INT69222

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 8.19
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Sod1) aging (Sod1) peroxisome (Sod1)
intracellular (Sod1) protein complex (Sod1) cytoplasm (Sod1)
Anatomy Link Frequency
hypothalamus 2
liver 2
lateral 2
spinal cord 1
brain 1
Sod1 (Mus musculus)
Sod1 - G93A (1)
Pain Link Frequency Relevance Heat
Spinal cord 78 100.00 Very High Very High Very High
Paracetamol 10 99.78 Very High Very High Very High
Glutamate 6 98.58 Very High Very High Very High
Inflammation 41 95.84 Very High Very High Very High
medulla 10 93.08 High High
tolerance 29 89.20 High High
nMDA receptor 1 79.20 Quite High
antagonist 1 75.36 Quite High
Central nervous system 4 68.76 Quite High
excitatory amino acid 1 64.84 Quite High
Disease Link Frequency Relevance Heat
Disease 80 99.60 Very High Very High Very High
Targeted Disruption 134 99.28 Very High Very High Very High
Motor Neuron Diseases 91 98.52 Very High Very High Very High
Injury 146 98.36 Very High Very High Very High
Toxicity 37 97.60 Very High Very High Very High
Lifespan 51 97.24 Very High Very High Very High
Insulin Resistance 42 96.64 Very High Very High Very High
Death 81 95.92 Very High Very High Very High
INFLAMMATION 42 95.84 Very High Very High Very High
Parkinson's Disease 12 94.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Catalase and SOD1 (CuZnSOD) are also elevated in the hypothalamus of Ames mice (Hauck and Bartke 2000).
Positive_regulation (elevated) of SOD1 in hypothalamus
1) Confidence 0.61 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.44 Pain Relevance 0
Catalase and SOD1 (CuZnSOD) are also elevated in the hypothalamus of Ames mice (Hauck and Bartke 2000).
Positive_regulation (elevated) of CuZnSOD in hypothalamus
2) Confidence 0.61 Published 2006 Journal Age (Dordr) Section Body Doc Link PMC2464727 Disease Relevance 0.39 Pain Relevance 0
The presence of peroxisomes in mutant SOD1-induced MVISE is a surprise.
Positive_regulation (induced) of SOD1
3) Confidence 0.48 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC169170 Disease Relevance 0.33 Pain Relevance 0
Finally, catalase signal is also detected in both small and large, SOD1-positive vacuoles at early disease stages (Fig. 8).
Positive_regulation (vacuoles) of SOD1 associated with disease
4) Confidence 0.48 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC169170 Disease Relevance 0.10 Pain Relevance 0.04
The APAP treatment activated liver c-jun N-terminal kinase (JNK) in the WT and GPX1(-/-) mice, but not in the SOD1(-/-) mice.
Neg (not) Positive_regulation (activated) of SOD1 in liver associated with paracetamol
5) Confidence 0.48 Published 2006 Journal Exp. Biol. Med. (Maywood) Section Abstract Doc Link 17138759 Disease Relevance 0.51 Pain Relevance 0.69
This neuroprotective effect appears to be associated with increased ATP production in isolated spinal cord SOD1-G93A mitochondria when DHB is used as a substrate (Scheme 1, see Figure 5).
Positive_regulation (increased) of SOD1 (G93A) in spinal cord associated with spinal cord
6) Confidence 0.47 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1488864 Disease Relevance 0.70 Pain Relevance 0.12
It is possible that mitochondrial vacuolation represents an accelerated form of mitochondrial damage caused by high levels of mutant SOD1 accumulation.
Positive_regulation (accumulation) of SOD1
7) Confidence 0.45 Published 2003 Journal BMC Neurosci Section Body Doc Link PMC169170 Disease Relevance 0.52 Pain Relevance 0.05
To determine whether the effect of SOD1 on hepatic insulin resistance is different from that of SOD2 (mitochondrial isoform), we investigated the effect of overexpression of SOD2 in the liver of db/db mice using the same strategy as was used for SOD1 treatment in the present study.
Positive_regulation (used) of SOD1 in liver associated with insulin resistance
8) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.24 Pain Relevance 0.04
In contrast, exogenous glycine and glutamate decreased the inhibitory effect of Zn2+ in the brain but dramatically increased the inhibitory effect of Zn2+ in the spinal cord.
Positive_regulation (increased) of Zn2 in brain associated with glutamate and spinal cord
9) Confidence 0.40 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9137921 Disease Relevance 0 Pain Relevance 0.58
The recombinant adenovirus AdSOD1 encoding human SOD1 was kindly provided by Dr.
Positive_regulation (provided) of AdSOD1
10) Confidence 0.35 Published 2008 Journal Diabetes Section Body Doc Link PMC2494675 Disease Relevance 0.25 Pain Relevance 0.04
UA2 treatment results in increased levels of SOD1, and decreased accumulation of protein carbonyls and nitrated proteins, in the wound tissue
Positive_regulation (increased) of SOD1 associated with injury
11) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2850366 Disease Relevance 1.45 Pain Relevance 0.05
UA2 treatment results in increased levels of SOD1, and decreased accumulation of protein carbonyls and nitrated proteins, in the wound tissue
Positive_regulation (levels) of SOD1 associated with injury
12) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2850366 Disease Relevance 1.40 Pain Relevance 0.05
9) and transgenic mice (BL6/SJL) carrying the normal allele for SOD1 gene (n?
Positive_regulation (allele) of SOD1 associated with targeted disruption
13) Confidence 0.31 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2429976 Disease Relevance 0.36 Pain Relevance 0.03
Mutations of the SOD1 gene encoding CuZn SOD are found in patients with familial amyotrophic lateral sclerosis (FALS), a progressive and fatal paralytic disease that is caused by the death of motor neurons in cortex, brainstem and spinal cord.
Positive_regulation (Mutations) of SOD1 gene in lateral associated with medulla, disease, death, motor neuron diseases and spinal cord
14) Confidence 0.27 Published 1998 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 9728338 Disease Relevance 0.62 Pain Relevance 0.09
Mutations of the SOD1 gene encoding CuZn SOD are found in patients with familial amyotrophic lateral sclerosis (FALS), a progressive and fatal paralytic disease that is caused by the death of motor neurons in cortex, brainstem and spinal cord.
Positive_regulation (Mutations) of CuZn SOD in lateral associated with medulla, disease, death, motor neuron diseases and spinal cord
15) Confidence 0.27 Published 1998 Journal J. Inherit. Metab. Dis. Section Abstract Doc Link 9728338 Disease Relevance 0.63 Pain Relevance 0.09
The increases in SOD activities are likely caused by the induction of protein expression, since there was a 37% increase in MnSOD and a 23% increase in CuZnSOD expression levels (Figure 3B).
Positive_regulation (increase) of CuZnSOD
16) Confidence 0.25 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2668769 Disease Relevance 0.26 Pain Relevance 0

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