INT69216

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Context Info
Confidence 0.49
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 5.84
Pain Relevance 3.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Tgfb1) enzyme binding (Tgfb1) embryo development (Tgfb1)
cytoplasm (Tgfb1) cell proliferation (Tgfb1) extracellular space (Tgfb1)
Anatomy Link Frequency
PSCs 3
platelet 2
neuronal 1
smooth muscle 1
pancreas 1
Tgfb1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 23 100.00 Very High Very High Very High
cytokine 18 100.00 Very High Very High Very High
Spinal cord 18 99.86 Very High Very High Very High
Clonidine 10 99.84 Very High Very High Very High
Sciatic nerve 2 99.44 Very High Very High Very High
addiction 1 98.16 Very High Very High Very High
fibrosis 21 95.96 Very High Very High Very High
Chronic pancreatitis 17 91.04 High High
Neuropeptide 5 88.16 High High
analgesia 1 85.36 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 31 100.00 Very High Very High Very High
Necrosis 2 100.00 Very High Very High Very High
Cancer 2 100.00 Very High Very High Very High
Injury 49 99.64 Very High Very High Very High
Pancreatitis 25 96.24 Very High Very High Very High
Fibrosis 23 95.96 Very High Very High Very High
Fracture Healing 6 93.28 High High
Hypersensitivity 6 92.52 High High
Stress 9 92.00 High High
Primary Sclerosing Cholangitis 6 89.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TGF-beta1 levels were significantly higher in G-CSF-treated rats at the end of the first, second and fourth weeks (p < 0.05).
Positive_regulation (higher) of TGF-beta1
1) Confidence 0.49 Published 2006 Journal Life Sci. Section Abstract Doc Link 17023006 Disease Relevance 0.60 Pain Relevance 0.21
TGFbeta1 protein increased twofold after 24 hours and 48 hours and returned to control values 7 days after induction of pancreatitis, while TGFbeta1-mRNA reached maximal values (3-fold over controls) after 2 days.
Positive_regulation (increased) of TGFbeta1 associated with pancreatitis
2) Confidence 0.37 Published 1999 Journal Hepatogastroenterology Section Abstract Doc Link 10576340 Disease Relevance 0.32 Pain Relevance 0
Rats in the control and thermal injury groups showed similar increases in serum TGF-beta 1 h after injury.
Positive_regulation (increases) of TGF-beta 1 associated with injury
3) Confidence 0.37 Published 2001 Journal Shock Section Abstract Doc Link 11699077 Disease Relevance 0.84 Pain Relevance 0.12
Ellagic acid inhibited the production of reactive oxygen species in pancreatic stellate cells in response to transforming growth factor-beta1 or platelet-derived growth factor.
Positive_regulation (response) of transforming growth factor-beta1 in platelet
4) Confidence 0.33 Published 2009 Journal Dig. Dis. Sci. Section Abstract Doc Link 18651219 Disease Relevance 0.70 Pain Relevance 0.44
CONCLUSION: We conclude that FTY720 prevents pancreatic inflammation and fibrosis by suppressing infiltration of CD4- and CD8-positive T cells and by downregulating induction of interferon and transforming growth factor-beta1 mRNA in the pancreas.


Positive_regulation (induction) of transforming growth factor-beta1 mRNA in pancreas
5) Confidence 0.24 Published 2005 Journal Pancreas Section Body Doc Link 15782091 Disease Relevance 0 Pain Relevance 0
Concentration of activated transforming growth factor-beta1 (TGF-beta1) secreted from PSCs into culture medium was determined by ELISA.
Positive_regulation (activated) of TGF-beta1 in PSCs
6) Confidence 0.21 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.15 Pain Relevance 0.11
Concentration of activated transforming growth factor-beta1 (TGF-beta1) secreted from PSCs into culture medium was determined by ELISA.
Positive_regulation (activated) of transforming growth factor-beta1 in PSCs
7) Confidence 0.21 Published 2004 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 15319186 Disease Relevance 0.15 Pain Relevance 0.11
Parallel to the cell infiltration, an upregulation of messenger RNA-encoding collagen type I and transforming growth factor beta1 could be shown.
Positive_regulation (upregulation) of transforming growth factor beta1
8) Confidence 0.17 Published 1997 Journal Gastroenterology Section Body Doc Link 9136846 Disease Relevance 0.07 Pain Relevance 0
Injuriously high VT ventilation is also capable of rapidly inducing transforming growth factor-beta-1 mRNA, an upstream regulator of collagen synthesis [34].
Positive_regulation (inducing) of transforming growth factor-beta-1 mRNA
9) Confidence 0.17 Published 2007 Journal Crit Care Section Body Doc Link PMC2151905 Disease Relevance 0.17 Pain Relevance 0
Eight of these genes encode neurotrophic/growth factor receptors (Lifr, Crhr1, Gfra2, Gfra1, Ntrk2, Ntrk1, Cntfr, and Adcyap1r1), and 7 encode agents that enhance neuronal survival or axonal regeneration (Hspb1, Ntf5, Tgfa, Zfp91, Artn, Tgfb1, and Mt3).
Positive_regulation (enhance) of Tgfb1 in neuronal
10) Confidence 0.12 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.22 Pain Relevance 0.09
Combination therapy suppressed up-regulation of tumor necrosis factor-alpha, platelet-derived growth factor-receptor beta, and transforming growth factor-beta1 mRNA in the pancreas.
Positive_regulation (up-regulation) of transforming growth factor-beta1 mRNA in platelet associated with necrosis and cancer
11) Confidence 0.11 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15608084 Disease Relevance 0.96 Pain Relevance 0.48
Peri-neural clonidine reduced the increase in tissue content of the proinflammatory cytokines IL-1beta and particularly TNFalpha in sciatic nerve, DRG and spinal cord while increasing concentrations of the anti-inflammatory cytokine TGF-beta1.
Positive_regulation (increasing) of cytokine TGF-beta1 in neural associated with inflammation, sciatic nerve, spinal cord, cytokine and clonidine
12) Confidence 0.08 Published 2003 Journal Pain Section Abstract Doc Link 14499442 Disease Relevance 1.23 Pain Relevance 1.52
Pressure increased the expression levels of alpha-smooth muscle actin, alpha(1)(I)-procollagen, and TGF-beta1 in PSCs.
Positive_regulation (increased) of TGF-beta1 in smooth muscle
13) Confidence 0.06 Published 2007 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 17761838 Disease Relevance 0.37 Pain Relevance 0.22
EGCG also suppressed ethanol-induced p38 mitogen-activated protein (MAP) kinase phosphorylation, alpha-smooth muscle actin production in PSCs and activated transforming growth factor-beta1 secretion into the medium.
Positive_regulation (activated) of transforming growth factor-beta1 in PSCs
14) Confidence 0.05 Published 2006 Journal Eur. J. Clin. Invest. Section Body Doc Link 16436093 Disease Relevance 0.07 Pain Relevance 0

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