INT6926

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Context Info
Confidence 0.39
First Reported 1980
Last Reported 2010
Negated 9
Speculated 8
Reported most in Abstract
Documents 72
Total Number 80
Disease Relevance 55.79
Pain Relevance 65.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
neurons 10
PAG 8
dorsal 3
PAG 3
brain 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 921 100.00 Very High Very High Very High
Pain 316 100.00 Very High Very High Very High
Morphine 234 100.00 Very High Very High Very High
Periaqueductal grey 177 100.00 Very High Very High Very High
Opioid 77 100.00 Very High Very High Very High
analgesia 75 100.00 Very High Very High Very High
withdrawal 63 100.00 Very High Very High Very High
GABAergic 55 100.00 Very High Very High Very High
gABA 53 100.00 Very High Very High Very High
narcan 27 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 1442 100.00 Very High Very High Very High
Pain 355 100.00 Very High Very High Very High
Nociception 192 100.00 Very High Very High Very High
Diabetes Mellitus 18 100.00 Very High Very High Very High
Pressure Volume 2 Under Development 6 100.00 Very High Very High Very High
Anxiety Disorder 73 99.98 Very High Very High Very High
Lordosis 5 99.84 Very High Very High Very High
Low Back Pain 3 99.66 Very High Very High Very High
INFLAMMATION 177 99.50 Very High Very High Very High
Neuropathic Pain 104 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We suggest that pain stimulus has somehow impaired the anxiolytic effect of the dPAG bilateral lesion.
Regulation (effect) of dPAG associated with pain and anxiety disorder
1) Confidence 0.39 Published 2009 Journal Behav. Brain Res. Section Abstract Doc Link 19410607 Disease Relevance 1.16 Pain Relevance 0.56
Some studies have indicated that alterations in the levels of cerebral 5-hydroxytryptamine (5-HT) mediate or modulate the analgesic effect of PAG stimulation.
Regulation (effect) of PAG in PAG associated with analgesic and urological neuroanatomy
2) Confidence 0.32 Published 2004 Journal Brain Res. Section Abstract Doc Link 15120594 Disease Relevance 0.64 Pain Relevance 0.34
Our study has also investigated the role of PAG mGluR(7) on thermoceptive threshold and PAG glutamate and GABA release.
Spec (investigated) Regulation (role) of PAG associated with gaba, glutamate and central grey
3) Confidence 0.32 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17507496 Disease Relevance 0.62 Pain Relevance 0.75
To determine whether nocuous stimuli affect basal glutamatergic synaptic transmission in the PAG, we measured the AMPA receptor-mediated mEPSCs.
Spec (whether) Regulation (affect) of PAG associated with central grey
4) Confidence 0.30 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.95 Pain Relevance 0.48
The present study has demonstrated that functional 5-HT1A, 5-HT1B and 5-HT1D receptors are present on GABAergic nerve terminals within the PAG.
Regulation (present) of PAG in nerve associated with periaqueductal grey and gabaergic
5) Confidence 0.30 Published 2008 Journal Mol Pain Section Body Doc Link PMC2588575 Disease Relevance 0.37 Pain Relevance 1.09
METHODS: This hypothesis was tested by measuring the behavioral and electrophysiological effects of administering dopamine agonists and antagonists into the ventrolateral PAG (vPAG).
Regulation (ventrolateral) of vPAG
6) Confidence 0.27 Published 2009 Journal Psychopharmacology (Berl.) Section Body Doc Link 19225762 Disease Relevance 0.09 Pain Relevance 0
Less dense projections target the PAG, the locus coeruleus and pericoerulear areas, and dorsal and ventral reticular nuclei of the caudal medulla.
Regulation (target) of PAG in dorsal associated with medulla, locus ceruleus and central grey
7) Confidence 0.24 Published 2006 Journal J. Chem. Neuroanat. Section Abstract Doc Link 17049433 Disease Relevance 0.77 Pain Relevance 1.20
This report is to alert clinicians to the possible role of the PAG in impaired opioid responsiveness in patients with terminal malignancy, as well as the possibility that pain-like signs (e.g., tachycardia, tachypnea, vocalization, facial grimacing) may indicate an aversive reaction rather than pain in non-verbal patients.
Spec (possible) Regulation (role) of PAG associated with pain, heart rate under development, malignant neoplastic disease, opioid and central grey
8) Confidence 0.23 Published 1995 Journal Pain Section Abstract Doc Link 8628594 Disease Relevance 1.31 Pain Relevance 1.14
The suppressive effect of PAG and NRM stimulation on the reflexes and NST reflex interneurons could be reduced by the intravenous administration of naloxone.
Regulation (effect) of PAG in interneurons associated with raphe magnus, narcan and urological neuroanatomy
9) Confidence 0.23 Published 1981 Journal Brain Res. Section Abstract Doc Link 6266582 Disease Relevance 0.65 Pain Relevance 0.78
Results indicate that inflammatory painful stimuli have no effect on the basal excitatory synaptic transmission in the PAG.


