INT69217

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 20
Total Number 22
Disease Relevance 7.80
Pain Relevance 4.41

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Notch1) Golgi apparatus (Notch1) plasma membrane (Notch1)
nucleus (Notch1) embryo development (Notch1) cytoplasm (Notch1)
Anatomy Link Frequency
Notch 13
hippocampus 2
neuronal 1
ventricular zone 1
cleavage 1
Notch1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 15 100.00 Very High Very High Very High
opioid receptor 5 100.00 Very High Very High Very High
Chronic pancreatitis 5 99.84 Very High Very High Very High
Hippocampus 31 99.40 Very High Very High Very High
Bile 3 99.12 Very High Very High Very High
cocaine 15 98.76 Very High Very High Very High
alcohol 2 98.52 Very High Very High Very High
cINOD 120 98.08 Very High Very High Very High
fluoxetine 17 96.20 Very High Very High Very High
Kappa opioid receptor 4 95.80 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pancreatitis 5 99.84 Very High Very High Very High
Disease 515 99.20 Very High Very High Very High
Cancer 123 99.04 Very High Very High Very High
Recurrence 4 98.88 Very High Very High Very High
Injury 181 98.48 Very High Very High Very High
Neurodegenerative Disease 33 98.08 Very High Very High Very High
Targeted Disruption 104 94.92 High High
Stress Incontinence 2 94.48 High High
INFLAMMATION 288 94.24 High High
Cognitive Disorder 39 90.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The Notch1 signaling pathway is expressed highly in the hippocampus and could be a target for diverse environmental modulators of adult neurogenesis.
Gene_expression (expressed) of Notch1 in hippocampus associated with hippocampus and neurodegenerative disease
1) Confidence 0.78 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801843 Disease Relevance 0.42 Pain Relevance 0.46
Simultaneously, hippocampal neurogenesis was determined by assessing cell proliferation, survival and differentiation. mRNA and protein expression of Notch1 signaling components (including Jag1, NICD, Hes1 and Hes5) in the hippocampus increased after fluoxetine administration, accompanied by cell proliferation and survival.
Gene_expression (expression) of Notch1 in hippocampus associated with hippocampus, neurodegenerative disease and fluoxetine
2) Confidence 0.78 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801843 Disease Relevance 0.41 Pain Relevance 0.87
Overexpression of Notch1 in rat cortical neurons results in an increase in neuronal branching and an antagonism of neurite extension [100].
Gene_expression (Overexpression) of Notch1 in neuronal
3) Confidence 0.69 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0
This was due to dose-dependent changes in expression at 6 h for several genes that control neurite branching and morphogenesis including Cxcl12, Notch1 and ?
Gene_expression (morphogenesis) of Notch1 in neurite
4) Confidence 0.60 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0 Pain Relevance 0
Immunohistochemistry results showed that Notch1 was expressed mainly in the cytoplasm and ICN mainly in the nucleus.
Gene_expression (expressed) of Notch1 in nucleus
5) Confidence 0.34 Published 2008 Journal Dig. Dis. Sci. Section Body Doc Link 18320325 Disease Relevance 0.15 Pain Relevance 0
The expression of the Notch1, Delta1, ICN, Hes1 and NF-kappaB2 proteins was measured by Western blot.
Gene_expression (expression) of Notch1
6) Confidence 0.34 Published 2008 Journal Dig. Dis. Sci. Section Body Doc Link 18320325 Disease Relevance 0.16 Pain Relevance 0
Notch-2, -3, and -4 mRNA, were overexpressed in chronic pancreatitis specimens.
Gene_expression (overexpressed) of Notch in Notch associated with chronic pancreatitis
7) Confidence 0.30 Published 2006 Journal J. Gastrointest. Surg. Section Abstract Doc Link 17114010 Disease Relevance 0.74 Pain Relevance 0.68
Wnt signaling activates usually the expression of Notch ligands.
Gene_expression (expression) of Notch in Notch
8) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.10 Pain Relevance 0
The pharmacological effects are mediated by the activation of Notch signaling in the NSC, but not by the inhibition of GSK-3b signaling or inositol depletion, currently popular models to explain mood stabilizers' action.
Gene_expression (signaling) of Notch in Notch
9) Confidence 0.23 Published 2008 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19108505 Disease Relevance 0.57 Pain Relevance 0.28
So it is still unclear which E3 ubiquitin ligase monoubiquitinates Notch prior to ?
Gene_expression (monoubiquitinates) of Notch in Notch
10) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
Indeed irradiation activated the Notch pathway, as demonstrated by the expression of the Notch target genes Hey1, and its inhibition by the ?
Gene_expression (expression) of Notch in Notch
11) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2884035 Disease Relevance 0.18 Pain Relevance 0
Similarly to Notch processing, upon neuregulin binding and activation of ErbB4, ?
Gene_expression (processing) of Notch in Notch
12) Confidence 0.04 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.32 Pain Relevance 0.03
Notably, targeting the Notch pathway by using ?
Gene_expression (pathway) of Notch in Notch
13) Confidence 0.04 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 1.39 Pain Relevance 0.27
-secretase, an aspartyl protease that mediates the regulated intramembrane cleavage of multiple cell surface signaling proteins including among others APP, Notch receptors, ErbB4, E- and N-cadherins, p75 and EphB2 (Koo and Kopan, 2004).
Gene_expression (receptors) of Notch in Notch
14) Confidence 0.04 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.57 Pain Relevance 0.23
The transient expression of Notch and yan receptors by P0 RPCs provide examples of known pathways capable of influencing cell fate in response to exogenous signaling.
Gene_expression (expression) of Notch in Notch
15) Confidence 0.04 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0.18 Pain Relevance 0
Similarly, the expression levels of the receptor Notch also dip and rise during the repair period, and in situ hybridization studies reveal that this transcriptional regulation is also occurring within leading wound-edge epidermal cells (Figure 5b-e).
Gene_expression (expression) of Notch in Notch associated with injury
16) Confidence 0.04 Published 2005 Journal Genome Biol Section Body Doc Link PMC549066 Disease Relevance 0.49 Pain Relevance 0
Persistent expression of bHLH HES1, the principal Notch-responsive gene, prevents both migration of neural progenitor cells out of the ventricular zone and expression of neuronal markers [21].
Gene_expression (expression) of Notch in ventricular zone
17) Confidence 0.04 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.83 Pain Relevance 0
On the other hand, the newly synthesized non-peptide selective delta-opioid receptor agonist 2-methyl-4a alpha-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a alpha-octahydro-quinolino(2,3,3,-g)isoquinoline (TAN-67) partially generalized (56.7% cocaine-appropriate responses) to the discriminative stimulus properties of cocaine.
Gene_expression (synthesized) of TAN-67 associated with agonist, opioid receptor and cocaine
18) Confidence 0.04 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9137909 Disease Relevance 0 Pain Relevance 1.47
-secretase cleavage including the type I membrane protein Notch that is critical for development.
Gene_expression (including) of Notch in cleavage
19) Confidence 0.04 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.29 Pain Relevance 0
Further, APP and Notch processing have been shown to occur in spatially distinct sites.
Gene_expression (processing) of Notch in Notch
20) Confidence 0.04 Published 2006 Journal Mol Neurodegener Section Body Doc Link PMC1513131 Disease Relevance 0.12 Pain Relevance 0.06

General Comments

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