INT69166

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Context Info
Confidence 0.67
First Reported 1996
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 35
Total Number 35
Disease Relevance 8.41
Pain Relevance 13.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (P2ry1) aging (P2ry1) plasma membrane (P2ry1)
signal transducer activity (P2ry1)
Anatomy Link Frequency
dura mater 2
central nervous system 2
spinal 2
sensory neurons 2
neuronal 2
P2ry1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Dopamine 348 99.80 Very High Very High Very High
agonist 219 99.76 Very High Very High Very High
Central nervous system 63 99.68 Very High Very High Very High
nMDA receptor 53 99.60 Very High Very High Very High
Nucleus accumbens 188 99.52 Very High Very High Very High
Neurotransmitter 141 99.38 Very High Very High Very High
antagonist 235 99.12 Very High Very High Very High
noradrenaline 49 98.88 Very High Very High Very High
Glutamate 206 98.84 Very High Very High Very High
qutenza 29 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 88 99.00 Very High Very High Very High
Injury 88 98.20 Very High Very High Very High
Low Back Pain 5 97.00 Very High Very High Very High
Increased Venous Pressure Under Development 4 96.92 Very High Very High Very High
Proliferative Vitreoretinopathy 1 96.84 Very High Very High Very High
Pain 56 95.88 Very High Very High Very High
Hypoxia 23 94.96 High High
Disease 11 94.48 High High
Amyloid Plaque 1 92.88 High High
Nerve Compression Syndromes 135 92.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P2Y(1) receptor activation inhibits NMDA receptor-channels in layer V pyramidal neurons of the rat prefrontal and parietal cortex.
Positive_regulation (activation) of P2Y in pyramidal neurons associated with pyramidal cell and nmda receptor
1) Confidence 0.67 Published 2003 Journal Neurochem. Int. Section Title Doc Link 12421596 Disease Relevance 0.07 Pain Relevance 0.18
We conclude that P2Y(2) receptor activation can maintain TRPV1 function perhaps during sustained episodes of activity of kidney projecting sensory neurons.
Positive_regulation (activation) of P2Y in kidney
2) Confidence 0.67 Published 2010 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 20335377 Disease Relevance 0 Pain Relevance 0.49
Taken together, these results suggest that the activation of UTP-sensitive P2Y(2) and/or P2Y(4) receptors and the UDP-sensitive P2Y(6) receptor, in contrast to P2X receptors, produces inhibitory effects on spinal pain transmission.
Positive_regulation (activation) of P2Y in spinal associated with low back pain and pain
3) Confidence 0.67 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12235234 Disease Relevance 0.74 Pain Relevance 0.84
ATP augments peptide release from rat sensory neurons in culture through activation of P2Y receptors.
Positive_regulation (activation) of P2Y in sensory neurons
4) Confidence 0.67 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 12829729 Disease Relevance 0 Pain Relevance 0.31
Increased activation of P2Y1Rs may also contribute to inhibition of neuronal hyperexcitability [24].
Positive_regulation (activation) of P2Y1Rs in neuronal associated with hyperexcitability
5) Confidence 0.54 Published 2008 Journal Mol Pain Section Body Doc Link PMC2630978 Disease Relevance 1.08 Pain Relevance 0.53
These data establish in neonatal rats that respiratory rhythm generating networks in the preBötC are exquisitely sensitive to P2Y1R activation, and suggest a role for P2Y1Rs in respiratory motor control, particularly in the P2R excitation of rhythm that occurs during hypoxia.
Positive_regulation (activation) of P2Y1R in respiratory associated with hypoxia
6) Confidence 0.49 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17267553 Disease Relevance 0.15 Pain Relevance 0.33
UTP activates three P2Y receptors: P2Y2 receptor that is activated equipotently by ATP and UTP, P2Y4 receptor most potently activated by UTP, and the P2Y6 receptor that can be selectively activated by UDP.
Positive_regulation (activates) of P2Y
7) Confidence 0.49 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.30
It has been reported that extracellular ATP potentiates the TRPV1 currents evoked by capsaicin or protons and reduces the temperature threshold for its activation through metabotropic P2Y receptors in a PKC-dependent pathway, suggesting that TRPV1 activation could trigger the sensation of pain at normal body temperature in the presence of ATP.
Positive_regulation (activation) of P2Y in body associated with pain and qutenza
8) Confidence 0.49 Published 2003 Journal J. Neurosci. Section Abstract Doc Link 12853424 Disease Relevance 0.48 Pain Relevance 0.56
ATP activates vasoconstrictory P2X- and vasodilatory P2Y-receptors in human renal blood vessels.
