INT69229

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Context Info
Confidence 0.76
First Reported 1997
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 7
Disease Relevance 8.19
Pain Relevance 6.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ngf, Bdnf) signal transduction (Ngf) extracellular space (Ngf)
aging (Ngf) cytoplasmic membrane-bounded vesicle (Bdnf) molecular_function (Ngf)
Anatomy Link Frequency
Nerve 4
neurons 4
DRG 4
spinal nerve 2
Ngf (Rattus norvegicus)
Bdnf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 52 100.00 Very High Very High Very High
Nerve growth factor 33 100.00 Very High Very High Very High
Inflammation 23 100.00 Very High Very High Very High
ganglionectomy 2 98.08 Very High Very High Very High
Hyperalgesia 3 95.04 Very High Very High Very High
Eae 16 94.00 High High
Spinal cord 2 90.88 High High
allodynia 4 89.60 High High
Sciatica 3 85.84 High High
Neuropeptide 2 84.88 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 52 100.00 Very High Very High Very High
INFLAMMATION 20 100.00 Very High Very High Very High
Hyperalgesia 4 95.04 Very High Very High Very High
Injury 16 94.00 High High
Hypersensitivity 1 91.84 High High
Neuropathic Pain 9 89.60 High High
Nerve Root Compression 1 85.84 High High
Pain 5 75.00 Quite High
Nervous System Injury 3 64.24 Quite High
Wallerian Degeneration 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest that peripheral inflammation induces an increased expression of BDNF mRNA which is mediated by NGF in DRG.
NGF Positive_regulation (mediated) of Gene_expression (expression) of BDNF mRNA in DRG associated with dorsal root ganglion, nerve growth factor and inflammation
1) Confidence 0.76 Published 1997 Journal Brain Res. Section Abstract Doc Link 9138740 Disease Relevance 0.96 Pain Relevance 0.71
Nerve growth factor (NGF) from inflammatory tissue is thought to induce expression of BDNF.
Nerve growth factor Positive_regulation (induce) of Gene_expression (expression) of BDNF in Nerve associated with inflammation and nerve growth factor
2) Confidence 0.69 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17764660 Disease Relevance 0.70 Pain Relevance 0.56
Nerve growth factor (NGF) from inflammatory tissue is thought to induce expression of BDNF.
NGF Positive_regulation (induce) of Gene_expression (expression) of BDNF in Nerve associated with inflammation and nerve growth factor
3) Confidence 0.69 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17764660 Disease Relevance 0.69 Pain Relevance 0.56
Furthermore, L5 ventral rhizotomy up-regulated nerve growth factor (NGF) protein in small to medium diameter neurons in the L5 DRG and also in ED-1-positive cells in the L5 spinal nerve, suggesting that NGF synthesized in the degenerative fibers is transported to the L5 DRG and increases BDNF synthesis.
NGF Positive_regulation (increases) of Gene_expression (synthesis) of BDNF in spinal nerve associated with dorsal root ganglion and nerve growth factor
4) Confidence 0.43 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15191811 Disease Relevance 1.36 Pain Relevance 1.14
On the other hand, the nerve growth factor (NGF)-induced increase in BDNF expression in small-to-medium-diameter neurons was reversed by SB203580, whereas the anti-NGF-induced increase in NPY in medium-sized and large-sized neurons was partially blocked by U0126.
NGF Positive_regulation (increase) of Gene_expression (expression) of BDNF in neurons associated with nerve growth factor
5) Confidence 0.39 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579142 Disease Relevance 1.49 Pain Relevance 1.20
On the other hand, the nerve growth factor (NGF)-induced increase in BDNF expression in small-to-medium-diameter neurons was reversed by SB203580, whereas the anti-NGF-induced increase in NPY in medium-sized and large-sized neurons was partially blocked by U0126.
nerve growth factor Positive_regulation (increase) of Gene_expression (expression) of BDNF in neurons associated with nerve growth factor
6) Confidence 0.39 Published 2004 Journal Eur. J. Neurosci. Section Abstract Doc Link 15579142 Disease Relevance 1.50 Pain Relevance 1.21
Therefore, we suggest that after inflammation near the cell body, NGF synthesized within the nerve root and DRG induces BDNF expression through trkA receptors and intracellular ERK-MAPK.
NGF Positive_regulation (induces) of Gene_expression (expression) of BDNF in DRG associated with dorsal root ganglion, nerve growth factor and inflammation
7) Confidence 0.04 Published 2004 Journal Neuroscience Section Abstract Doc Link 15207334 Disease Relevance 1.49 Pain Relevance 1.29

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