INT69160

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Context Info
Confidence 0.65
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 41
Total Number 41
Disease Relevance 36.04
Pain Relevance 7.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL5) extracellular region (IL5)
Anatomy Link Frequency
eosinophils 5
T cells 5
blood 3
plasma 3
Th2 cells 2
IL5 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 1071 100.00 Very High Very High Very High
cytokine 1024 100.00 Very High Very High Very High
Multiple sclerosis 140 99.56 Very High Very High Very High
lidocaine 6 99.24 Very High Very High Very High
agonist 111 98.56 Very High Very High Very High
chemokine 238 98.18 Very High Very High Very High
abdominal pain 10 94.32 High High
methotrexate 24 93.60 High High
Inflammatory mediators 45 91.08 High High
dexamethasone 14 90.92 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 1192 100.00 Very High Very High Very High
Schistosomiasis 3 99.96 Very High Very High Very High
Eosinophilia 168 99.92 Very High Very High Very High
Common Cold 88 99.92 Very High Very High Very High
Strongyloidiasis 78 99.80 Very High Very High Very High
Pulmonary Disease 243 99.68 Very High Very High Very High
Demyelinating Disease 154 99.56 Very High Very High Very High
Chronic Disease 2 99.40 Very High Very High Very High
Asthma 2231 99.36 Very High Very High Very High
Eosinophilic Esophagitis 106 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This inhibition cannot be overcome by increasing concentrations of IL-5 and is not due to the blocking of Na+ channels by lidocaine.
Positive_regulation (increasing) of IL-5 associated with lidocaine
1) Confidence 0.65 Published 1998 Journal J. Immunol. Section Abstract Doc Link 9605159 Disease Relevance 0.37 Pain Relevance 0.40
Infection with helminithic parasites elicits eosinophilia by stimulation of Th2 cytokines, especially IL-5.
Positive_regulation (stimulation) of IL-5 associated with eosinophilia, infection and cytokine
2) Confidence 0.32 Published 2004 Journal Clin Mol Allergy Section Body Doc Link PMC425596 Disease Relevance 1.98 Pain Relevance 0.05
The majority of lidocaine-specific clones secreted rather high amounts of IL-5 and IL-4 after PMA/ionomycin stimulations (Th2-like), but some CD4+ and all CD8+ clones had a Th1-like phenotype (high INF-gamma and TNF-alpha).
Positive_regulation (amounts) of IL-5 associated with lidocaine
3) Confidence 0.31 Published 1997 Journal Int. Arch. Allergy Immunol. Section Abstract Doc Link 9130515 Disease Relevance 0.21 Pain Relevance 0.22
Systemically, the vaccine produced a 2-fold (P =.035) expansion of CD4+ T cells, a 3.5-fold (P =.039) expansion of natural killer (NK) cells, a 2.1-fold (P =.014) expansion of eosinophils, and a 1.6-fold (P =.049) increase in serum IL-5.
Positive_regulation (increase) of IL-5 in eosinophils
4) Confidence 0.31 Published 2003 Journal Blood Section Abstract Doc Link 12406881 Disease Relevance 0.82 Pain Relevance 0.15
High levels of IL-4, IL-5 and IL-13 mRNAs, peripheral blood eosinophil count and serum IgE level decreased after surgery and radiation and continued to decrease during cyclosporine therapy.
Positive_regulation (levels) of IL-5 in blood
5) Confidence 0.29 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2846923 Disease Relevance 0.71 Pain Relevance 0.14
The eosinophil attracting chemokines “Regulated upon Activation, Normal T-cell Expressed, and Secreted” (RANTES), eotaxin, and interleukin-5 (IL-5) have been reported to be increased during COPD exacerbations (Zhu et al 2001; Bocchino et al 2002; Rohde et al 2004; Fujimoto et al 2005).
Positive_regulation (increased) of interleukin-5 in T-cell associated with chemokine and pulmonary disease
6) Confidence 0.29 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 1.20 Pain Relevance 0.20
The eosinophil attracting chemokines “Regulated upon Activation, Normal T-cell Expressed, and Secreted” (RANTES), eotaxin, and interleukin-5 (IL-5) have been reported to be increased during COPD exacerbations (Zhu et al 2001; Bocchino et al 2002; Rohde et al 2004; Fujimoto et al 2005).
