INT69215

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 38
Total Number 42
Disease Relevance 17.39
Pain Relevance 4.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Col1a1) extracellular region (Col1a1) proteinaceous extracellular matrix (Col1a1)
molecular_function (Col1a1) cytoplasm (Col1a1)
Anatomy Link Frequency
smooth muscle 2
PSCs 2
tendons 2
kidney 2
hindlimb 2
Col1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 148 100.00 Very High Very High Very High
Snapping jaw 4 99.52 Very High Very High Very High
fibrosis 235 97.90 Very High Very High Very High
Inflammation 245 97.64 Very High Very High Very High
Calcitonin gene-related peptide 1 97.56 Very High Very High Very High
agonist 20 96.72 Very High Very High Very High
substance P 1 96.12 Very High Very High Very High
cytokine 115 95.16 Very High Very High Very High
anesthesia 15 93.00 High High
antagonist 11 88.80 High High
Disease Link Frequency Relevance Heat
Fibrosis 241 100.00 Very High Very High Very High
Osteoporosis 73 100.00 Very High Very High Very High
Primary Sclerosing Cholangitis 13 99.98 Very High Very High Very High
Temporomandibular Joint Syndrome 4 99.52 Very High Very High Very High
Stress 337 99.44 Very High Very High Very High
Hypoxia 78 99.44 Very High Very High Very High
Proteinuria 20 99.36 Very High Very High Very High
INFLAMMATION 266 97.64 Very High Very High Very High
Hypercalcemia 14 97.62 Very High Very High Very High
Hypertrophy 16 97.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of type I collagen, osteocalcin and MMPs 2 and 13 increased toward week 2 and decreased thereafter, whereas the expression of MMP 8 was the highest on day 1.
Gene_expression (expression) of type I collagen associated with metalloproteinase
1) Confidence 0.68 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.37
The study examined the expression of matrix metalloproteinases (MMPs), type I collagen and osteocalcin during bone healing in a rat calvarial experimental defect model.
Spec (examined) Gene_expression (expression) of type I collagen associated with metalloproteinase
2) Confidence 0.68 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.24
Gene expression of collagen type I and transforming growth factor beta1 was shown by Northern blot analysis.
Gene_expression (expression) of collagen type I
3) Confidence 0.62 Published 1997 Journal Gastroenterology Section Body Doc Link 9136846 Disease Relevance 0.09 Pain Relevance 0
RNA was extracted from tissue that filled the original bone defect on days 1 and 3 and in weeks 1, 2, 3, 5, 8, 10, 12, 18, and 24 and processed for quantitative analysis of expression of type I collagen, osteocalcin and matrix metalloproteinases (MMPs) 2, 8, and 13 by using real-time polymerase chain reaction.
Gene_expression (expression) of type I collagen associated with metalloproteinase
4) Confidence 0.60 Published 2008 Journal Anatomical record (Hoboken, N.J. : 2007) Section Abstract Doc Link 18615687 Disease Relevance 0 Pain Relevance 0.34
The distribution of collagen types I and II appeared normal in the tendon and its insertion to the calcaneus.
Gene_expression (distribution) of collagen types I in tendon
5) Confidence 0.51 Published 1999 Journal Cells Tissues Organs (Print) Section Abstract Doc Link 10460971 Disease Relevance 0.25 Pain Relevance 0.21
Fibrosis was reduced in 30% of patients by the end of the 12-month treatment, and mRNAs coding for profibrogenic molecules such as COL1A1, TGF-?
Gene_expression (molecules) of COL1A1 associated with fibrosis
6) Confidence 0.39 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 1.62 Pain Relevance 0.32
Expressions of "fetal type" genes and type 1 collagen gene were examined by Northern blot analysis.
Spec (examined) Gene_expression (Expressions) of type 1 collagen
7) Confidence 0.35 Published 1998 Journal Hypertension Section Abstract Doc Link 9449387 Disease Relevance 0.40 Pain Relevance 0.26
Nicorandil significantly prevented the overexpression of type I collagen, fibronectin, transforming growth factor (TGF)-beta, and platelet-derived growth factor (PDGF) mRNA.
Gene_expression (overexpression) of type I collagen in platelet
8) Confidence 0.35 Published 2009 Journal J. Pharmacol. Sci. Section Abstract Doc Link 19721333 Disease Relevance 1.17 Pain Relevance 0.07
The combination of both agents produced an improvement in adsorption droplets and proteinuria in the glomeruli, and cortical collagen I mRNA expression was also significantly decreased.
