INT69157

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Context Info
Confidence 0.77
First Reported 1997
Last Reported 2010
Negated 5
Speculated 2
Reported most in Body
Documents 127
Total Number 129
Disease Relevance 102.58
Pain Relevance 26.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL5) extracellular region (IL5)
Anatomy Link Frequency
eosinophils 18
T cells 12
lung 8
Th2 cells 8
blood 5
IL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 4206 100.00 Very High Very High Very High
Inflammation 3945 100.00 Very High Very High Very High
chemokine 955 100.00 Very High Very High Very High
Nerve growth factor 30 99.72 Very High Very High Very High
lidocaine 27 99.66 Very High Very High Very High
fibrosis 122 99.52 Very High Very High Very High
Fibrositis 97 99.28 Very High Very High Very High
spastic colon 11 98.92 Very High Very High Very High
rheumatoid arthritis 151 98.76 Very High Very High Very High
nud 38 98.72 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 4280 100.00 Very High Very High Very High
Hyperplasia 257 99.96 Very High Very High Very High
Schistosomiasis 67 99.96 Very High Very High Very High
Targeted Disruption 546 99.88 Very High Very High Very High
Apoptosis 449 99.84 Very High Very High Very High
Asthma 9808 99.80 Very High Very High Very High
Strongyloidiasis 327 99.80 Very High Very High Very High
Eosinophilia 708 99.78 Very High Very High Very High
Hematological Disease 4 99.70 Very High Very High Very High
Nasal Polyps 67 99.54 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lidocaine does not affect IL-5R expression or IL-5-induced protein tyrosine phosphorylation.
Gene_expression (expression) of IL-5R associated with lidocaine
1) Confidence 0.77 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9558110 Disease Relevance 0.31 Pain Relevance 1.06
Assays were performed for IL-1, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, GM-CSF, TNF-?
Gene_expression (performed) of IL-5
2) Confidence 0.65 Published 2006 Journal Respir Res Section Body Doc Link PMC1578567 Disease Relevance 0 Pain Relevance 0.14
The spTCC derived from susceptible subjects (33 STCC) produced 10- to 1000-fold less IL-4 and IL-5 than TCC from resistant subjects (25 RTCC).
Gene_expression (produced) of IL-5
3) Confidence 0.62 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.52 Pain Relevance 0.04
Lidocaine does not affect IL-5R expression or IL-5-induced protein tyrosine phosphorylation.
Gene_expression (expression) of IL-5-induced associated with lidocaine
4) Confidence 0.60 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9558110 Disease Relevance 0.31 Pain Relevance 1.07
It is interesting that Liu and colleagues later showed a marked reduction in the expression of messenger ribonucleic acid of the surface IL-5 receptor (mIL-5R?)
Gene_expression (expression) of IL-5
5) Confidence 0.58 Published 2008 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2868889 Disease Relevance 0.40 Pain Relevance 0
As IgE and eosinophils are highly dependent on IL-4, Il-5 and IL-13, it was thought that protection against infection by Schistosoma would involve a Th2 immune response.
Gene_expression (dependent) of Il-5 in eosinophils associated with infection
6) Confidence 0.54 Published 2008 Journal Current Genomics Section Body Doc Link PMC2685643 Disease Relevance 0.29 Pain Relevance 0
High IL-5 production by human drug-specific T cell clones.
Gene_expression (production) of IL-5 in T cell
7) Confidence 0.48 Published 1997 Journal Int. Arch. Allergy Immunol. Section Title Doc Link 9130515 Disease Relevance 0.19 Pain Relevance 0.18
As helminthiasis, atopy is the result of aberrant Th2 cytokine response to allergens, with an increased production of IL-4, IL-13, Il-9 and Il-5, with high amounts of allergen-specific and total IgE and eosinophilia.
