INT69252

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Context Info
Confidence 0.09
First Reported 1996
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) extracellular region (Cpe)
Golgi apparatus (Cpe)
Anatomy Link Frequency
striatum 2
Cpe (Mus musculus)
Pain Link Frequency Relevance Heat
Enkephalin 6 100.00 Very High Very High Very High
Dopamine 23 99.00 Very High Very High Very High
substance P 5 97.08 Very High Very High Very High
projection neuron 3 91.76 High High
Ventral tegmentum 1 63.44 Quite High
Substantia nigra 2 61.40 Quite High
antagonist 2 20.88 Low Low
Nucleus accumbens 9 5.00 Very Low Very Low Very Low
cocaine 5 5.00 Very Low Very Low Very Low
GABAergic 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Stress 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of enkephalin mRNA in the striatum is increased in the mutant mice, but not that of dynorphin and substance P.
Neg (not) Positive_regulation (increased) of Transcription (expression) of enkephalin in striatum
1) Confidence 0.09 Published 1996 Journal Genes Cells Section Body Doc Link 9140068 Disease Relevance 0 Pain Relevance 0
Moreover, the loss of DA innervation caused by 6-hydroxydopamine (6-OHDA) increased the expression of mRNAs encoding the D2R and enkephalin selectively in striatopallidal MSNs, whereas mRNAs encoding the D1R and substance P were only decreased in striatonigral MSNs (Gerfen et al., 1990).
Positive_regulation (increased) of Transcription (expression) of enkephalin associated with dopamine, enkephalin and substance p
2) Confidence 0.02 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0 Pain Relevance 0.58

General Comments

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