INT69203

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Context Info
Confidence 0.66
First Reported 1997
Last Reported 2010
Negated 6
Speculated 1
Reported most in Abstract
Documents 43
Total Number 45
Disease Relevance 19.16
Pain Relevance 16.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Anatomy Link Frequency
brain 4
neurons 4
spinal cord 3
bladder 3
ciliary 2
Ntf3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 622 100.00 Very High Very High Very High
Nerve growth factor 528 100.00 Very High Very High Very High
bDMF 122 100.00 Very High Very High Very High
Central nervous system 50 100.00 Very High Very High Very High
neurotrophin 3 22 100.00 Very High Very High Very High
Inflammation 110 99.88 Very High Very High Very High
Somatostatin 7 99.84 Very High Very High Very High
Substantia nigra 6 99.68 Very High Very High Very High
addiction 17 99.54 Very High Very High Very High
Neuropeptide 7 98.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 10 100.00 Very High Very High Very High
Apoptosis 9 100.00 Very High Very High Very High
Retinal Degeneration 29 99.92 Very High Very High Very High
INFLAMMATION 116 99.86 Very High Very High Very High
Hydrocephalus 196 99.84 Very High Very High Very High
Brain Injury 25 99.68 Very High Very High Very High
Hypertrophy 2 99.62 Very High Very High Very High
Generalized Anxiety Disorder 3 99.54 Very High Very High Very High
Bacterial Meningitis 7 98.76 Very High Very High Very High
Injury 160 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Quantitative analysis showed that the levels of mRNAs for NT3 and NGF increased in ipsilateral but not contralateral DRG after nerve injury.
Positive_regulation (increased) of NT3 in DRG associated with nervous system injury and nerve growth factor
1) Confidence 0.66 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10215925 Disease Relevance 0.59 Pain Relevance 0.41
Here, we show that brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), but not nerve growth factor or neurotrophin-4, are upregulated in the spinal gray matter after DRI.
Positive_regulation (upregulated) of neurotrophin-3 in brain associated with nerve growth factor and injury
2) Confidence 0.62 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17522325 Disease Relevance 0.62 Pain Relevance 0.20
Neurotrophins-signaling pathways such as brain derived neurotrophic factor (BDNF) and Neurotrophin-3 (NT-3) play a key role for regulating the noradrenergic response of LC neurons to opiates.
Positive_regulation (derived) of NT-3 in neurons associated with locus ceruleus, opiate and bdmf
3) Confidence 0.48 Published 2007 Journal Neuropeptides Section Abstract Doc Link 17688944 Disease Relevance 0.23 Pain Relevance 1.37
Here, we show that brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), but not nerve growth factor or neurotrophin-4, are upregulated in the spinal gray matter after DRI.
Positive_regulation (upregulated) of NT-3 in brain associated with nerve growth factor and injury
4) Confidence 0.44 Published 2007 Journal J. Neurosci. Section Abstract Doc Link 17522325 Disease Relevance 0.61 Pain Relevance 0.19
Using in situ hybridization and immunohistochemical techniques, we have now found that nerve growth factor (NGF) and neurotrophin-3 (NT3) synthesis is upregulated in satellite cells surrounding neurons in lesioned DRG as early as 48 h after nerve injury.
Positive_regulation (upregulated) of NT3 in nerve associated with nervous system injury and nerve growth factor
5) Confidence 0.44 Published 1999 Journal Eur. J. Neurosci. Section Abstract Doc Link 10215925 Disease Relevance 0.60 Pain Relevance 0.39
The results showed that receptors for brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor were upregulated and that these trophic factors promoted survival and axonal regeneration of motoneurons when they were injected into the sensory nerve graft before implantation.
Positive_regulation (derived) of neurotrophic factor in sensory nerve
6) Confidence 0.44 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19104442 Disease Relevance 0 Pain Relevance 0
In contrast, receptors for ciliary neurotrophic factor and pleiotrophin were downregulated after avulsion.
Positive_regulation (ciliary) of neurotrophic factor in ciliary
7) Confidence 0.44 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19104442 Disease Relevance 0 Pain Relevance 0
HFES of sympathetic neurons induced a frequency dependent NGF and NT-3 gene and protein up-regulation (relative NGF protein expression: 0Hz=1+/-0.0 vs. 5Hz=1.13+/-0.19 vs. 50Hz=1.77+/-0.08, all n=5, 0Hz/5Hz vs. 50Hz p<0.05), with a subsequent increase of growth associated protein 43 (GAP-43) expression and morphological SNS.
