymphocytes 5
B cells 2
blood 1
immune cells 1
smooth muscle cells 1
IL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 708 100.00 Very High Very High Very High
lidocaine 2 99.66 Very High Very High Very High
chemokine 203 99.60 Very High Very High Very High
agonist 99 99.36 Very High Very High Very High
Inflammatory mediators 43 99.16 Very High Very High Very High
Inflammation 773 98.90 Very High Very High Very High
corticosteroid 31 95.68 Very High Very High Very High
tolerance 17 87.04 High High
Dopamine 10 86.48 High High
anesthesia 4 79.68 Quite High
Disease Link Frequency Relevance Heat
Asthma 1581 99.84 Very High Very High Very High
INFLAMMATION 878 98.90 Very High Very High Very High
Hypersensitivity 74 98.44 Very High Very High Very High
Disease 303 98.28 Very High Very High Very High
Infection 374 97.28 Very High Very High Very High
Neuromyelitis Optica 215 96.70 Very High Very High Very High
Necrosis 14 92.20 High High
Rheumatic Diseases 3 91.92 High High
Cancer 232 91.84 High High
Adhesions 48 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HHV-8 creates a microenvironment where by there is preferential recruitment of T cell type 2 (Th2) lymphocytes with the release of IL-4 and IL-5 cytokines, which polarizes the immune response towards an antibody predominant immune reaction [69].
Localization (release) of IL-5 in lymphocytes associated with cytokine
1) Confidence 0.68 Published 2005 Journal Virol J Section Body Doc Link PMC1243244 Disease Relevance 0.57 Pain Relevance 0.13
The majority of lidocaine-specific clones secreted rather high amounts of IL-5 and IL-4 after PMA/ionomycin stimulations (Th2-like), but some CD4+ and all CD8+ clones had a Th1-like phenotype (high INF-gamma and TNF-alpha).
Localization (secreted) of IL-5 associated with lidocaine
2) Confidence 0.50 Published 1997 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 9130515 Disease Relevance 0.21 Pain Relevance 0.22
Type 2 response is related to secretion of IL-4, IL-5, IL-9 and IL-13 which promote induction of IgE and allergic response.
Localization (secretion) of IL-5 associated with hypersensitivity
3) Confidence 0.42 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.98 Pain Relevance 0.41
T helper-2 (TH-2) lymphocytes release cytokines, including IL-4, IL-5 and IL-13, that have a range of actions, including eosinophil activation and immunoglobulin secretion from B cells.
Localization (release) of IL-5 in B cells associated with cytokine
4) Confidence 0.29 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 1.05 Pain Relevance 0.45
A recent study, however, has shown that human bronchial smooth muscle cells in culture, when passively sensitised with serum from patients with atopic asthma, can also express and secrete IL-5.
Localization (secrete) of IL-5 in smooth muscle cells associated with asthma
5) Confidence 0.26 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.02 Pain Relevance 0.28
It should be borne in mind, however, that the concentrations of IL-5 in these experiments were significantly higher than the concentrations of IL-5 secreted by the sensitised ASM cells into the culture medium.
Localization (secreted) of IL-5
6) Confidence 0.26 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.77 Pain Relevance 0.28
It should be borne in mind, however, that the concentrations of IL-5 in these experiments were significantly higher than the concentrations of IL-5 secreted by the sensitised ASM cells into the culture medium.
Localization (secreted) of IL-5
7) Confidence 0.24 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 0.85 Pain Relevance 0.31
Eosinophil production is activated by IL-5 released by the Th2 cells and in turn eosinophils also release lymphocyte active cytokines that can stimulate and affect the functioning of lymphocytes [82,103].
Localization (released) of IL-5 in lymphocytes associated with cytokine
8) Confidence 0.21 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1538622 Disease Relevance 0.39 Pain Relevance 0.05
Mediators (including histamine; cysteinyl leukotrienes; interleukin [IL]-4, IL-5, IL-13; regulated on activation, normal T-cell expressed and secreted [RANTES] chemokine; and eotaxin) are expressed in both upper and lower airways [14,15].
Localization (secreted) of IL-5 in upper associated with chemokine
9) Confidence 0.18 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 1.62 Pain Relevance 0.19
In vitro, selective PDE4 inhibitors inhibit proliferation and IL-4 and IL-5 secretion by human allergen-specific Th2 lymphocytes and Th1 and Th2 clones [34,56].
