INT69158

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Context Info
Confidence 0.71
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 48
Total Number 49
Disease Relevance 31.30
Pain Relevance 11.98

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL4) extracellular region (IL4)
Anatomy Link Frequency
T cells 6
lymphocytes 3
Th2 cells 3
B cells 2
mast cells 2
IL4 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 1232 100.00 Very High Very High Very High
Enkephalin 17 100.00 Very High Very High Very High
Inflammation 1129 99.98 Very High Very High Very High
lidocaine 3 99.66 Very High Very High Very High
Inflammatory mediators 23 99.40 Very High Very High Very High
agonist 190 99.36 Very High Very High Very High
rheumatoid arthritis 125 99.20 Very High Very High Very High
antagonist 270 98.92 Very High Very High Very High
chemokine 194 96.84 Very High Very High Very High
endometriosis 336 96.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1232 99.98 Very High Very High Very High
Asthma 2634 99.84 Very High Very High Very High
Infection 411 99.82 Very High Very High Very High
Multiple Myeloma 27 99.48 Very High Very High Very High
Rheumatoid Arthritis 126 99.20 Very High Very High Very High
Rhinitis 98 99.20 Very High Very High Very High
Cancer 588 99.16 Very High Very High Very High
Necrosis 44 98.92 Very High Very High Very High
Hypersensitivity 188 97.68 Very High Very High Very High
Apoptosis 261 97.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Spontaneous secretion of IL-4 and IL-8 correlates with synthesis of nitric oxide, suggesting that NO and transitory S-nitrosylation of up-stream proteins participate in the sigma ligand dependent expression of IL-4 and IL-8 genes.
Localization (secretion) of IL-4
1) Confidence 0.71 Published 2005 Journal Georgian Med News Section Abstract Doc Link 16308450 Disease Relevance 0.07 Pain Relevance 0.30
Differentiation of naive CD4+ T cells by IL-7 and IL-4 is not impaired in RA patients
Localization (Differentiation) of IL-4 in T cells associated with rheumatoid arthritis
2) Confidence 0.60 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC193727 Disease Relevance 0.45 Pain Relevance 0.23
Secretion of met-enkephalin in the culture supernatant of IL-4- or IL-10-stimulated PBMC could not be observed, but proenkephalin A-derived met-enkephalin containing peptides could be demonstrated.
Localization (Secretion) of IL-4 in PBMC associated with enkephalin
3) Confidence 0.55 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9357452 Disease Relevance 0 Pain Relevance 0.46
Type 2 response is related to secretion of IL-4, IL-5, IL-9 and IL-13 which promote induction of IgE and allergic response.
Localization (secretion) of IL-4 associated with hypersensitivity
4) Confidence 0.43 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2848054 Disease Relevance 0.98 Pain Relevance 0.41
IL-4 and IL-13 given separately stimulated MCP-1, IL-6 and SCF secretion in a concentration (0.01 to 100 ng/ml) and time (0 to 24 hours) dependent manner.
Localization (secretion) of IL-4
5) Confidence 0.43 Published 2006 Journal J. Urol. Section Body Doc Link 16407046 Disease Relevance 0.13 Pain Relevance 0
T helper-2 (TH-2) lymphocytes release cytokines, including IL-4, IL-5 and IL-13, that have a range of actions, including eosinophil activation and immunoglobulin secretion from B cells.
Localization (release) of IL-4 in B cells associated with cytokine
6) Confidence 0.40 Published 2010 Journal BMC Pulm Med Section Body Doc Link PMC2820465 Disease Relevance 1.05 Pain Relevance 0.45
Neutralization of IL4 significantly enhanced the effectiveness of TRAIL in epithelial tumors [59], confirming that factors derived from the tumor microenvironment can diminish the response of tumor cells to TRAIL.
Localization (Neutralization) of IL4 associated with cancer
7) Confidence 0.40 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.60 Pain Relevance 0
The majority of lidocaine-specific clones secreted rather high amounts of IL-5 and IL-4 after PMA/ionomycin stimulations (Th2-like), but some CD4+ and all CD8+ clones had a Th1-like phenotype (high INF-gamma and TNF-alpha).
Localization (secreted) of IL-4 associated with lidocaine