Gene_expression (production) of Il-5 associated with asthma, helminth infection, eosinophilia and cytokine
8) Confidence 0.48 Published 2008 Journal Current Genomics Section Abstract Doc Link PMC2685643 Disease Relevance 1.02 Pain Relevance 0.13
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Gene_expression (levels) of IL-5 in blood
9) Confidence 0.42 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.71 Pain Relevance 0.14
This observation correlates with the elevated levels of TLR3, 4, and 7, Th2 cytokines (IL6 and IL10) at protein level and IL4, IL5, IL6, IL10 at gene level.
Gene_expression (levels) of IL5 associated with cytokine
10) Confidence 0.41 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.14 Pain Relevance 0.19
Opposing effects of sodium salicylate and haematopoietic cytokines IL-3, IL-5 and GM-CSF on mitogen-activated protein kinases and apoptosis of EoL-1 cells.
Gene_expression (effects) of IL-5 associated with apoptosis and cytokine
11) Confidence 0.40 Published 1999 Journal Immunol. Invest. Section Title Doc Link 10574634 Disease Relevance 0.72 Pain Relevance 0.35
By contrast, BNL1059 and RGS1746 favoured production of IL-4 which is known to promote production of IgE [10] and, at a lesser extent, of IL-5 which specifically controls production and activation and localization of eosinophils, the major cause of tissue damage in atopic disease [11].
Gene_expression ([10) of IL-5 in eosinophils associated with disease
12) Confidence 0.37 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.44 Pain Relevance 0.20
By contrast, BNL1059 and RGS1746 favoured production of IL-4 which is known to promote production of IgE [10] and, at a lesser extent, of IL-5 which specifically controls production and activation and localization of eosinophils, the major cause of tissue damage in atopic disease [11].
Gene_expression (production) of IL-5 in eosinophils associated with disease
13) Confidence 0.37 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.44 Pain Relevance 0.20
They also showed a decrease in serum levels of sIL-2R, IL-4, IL-5, IgE and eosinophil count.
Gene_expression (levels) of IL-5 in eosinophil
14) Confidence 0.37 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.48 Pain Relevance 0.10
Jaffe JS et al. showed enhanced expression of IL-4, IL-5, and interferon gamma in the peripheral T cells of patients with allergic eosinophilic gastroenteritis [39].
Gene_expression (expression) of IL-5 in T cells associated with rhinitis, hypersensitivity and gastroenteritis
15) Confidence 0.36 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 1.26 Pain Relevance 0.19
Glucocorticoids decrease the levels of IL-5, which is one of the major growth factors for eosinophilic granulocytes (especially in eosinophilic conditions).
Gene_expression (levels) of IL-5 in granulocytes associated with rhinitis
16) Confidence 0.35 Published 2008 Journal Cases J Section Body Doc Link PMC2596115 Disease Relevance 0.89 Pain Relevance 0.23
Previous studies have demonstrated lower eosinophil counts, decreased production of IL-5, and increased production of interferon gamma in patients with S. stercoralis and HTLV-1 co-infection [10].
Gene_expression (production) of IL-5 in eosinophil associated with infection
17) Confidence 0.35 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.36 Pain Relevance 0
Furthermore, those with increased proportions of CD25+FoxP3+ cells had decreased antigen-driven production of IL-5 and lower eosinophil counts.
Gene_expression (production) of IL-5 in eosinophil
18) Confidence 0.35 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.22 Pain Relevance 0
This defect in immune host response is associated with lower eosinophil counts and decreased antigen-driven production of IL-5.
Gene_expression (production) of IL-5 in eosinophil
19) Confidence 0.35 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.72 Pain Relevance 0
The immunocompetent patients also produce IL-5 in response to stimulation with S. stercoralis larval antigens.
Gene_expression (produce) of IL-5
20) Confidence 0.35 Published 2009 Journal PLoS Neglected Tropical Diseases Section Body Doc Link PMC2686100 Disease Relevance 0.49 Pain Relevance 0.03

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