Gene_expression (expression) of collagen I mRNA associated with proteinuria
9) Confidence 0.35 Published 2010 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2944211 Disease Relevance 0.85 Pain Relevance 0.16
Although the expression of collagen type I in the 7-day stress group did not significantly increase compared with that of the control group, such expression significantly increased as the duration of stress exposure increased to 28 days.
Gene_expression (expression) of collagen type I associated with stress
10) Confidence 0.34 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 1.04 Pain Relevance 0.06
Mann found that presence of the T allele in the COLIA1 Sp1 binding site has functional effects on the collagen gene regulation that leads to a higher COLIA1 mRNA expression level, an increase COLIA1 protein expression level and COLIA1/COLIA2 protein ratios 25.
Gene_expression (expression) of COLIA1
11) Confidence 0.32 Published 2008 Journal International Journal of Biological Sciences Section Body Doc Link PMC2532796 Disease Relevance 0.69 Pain Relevance 0
Collagen I and II mRNA distribution in the rat temporomandibular joint region during growth.
Gene_expression (distribution) of Collagen I in temporomandibular joint associated with snapping jaw
12) Confidence 0.31 Published 2000 Journal J. Craniofac. Genet. Dev. Biol. Section Title Doc Link 11321599 Disease Relevance 0.37 Pain Relevance 0.37
RESULTS: High glucose concentrations significantly increased PSC proliferation, alpha-SMA expression, and collagen type I production in PSCs.
Gene_expression (production) of collagen type I in PSCs
13) Confidence 0.30 Published 2007 Journal Pancreas Section Body Doc Link 17414061 Disease Relevance 0.16 Pain Relevance 0
Moreover, pressure significantly promoted activated TGF-beta1 secretion, collagen type I mRNA expression, and collagen secretion.
Gene_expression (expression) of collagen type I mRNA
14) Confidence 0.27 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0 Pain Relevance 0.13
Collagen type I mRNA expression and collagen secretion were assessed by quantitative PCR and Sirius red dye binding assay, respectively.
Gene_expression (expression) of Collagen type I mRNA
15) Confidence 0.27 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.14 Pain Relevance 0.10
Comparing the expression of collagen type I among the control and the three stress groups, a significant difference was noted in the 14-day and 28-day stress groups, p=0.003, p=0.047, respectively.
Gene_expression (expression) of collagen type I associated with stress
16) Confidence 0.27 Published 2010 Journal Korean Journal of Urology Section Body Doc Link PMC2855479 Disease Relevance 1.14 Pain Relevance 0
Other secondary endpoints were changes in BMD at the total hip, femoral neck, and lumbar spine, and changes in markers of bone resorption (serum C-telopeptide of type I collagen, CTX) and formation (bone-specific alkaline phosphatase, BSAP, and N-terminal propeptide of type I collagen, PINP).
Gene_expression (propeptide) of type I collagen in neck associated with hypercalcemia
17) Confidence 0.22 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697536 Disease Relevance 0.41 Pain Relevance 0
Transcriptional expressions of several osteoblast-related genes (RUNX2, SP7, SPP1, COLIA1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cell markers (ENG) were examined after seven days of treatment with osteoplant.
Spec (examined) Gene_expression (expressions) of COLIA1 in stem cell associated with osteoporosis
18) Confidence 0.14 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.10 Pain Relevance 0
In order to get a better insight into how the osteoplant acts on PB-hMSCs, changes in expression of bone-related marker genes (RUNX2, SP7, SPP1, COLIA1, COL3A1, BGLAP, ALPL, and FOSL1) and mesenchymal stem cells markers (ENG) were investigated by real-time RT-PCR.
Gene_expression (expression) of COLIA1 in stem cells
19) Confidence 0.14 Published 2010 Journal Journal of Indian Society of Periodontology Section Body Doc Link PMC2933523 Disease Relevance 0.07 Pain Relevance 0
Interestingly, THY1 is also involved in regulating collagen type I, smooth muscle alpha actin, and TGF-?
Gene_expression (actin) of collagen type I in smooth muscle
20) Confidence 0.14 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2688838 Disease Relevance 0.61 Pain Relevance 0.24

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