8) Confidence 0.36 Published 1997 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 9130515 Disease Relevance 0.22 Pain Relevance 0.22
In vitro, the cysteinyl-leukotriene receptor antagonist pranlukast can concentration-dependently inhibit the release of Th2 cytokines (IL-3, IL-4, GM-CSF), but not of the Th1 cytokine IL-2, from mite allergen-stimulated PBMCs from asthmatic patients [37].
Localization (release) of IL-4 associated with asthma, antagonist and cytokine
9) Confidence 0.34 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.72 Pain Relevance 0.42
Furthermore, in vitro, glucocorticoids inhibit proliferation and IL-4 and IL-5 secretion by human allergen-specific Th2 lymphocytes [17].
Localization (secretion) of IL-4 in lymphocytes
10) Confidence 0.34 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.22 Pain Relevance 0.08
In vitro, selective PDE4 inhibitors inhibit proliferation and IL-4 and IL-5 secretion by human allergen-specific Th2 lymphocytes and Th1 and Th2 clones [34,56].
Localization (secretion) of IL-4 in lymphocytes
11) Confidence 0.34 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.18 Pain Relevance 0.16
The T cells from the CP group had a typical IL-2, IL-4 secreting pattern, while AP patients had a high IL-10, IFN-gamma and low IL-2, IL-4 population.
Localization (secreting) of IL-4 in T cells
12) Confidence 0.34 Published 2003 Journal ANZ J Surg Section Body Doc Link 12534743 Disease Relevance 0 Pain Relevance 0
IgE formation is stimulated by the release of interleukin 4 (IL-4) and interleukin 13 (IL-13) produced by several cell types including a subset of T-helper lymphocytes prevalent in atopy called Th2 cells (Guachat et al. 1990; de Vries et al. 1999).
Localization (release) of IL-4 in Th2 cells associated with asthma
13) Confidence 0.33 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 1.27 Pain Relevance 0.15
IgE formation is stimulated by the release of interleukin 4 (IL-4) and interleukin 13 (IL-13) produced by several cell types including a subset of T-helper lymphocytes prevalent in atopy called Th2 cells (Guachat et al. 1990; de Vries et al. 1999).
Localization (release) of interleukin 4 in Th2 cells associated with asthma
14) Confidence 0.33 Published 2008 Journal Core Evidence Section Body Doc Link PMC2899803 Disease Relevance 1.27 Pain Relevance 0.15
Interestingly, the treatment of children with allergic rhinitis with montelukast induces a significant decrease of nasal lavage IL-4 and IL-13 and a significant increase of IFN-?
Localization (decrease) of IL-4 in nasal associated with rhinitis
15) Confidence 0.32 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.86 Pain Relevance 0.41
, IL-4, IL-5, IL-8, RANTES and eotaxins, thought to be important in asthma pathogenesis, are regulated through activation of p38 MAPK. p38 MAPK can affect the transcription of these genes but also has major effects on mRNA stability.
Localization (important) of IL-4 associated with asthma
16) Confidence 0.32 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.89 Pain Relevance 0.43
2-agonists have been shown to inhibit the secretion of IL-4 and IL-5 in T cell lines [45].
Localization (secretion) of IL-4 in T cell associated with agonist
17) Confidence 0.32 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.51 Pain Relevance 0.42
These data support the potential utility of a dual IL-4 and IL-13 oligonucleotide inhibitor in asthma, and suggest that local inhibition of IL-4R?
Localization (utility) of IL-4 associated with asthma
18) Confidence 0.32 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 1.00 Pain Relevance 0.22
Important in this process is the release of more IL-4 and IL-13 from a number of different inflammatory cells including mast cells, as well as IL-9.
Localization (release) of IL-4 in mast cells associated with inflammation
19) Confidence 0.30 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.71 Pain Relevance 0.29
These events ultimately lead to the release of important cytokines such as IL-4 and IL-13 critical for immunoglobulin E (IgE) production.
Localization (release) of IL-4 associated with cytokine
20) Confidence 0.30 Published 2010 Journal Allergy, Asthma & Immunology Research Section Body Doc Link PMC2946700 Disease Relevance 0.69 Pain Relevance 0.31

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