INT69181

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Context Info
Confidence 0.33
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 5.54
Pain Relevance 1.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col3a1) extracellular region (Col3a1)
Anatomy Link Frequency
ligaments 1
sensory neurons 1
epithelial cell 1
bladder 1
lung 1
Col3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
sodium channel 3 99.98 Very High Very High Very High
fibrosis 24 98.68 Very High Very High Very High
Morphine 13 97.92 Very High Very High Very High
nalbuphine 1 92.52 High High
Sciatic nerve 1 79.60 Quite High
Kinase C inhibitor 1 79.52 Quite High
metalloproteinase 8 75.60 Quite High
tetrodotoxin 4 75.00 Quite High
imagery 7 61.20 Quite High
addiction 2 59.68 Quite High
Disease Link Frequency Relevance Heat
Sepsis 25 100.00 Very High Very High Very High
Adhesions 14 100.00 Very High Very High Very High
Apoptosis 14 100.00 Very High Very High Very High
Adult Respiratory Distress Syndrome 59 99.96 Very High Very High Very High
Cicatrix 20 99.06 Very High Very High Very High
Stress 221 98.80 Very High Very High Very High
Fibrosis 23 98.68 Very High Very High Very High
Pulmonary Edema 7 98.20 Very High Very High Very High
Pressure Volume 2 Under Development 71 93.88 High High
Injury 46 93.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Morphine enhanced the accumulation of collagen type I in a dose-dependent manner and also increased (p < 0.001) the accumulation of collagen type III at a high concentration (control, 1,291+/-55.8 vs. morphine, 10(-4) M, 2,697.6+/-257.8 ng/microg protein).
Positive_regulation (accumulation) of collagen type III associated with morphine
1) Confidence 0.33 Published 1997 Journal Nephron Section Abstract Doc Link 9346391 Disease Relevance 0.14 Pain Relevance 1.24
The level of collagen type III also significantly increased in the 14-day and the 28-day stress groups.
Positive_regulation (increased) of collagen type III associated with stress
2) Confidence 0.14 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 1.02 Pain Relevance 0.03
The increased accumulation of collagen I and III has been associated mostly with fibrosis [18], [19].
Positive_regulation (accumulation) of collagen I and III associated with fibrosis
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.46 Pain Relevance 0.14
This study showed a significant increase in types I and III collagen in bladder tissue in the 14-day and 28-day stress groups compared with the control group.
Positive_regulation (increase) of III collagen in bladder associated with stress
4) Confidence 0.12 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 0.92 Pain Relevance 0.04
In acute lung injury (ALI), elevation of procollagen type III (PC III) occurs early and has an adverse impact on outcome.
Positive_regulation (elevation) of procollagen type III in lung associated with adult respiratory distress syndrome
5) Confidence 0.09 Published 2007 Journal Crit Care Section Abstract Doc Link PMC2151905 Disease Relevance 0.46 Pain Relevance 0
We have demonstrated previously that sodium channel alpha-III mRNA levels are elevated and sodium channel alpha-SNS mRNA levels are reduced in rat spinal sensory neurons after axotomy.
Positive_regulation (elevated) of alpha-III mRNA in sensory neurons associated with sodium channel
6) Confidence 0.07 Published 1997 Journal J. Neurosci. Section Abstract Doc Link 9133375 Disease Relevance 0.17 Pain Relevance 0.43
, caspase-3, type III procollagen (PCIII), intercellular adhesion molecule 1 (ICAM-1), and vascular cell adhesion molecule 1 (VCAM-1) mRNA expressions in lung tissue, as well as lung and distal organ epithelial cell apoptosis in an experimental model of sepsis-induced ALI.


Positive_regulation (induced) of type III procollagen in epithelial cell associated with adult respiratory distress syndrome, apoptosis, sepsis and adhesions
7) Confidence 0.06 Published 2010 Journal Crit Care Section Body Doc Link PMC2911760 Disease Relevance 1.75 Pain Relevance 0
Furthermore, the expression of collagen type I and type III mRNA, and collagen accumulation in the infarcted area was lower, which was associated with decreased TGF-?
Positive_regulation (accumulation) of collagen type I and type III mRNA
8) Confidence 0.05 Published 2009 Journal Mol Biol Rep Section Abstract Doc Link PMC2831180 Disease Relevance 0.44 Pain Relevance 0
Densitometry analysis further confirmed an increase in type-I collagen since the ratio of type-I to type-III collagen was significantly increased in tissues from ambulatory animals treated with IGF-I (p = 0.0129) and in unloaded tissues from GH+IGF-I treated animals (p = 0.0131), with a trend of increased levels in ambulatory GH+IGF and HU + IGF tissues (Fig. 7).
Positive_regulation (increased) of III collagen
9) Confidence 0.02 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.08 Pain Relevance 0.03
Since normal ligaments are primarily composed of type I collagen and the scar region of normal healing ligaments contain an increase in type III collagen [41] that is remodeled to transition to more type I collagen rich region over the healing period, changes in the type I to III ratio are a measure of healing and may indicate part of the structural mechanism resulting in the observed differences in mechanical properties following treatment.
Positive_regulation (increase) of III collagen in ligaments associated with cicatrix
10) Confidence 0.02 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1851714 Disease Relevance 0.10 Pain Relevance 0

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