Neg (no) Regulation (effect) of PAG associated with pain, inflammation and central grey
10) Confidence 0.22 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.18 Pain Relevance 0.69
These verifications are a necessary first step because now these transgenic mice can be used in electrophysiology or anatomical tract tracing studies to identify the role of the GABA vlPAG neurons in the REM sleep circuit.
Regulation (role) of vlPAG in neurons associated with targeted disruption and gaba
11) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2709920 Disease Relevance 0.55 Pain Relevance 0.17
In these morphine tolerant-dependent mice, the greater changes were found for RGS9-2 in the thalamus (>500%) and PAG (>200%).
Regulation (changes) of PAG in thalamus associated with urological neuroanatomy, thalamus and morphine
12) Confidence 0.21 Published 2005 Journal Neuropsychopharmacology Section Abstract Doc Link 15199376 Disease Relevance 0.39 Pain Relevance 1.26
The pituitary content of beta-ELIR was higher in DBA/2, while the values in the periaqueductal grey (PAG) and in the amygdala were higher in C57BL/6 mice.
Regulation (values) of PAG in amygdala associated with periaqueductal grey and amygdala
13) Confidence 0.21 Published 1988 Journal Brain Res. Section Abstract Doc Link 3401713 Disease Relevance 0.88 Pain Relevance 0.74
RESULTS: The main findings were: (1) intervention modulated PAG activity to painful stimuli more in responders than in nonresponders, (2) change in PAG activity from the whole patient population correlated with change in pressure pain threshold, and (3) a network known to regulate affective qualities of the pain experience was (subsignificantly) engaged more in responders than in nonresponders.
Regulation (change) of PAG
14) Confidence 0.21 Published 2007 Journal Clin J Pain Section Body Doc Link 17515743 Disease Relevance 0.19 Pain Relevance 0
These results are discussed in terms of the possible contribution these forebrain areas have in regulating the PAG with regard to its functions as a visceral, nociceptive, and cognitive integrator.
Regulation (regulating) of PAG in forebrain associated with nociception, cognitive disorder and central grey
15) Confidence 0.21 Published 1982 Journal J. Comp. Neurol. Section Abstract Doc Link 7085925 Disease Relevance 0.73 Pain Relevance 0.33
To see which of the forebrain areas directly influence the PAG, small injections of horseradish peroxidase were made into the various regions of monkey, cat, and rat PAG.
Regulation (influence) of PAG in forebrain associated with central grey
16) Confidence 0.21 Published 1982 Journal J. Comp. Neurol. Section Abstract Doc Link 7085925 Disease Relevance 0.60 Pain Relevance 0.52
RESULTS: The main findings were: (1) intervention modulated PAG activity to painful stimuli more in responders than in nonresponders, (2) change in PAG activity from the whole patient population correlated with change in pressure pain threshold, and (3) a network known to regulate affective qualities of the pain experience was (subsignificantly) engaged more in responders than in nonresponders.
Regulation (modulated) of PAG
17) Confidence 0.21 Published 2007 Journal Clin J Pain Section Body Doc Link 17515743 Disease Relevance 0.20 Pain Relevance 0
The results suggest that the ventrolateral PAG may activate a complex pontobulbar neuronal assembly including neurons in the intermediate subdivision of the pontobulbar reticular formation, serotonin- and tyrosine-hydroxylase-immunoreactive and nonimmunoreactive neurons in the RVM and pontine noradrenergic nuclei.
Regulation (ventrolateral) of PAG in PAG associated with periaqueductal grey, serotonin and rostral ventromedial medulla
18) Confidence 0.21 Published 2001 Journal Eur. J. Neurosci. Section Abstract Doc Link 11703456 Disease Relevance 0.71 Pain Relevance 0.86
The effect of diabetes on periaqueductal gray matter (PAG) stimulation-produced analgesia (SPA) was examined in rats.
Spec (examined) Regulation (effect) of PAG in gray matter associated with diabetes mellitus, urological neuroanatomy, central grey and analgesia
19) Confidence 0.20 Published 1992 Journal Neurosci. Lett. Section Abstract Doc Link 1407710 Disease Relevance 1.21 Pain Relevance 0.98
Finally, the same rats were anesthetized with pentobarbital sodium and microelectrode recordings made from single sacral dorsal horn neurons responsive to the same noxious heat stimuli delivered to the tail to assess effects of PAG and LRF stimulation. 3.
Regulation (effects) of PAG in tail associated with central grey and dorsal horn neuron
20) Confidence 0.19 Published 1995 Journal J. Neurophysiol. Section Abstract Doc Link 7666131 Disease Relevance 0.51 Pain Relevance 0.74

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