Positive_regulation (up-regulation) of NT-3 gene in neurons associated with nerve growth factor
8) Confidence 0.43 Published 2010 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 20138055 Disease Relevance 0.31 Pain Relevance 0.44
NGF and NT-3 concentrations are increased in children with hydrocephalus.
Positive_regulation (increased) of NT-3 associated with nerve growth factor and hydrocephalus
9) Confidence 0.43 Published 2001 Journal BMC Pediatr Section Abstract Doc Link PMC57003 Disease Relevance 0.74 Pain Relevance 0.39
NGF and NT-3 concentrations are markedly elevated in CSF of children with hydrocephalus.
Positive_regulation (elevated) of NT-3 associated with nerve growth factor and hydrocephalus
10) Confidence 0.43 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.82 Pain Relevance 0.67
NT-3 has been reported to be increased in the CSF from patients with bacterial meningitis [8,9] and in four infants undergoing shunt placement for hydrocephalus [9].
Positive_regulation (increased) of NT-3 associated with bacterial meningitis and hydrocephalus
11) Confidence 0.43 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 1.45 Pain Relevance 0.44
We found a significant increase of NGF, BDNF and NT-3 transcripts and NGF proteins in both the NSC cultures and the CSF of the rats.
Positive_regulation (increase) of NT-3 in CSF associated with nerve growth factor
12) Confidence 0.42 Published 2010 Journal J Transl Med Section Abstract Doc Link PMC2936305 Disease Relevance 0.15 Pain Relevance 0.38
Therefore, the therapeutic effects of MSC transplantation on NCV would not be mediated through NGF or NT-3.
Neg (not) Positive_regulation (mediated) of NT-3 associated with neurotrophin 3 and nerve growth factor
13) Confidence 0.42 Published 2008 Journal Diabetes Section Body Doc Link PMC2570407 Disease Relevance 0.41 Pain Relevance 0.47
The results showed that receptors for brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor were upregulated and that these trophic factors promoted survival and axonal regeneration of motoneurons when they were injected into the sensory nerve graft before implantation.
Positive_regulation (upregulated) of neurotrophic factor in sensory nerve
14) Confidence 0.40 Published 2009 Journal J. Neuropathol. Exp. Neurol. Section Abstract Doc Link 19104442 Disease Relevance 0 Pain Relevance 0
In neonatal rat atrial myocytes, HFES resulted in myocyte hypertrophy accompanied by an increase in NT-3 and a decrease in NGF expression.
Positive_regulation (increase) of NT-3 in myocytes associated with hypertrophy and nerve growth factor
15) Confidence 0.38 Published 2010 Journal J. Mol. Cell. Cardiol. Section Abstract Doc Link 20138055 Disease Relevance 0.10 Pain Relevance 0.41
NGF and NT-3 concentrations were greatly elevated in hydrocephalus CSF samples, as compared to controls (Fig. 1, Fig. 2).
Positive_regulation (elevated) of NT-3 associated with nerve growth factor and hydrocephalus
16) Confidence 0.37 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.77 Pain Relevance 0.29
Because transcription from this plasmid results in the production of one mRNA encoding both proteins, cell sorting for cells expressing high levels of EGFP protein was used in order to obtain an hMSC-NT3-EGFP line producing high levels of EGFP and NT3 mRNA (Figure 1C, hMSC-NT3-EGFP cells) and EGFP and NT3 protein (Figure 1D and 1E, hMSC-NT3-EGFP cells).
Positive_regulation (levels) of NT3
17) Confidence 0.33 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.22 Pain Relevance 0.12
Despite significant production of NT3 by the selected hMSC-NT3 clone, only very low, but however significant, NT3 mRNA was produced by these cells (Figure 1C, hMSC-NT3 cells).
Positive_regulation (produced) of NT3
18) Confidence 0.31 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.22 Pain Relevance 0.10
Despite significant production of NT3 by the selected hMSC-NT3 clone, only very low, but however significant, NT3 mRNA was produced by these cells (Figure 1C, hMSC-NT3 cells).
Positive_regulation (selected) of hMSC-NT3
19) Confidence 0.29 Published 2007 Journal BMC Biotechnol Section Body Doc Link PMC2225398 Disease Relevance 0.20 Pain Relevance 0.10
While our investigation demonstrates increased NGF and NT-3 CSF concentrations in a considerable proportion of infants and children with hydrocephalus, the association of this finding with elevated intracranial pressure is not formally proven and therefore remains hypothetical.
Positive_regulation (increased) of NT-3 associated with intracranial hypertension, nerve growth factor, hydrocephalus and cva
20) Confidence 0.28 Published 2001 Journal BMC Pediatr Section Body Doc Link PMC57003 Disease Relevance 0.54 Pain Relevance 0.64

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