Positive_regulation (activates) of P2Y in renal blood vessels
9) Confidence 0.49 Published 1996 Journal J Auton Pharmacol Section Abstract Doc Link 9131419 Disease Relevance 0.09 Pain Relevance 0.37
Taken together, these results suggest that the activation of UTP-sensitive P2Y(2) and/or P2Y(4) receptors and the UDP-sensitive P2Y(6) receptor, in contrast to P2X receptors, produces inhibitory effects on spinal pain transmission.
Positive_regulation (activation) of P2Y in spinal associated with low back pain and pain
10) Confidence 0.49 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12235234 Disease Relevance 0.74 Pain Relevance 0.85
ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater.
Positive_regulation (enhance) of P2Y in dura mater
11) Confidence 0.49 Published 2002 Journal Pain Section Title Doc Link 12044622 Disease Relevance 0.27 Pain Relevance 0.21
ATP can enhance the proton-induced CGRP release through P2Y receptors and secondary PGE(2) release in isolated rat dura mater.
Positive_regulation (proton-induced) of P2Y in dura mater
12) Confidence 0.49 Published 2002 Journal Pain Section Title Doc Link 12044622 Disease Relevance 0.27 Pain Relevance 0.21
ATP, as a neurotransmitter released from sensory nerves, activates P2Y-purinoceptors located on the endothelium and stimulates the NO/cyclic GMP pathway, resulting in vasodilatation.
Positive_regulation (activates) of P2Y in endothelium associated with neurotransmitter and increased venous pressure under development
13) Confidence 0.49 Published 2000 Journal J. Pharm. Pharmacol. Section Abstract Doc Link 10813551 Disease Relevance 0.27 Pain Relevance 0.29
ATP and UTP can activate several P2X and P2Y receptors (Fields and Burnstock, 2006).
Positive_regulation (activate) of P2Y
14) Confidence 0.49 Published 2008 Journal The Journal of General Physiology Section Body Doc Link PMC2518726 Disease Relevance 0 Pain Relevance 0.30
Recently, we identified ATP and adenosine diphosphate (ADP) as agents able to control differentiation and promote migration of oligodendrocyte progenitors by activation of P2Y1 receptors [15].
Positive_regulation (activation) of P2Y1 in oligodendrocyte associated with adenocard
15) Confidence 0.46 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2096653 Disease Relevance 0.20 Pain Relevance 0.31
During mucosal mechanical reflexes, it is postulated that P2Y1 R, P2Y2 R, and P2Y4 R are activated by endogenous ATP, UTP, and 5'uridine-diphosphate.
Positive_regulation (activated) of P2Y1
16) Confidence 0.44 Published 2004 Journal J. Comp. Neurol. Section Abstract Doc Link 14689471 Disease Relevance 0 Pain Relevance 0.18
An immunohistochemical study has shown that behaviorally amphetamine-sensitized rats expressed an enhancement of P2Y1 receptor immunoreactivity on astrocytes and neurons as well as and astrogliosis.
Positive_regulation (enhancement) of P2Y1 in neurons
17) Confidence 0.44 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0.12 Pain Relevance 0.30
However, a long-lasting food deprivation caused an increase of the P2Y1 receptor mRNA in the accumbal region, thought to be a reflection of reduced stimulation of P2 receptors, in correlation to the reported reduced accumbal release of dopamine in food deprived rats [140].
Positive_regulation (increase) of P2Y1 receptor mRNA associated with dopamine
18) Confidence 0.41 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0.26 Pain Relevance 0.39
Therefore, a facilitatory effect of ADP/ATP on the accumbal dopamine level by stimulation of P2Y1 receptors can be assumed.
Positive_regulation (stimulation) of P2Y1 associated with dopamine
19) Confidence 0.41 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.51
Therefore, it is tentatively suggested that the effects of endogenous ADP/ATP on transmitter release in the NAc may be mediated by the activation of P2Y1 receptors leading to a stimulation of phospholipase C, the production of inositol-1,4,5-trisphosphate and the mobilization of intracellular Ca2+ resulting in a stimulation of neuronal exocytosis.
Positive_regulation (activation) of P2Y1 in neuronal associated with nucleus accumbens
20) Confidence 0.41 Published 2004 Journal Purinergic Signal Section Body Doc Link PMC2096569 Disease Relevance 0 Pain Relevance 0.43

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