Positive_regulation (increased) of IL-5 in T-cell associated with chemokine and pulmonary disease
7) Confidence 0.25 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 1.19 Pain Relevance 0.20
This observation correlates with the elevated levels of TLR3, 4, and 7, Th2 cytokines (IL6 and IL10) at protein level and IL4, IL5, IL6, IL10 at gene level.
Positive_regulation (elevated) of IL5 associated with cytokine
8) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2948498 Disease Relevance 1.14 Pain Relevance 0.19
of human lymphocytes, exhibited a modest 18-fold increase in IL6 and IL5 (Muller and Brennan, 2009).
Positive_regulation (increase) of IL5 in lymphocytes
9) Confidence 0.22 Published 2010 Journal Toxicological Sciences Section Body Doc Link PMC2923281 Disease Relevance 0.09 Pain Relevance 0.32
Porto et al., in their effort to demonstrate the effect of HTLV-1 in patients with strongyloidiasis, noticed increased IL-5 in patients with strongyloidiasis [96].
Positive_regulation (increased) of IL-5 associated with strongyloidiasis
10) Confidence 0.21 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1538622 Disease Relevance 0.66 Pain Relevance 0
Supernatant collected from restimulated cells showed increased amounts of IL-4 (11.4-fold; P =.021) and IL-5 (8.7-fold; P =.002).
Positive_regulation (increased) of IL-5
11) Confidence 0.20 Published 2003 Journal Blood Section Abstract Doc Link 12406881 Disease Relevance 0.77 Pain Relevance 0.13
After exposure to DEHPhigh house dust ECP, G-CSF, IL-5, and/or IL-6 were not increased.
Neg (not) Positive_regulation (increased) of IL-5
12) Confidence 0.19 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592268 Disease Relevance 0.32 Pain Relevance 0.12
We found increases in ECP, G-CSF, IL-5, and/or IL-6 after exposure to DEHPlow house dust.
Positive_regulation (increases) of IL-5
13) Confidence 0.19 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2592268 Disease Relevance 0.34 Pain Relevance 0.13
BAL fluid samples isolated from atopic asthmatic patients also reveal significantly increased levels of IL-5 [18].
Positive_regulation (increased) of IL-5 associated with asthma
14) Confidence 0.15 Published 2002 Journal Respir Res Section Body Doc Link PMC64809 Disease Relevance 1.24 Pain Relevance 0.38
Cyclosporin A inhibits the allergen-induced late asthmatic reaction, the allergen-induced increase in IL-5 and GM-CSF in mRNA+ cells in BAL, and in the number of eosinophils in blood and bronchial mucosa, but not the early asthmatic reaction [8].
Positive_regulation (increase) of IL-5 in blood associated with asthma
15) Confidence 0.13 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.77 Pain Relevance 0.24
We have shown that after antigen challenge, there is an increase in IL-5-producing T cells in the bone marrow and an increase in high-affinity IL-5 receptor, which is associated with an elevated number of eosinophil progenitors [35,36].
Positive_regulation (increase) of IL-5-producing in T cells
16) Confidence 0.13 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 0.29 Pain Relevance 0.23
We have shown that after antigen challenge, there is an increase in IL-5-producing T cells in the bone marrow and an increase in high-affinity IL-5 receptor, which is associated with an elevated number of eosinophil progenitors [35,36].
Positive_regulation (increase) of IL-5 in T cells
17) Confidence 0.13 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 0.39 Pain Relevance 0.23
Increased levels of IL-3, IL-4, IL-5, granulocyte-macrophage colony-stimulating factor (GM-CSF), and eosinophils were found in endobronchial biopsy specimens from nonatopic asthma patients [24-27].
Positive_regulation (Increased) of IL-5 in eosinophils associated with asthma
18) Confidence 0.12 Published 2005 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2877070 Disease Relevance 2.53 Pain Relevance 0.22
In addition, BCE inhibited the IL-4, IL-5 and TNF-alpha mRNA induction by PMA and A23187 in human leukemia mast cells, HMC-1.
Positive_regulation (induction) of IL-5 in mast cells associated with leukemia
19) Confidence 0.11 Published 2004 Journal Immunopharmacol Immunotoxicol Section Abstract Doc Link 15209365 Disease Relevance 0.67 Pain Relevance 0.15
Interestingly, IL-5 was increased in the plasma of EoE subjects compared to that of GERD or HC.
Positive_regulation (increased) of IL-5 in plasma associated with gastroesophageal reflux disease and eosinophilic esophagitis
20) Confidence 0.11 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2976489 Disease Relevance 1.06 Pain Relevance 0

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