Localization (secretion) of IL-5 in lymphocytes
10) Confidence 0.16 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.18 Pain Relevance 0.16
2-agonists have been shown to inhibit the secretion of IL-4 and IL-5 in T cell lines [45].
Localization (secretion) of IL-5 in T cell associated with agonist
11) Confidence 0.14 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.51 Pain Relevance 0.42
, IL-4, IL-5, IL-8, RANTES and eotaxins, thought to be important in asthma pathogenesis, are regulated through activation of p38 MAPK. p38 MAPK can affect the transcription of these genes but also has major effects on mRNA stability.
Localization (important) of IL-5 associated with asthma
12) Confidence 0.14 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.89 Pain Relevance 0.43
Furthermore, in vitro, glucocorticoids inhibit proliferation and IL-4 and IL-5 secretion by human allergen-specific Th2 lymphocytes [17].
Localization (secretion) of IL-5 in lymphocytes
13) Confidence 0.14 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.22 Pain Relevance 0.08
Elevated PRL levels have been found to have proinflammatory effects [9] and activation of the prolactin receptor (PRL-R) has been shown to lead to the production and release of cytokines including IL-1, IL-4, IL-5, IL-6, IL-10 and INF-?
Localization (release) of IL-5 associated with cytokine
14) Confidence 0.12 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770548 Disease Relevance 0.84 Pain Relevance 0.32
Sensitization elevated allergen-specific IgE levels in serum, the number of CCR4-positive T helper lymphocytes in peripheral blood, and IL-4 and IL-5 releases from phorbol 12-myristate 13-acetate- and ionomycin-stimulated peripheral blood.
Localization (releases) of IL-5 in blood
15) Confidence 0.12 Published 2008 Journal J. Pharmacol. Sci. Section Abstract Doc Link 18187925 Disease Relevance 0.30 Pain Relevance 0.04
The following groups of cytokines were: inflammatory (GM-CSF, IL-1beta, IL-1RA, IL-6, IL-8, TNF-alpha); Th1/Th2 (IFN-gamma, IL-2, IL-2R, IL-4, IL-5, IL-10); Cytokine II (IFN-alpha, IL-7, IL-12p40/p70, IL-13, IL-15, IL-17); Chemokines (Eotaxin, IP-10, MCP-1, MIG, MIP-1alpha, MIP-1beta, RANTES); and Growth Factors (EGF, HGF, FGF-basic, G-CSF, VEGF).
Localization (/) of IL-5 in HGF associated with chemokine, inflammation and cytokine
16) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2625438 Disease Relevance 0.23 Pain Relevance 0.29
One of the plausible mechanisms put forward is immune deviation toward T-helper lymphocytes type 2 (Th2) cytokine characterized by secretion of IL-4, IL-5, IL-10 cytokines with reduced secretion of T-helper lymphocytes type 1 (Th1) cytokines namely IL-2, IL-12, and IFN-.[515–17]
Localization (secretion) of IL-5 in lymphocytes associated with cytokine
17) Confidence 0.06 Published 2010 Journal Asian Journal of Transfusion Science Section Body Doc Link PMC2937301 Disease Relevance 0.46 Pain Relevance 0.21
Although detection of NMO-IgG in CSF is rare, CSF of NMO patients, on average 4 years into what was characterized as aggressive disease, were found to contain anti-MOG antibody (IgM and IgG) cells, as well as mononuclear IL-5, IL6 secreting cells [10].
Localization (secreting) of IL-5 associated with neuromyelitis optica and disease
18) Confidence 0.06 Published 2008 Journal J Neuroinflammation Section Body Doc Link PMC2427020 Disease Relevance 1.32 Pain Relevance 0.27
SEB triggers immune cells to release Th2 cytokines IL-4, IL-5 and IL-13 [14,24-26] and enhances antigen-specific immune responses [19,27].
Localization (release) of IL-5 in immune cells associated with cytokine
19) Confidence 0.03 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1524974 Disease Relevance 0.99 Pain Relevance 0.22
Pathogen-associated molecular patterns on the surface of mycoplasmas engage TLRs 1, 2, and 6 on the surface of APCs that lead to a Th2-type polarization of the immune response and the secretion of IL-10, IL-4, IL-5 and IL-13 [178-180].
Localization (secretion) of IL-5
20) Confidence 0.03 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1386699 Disease Relevance 0.51 Pain Relevance 0.39

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