INT69264

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 23
Speculated 6
Reported most in Body
Documents 207
Total Number 213
Disease Relevance 179.41
Pain Relevance 8.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (KIT) extracellular space (KIT) plasma membrane (KIT)
nucleus (KIT) cytoplasm (KIT)
Anatomy Link Frequency
stem cell 17
smooth muscle 10
platelet 5
bone marrow 5
hematopoietic cells 4
KIT (Homo sapiens)
Pain Link Frequency Relevance Heat
Central nervous system 49 98.44 Very High Very High Very High
Bile 12 97.28 Very High Very High Very High
Inflammation 181 97.04 Very High Very High Very High
ischemia 36 96.56 Very High Very High Very High
Nerve growth factor 2 96.36 Very High Very High Very High
cytokine 143 96.08 Very High Very High Very High
headache 30 95.76 Very High Very High Very High
Pain 109 95.36 Very High Very High Very High
fibrosis 32 95.20 Very High Very High Very High
abdominal pain 94 95.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 4818 100.00 Very High Very High Very High
Metastasis 533 100.00 Very High Very High Very High
Lymphatic System Cancer 101 100.00 Very High Very High Very High
Bacterial Respiratory Disease 15 100.00 Very High Very High Very High
Gastrointestinal Stromal Tumor 1980 99.98 Very High Very High Very High
Skin Cancer 36 99.98 Very High Very High Very High
Diffuse Large B-cell Lymphoma 29 99.98 Very High Very High Very High
Sarcoma 295 99.96 Very High Very High Very High
Glioma 41 99.94 Very High Very High Very High
Stomach Cancer 1393 99.84 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Most GISTs (>90%) express CD117, the c-kit proto-oncogene protein that is a transmembrane receptor for the stem cell growth factor, and 70% to 80% express CD34, the human progenitor cell antigen; less often, these tumors stain positive for actin and desmin [9].
Gene_expression (express) of CD117 in stem cell associated with cancer
1) Confidence 0.78 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2664807 Disease Relevance 1.10 Pain Relevance 0
Immunohistochemical analysis revealed expression of C-kit (strongly positive), moderately positive stain for SMA, while markers for focal S-100 and CD 34 were negative (Figure 5).
Gene_expression (expression) of C-kit
2) Confidence 0.78 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2664807 Disease Relevance 1.32 Pain Relevance 0
In our study, none of the studied 38 cases displayed a CD117 expression immunohistochemically.
Gene_expression (expression) of CD117
3) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.02 Pain Relevance 0
An additional agent is associated with the expression and inhibition of CD117 (c-kit), and has been effectively used in various neoplasms such as hematological malignancies and gastrointestinal stromal tumors (GIST).
Gene_expression (expression) of CD117 associated with cancer, hematologic neoplasms and gastrointestinal stromal tumor
4) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.62 Pain Relevance 0.05
Surprisingly, the CD117 expression in gastric carcinomas was not clearly evident although it has been investigated in numerous tumors, such as germ cell or melanocytic malignancies.
Gene_expression (expression) of CD117 in germ cell associated with cancer and stomach cancer
5) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 0.87 Pain Relevance 0
An additional agent is associated with the expression and inhibition of CD117 (c-kit), and has been effectively used in various neoplasms such as hematological malignancies and gastrointestinal stromal tumors (GIST).
Gene_expression (expression) of kit associated with cancer, hematologic neoplasms and gastrointestinal stromal tumor
6) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.62 Pain Relevance 0.05
Expression of CD117, c-kit and the stem cell factor (SCF) receptor
Gene_expression (Expression) of CD117 in stem cell
7) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.07 Pain Relevance 0
This statement holds true, even if more sensitive methods like fluorescent in situ hybridization (FISH) may detect a CD117 expression in gastric carcinoma tumor cells without corresponding IHC results.
Gene_expression (expression) of CD117 associated with cancer and stomach cancer
8) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.03 Pain Relevance 0
In the literature, only one study examining the expression of CD117 in gastric carcinomas exists to our knowledge until now [18].
Gene_expression (expression) of CD117 associated with stomach cancer
9) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.06 Pain Relevance 0
Singular CD117 expression or in combination with that of SCF is noted in several hematopoetic tumors including mast cell leukemia, acute myelogenous leukemia, and other myeloproliferative disorders [10].
Gene_expression (expression) of CD117 in mast cell associated with myeloproliferative disorder, cancer, acute myeloid leukemia and mast cell leukemia
10) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.88 Pain Relevance 0
Most tumor cells in Hodgkin's disease including mononuclear and Reed-Sternberg cells express c-kit [10].
Gene_expression (express) of kit associated with cancer and disease
11) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.98 Pain Relevance 0
Thus, these inhibitors could be potentially considered as a new target for therapeutic regimes in gastric carcinomas; however, only if a significant CD117 expression could be demonstrated, i.e., by use of IHC.
Gene_expression (expression) of CD117 associated with stomach cancer
12) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.15 Pain Relevance 0
Immunohistochemically, expression of CD117 also has been demonstrated in leiomyosarcomas of the uterus [39], and has been identified in about 50% of small cell or large cell neuroendocrine lung carcinomas [2].
Gene_expression (expression) of CD117 in uterus associated with leiomyosarcoma and lung cancer
13) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.66 Pain Relevance 0
Over-expression of CD117 is almost always seen in GIST [42].
Gene_expression (expression) of CD117 associated with gastrointestinal stromal tumor
14) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.66 Pain Relevance 0
Expression of CD117, c-kit and the stem cell factor (SCF) receptor
Gene_expression (Expression) of kit in stem cell
15) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.07 Pain Relevance 0
Interestingly, normal breast epithelial cells abundantly express c-kit, whereas a loss of c-kit expression has been reported in 80–90% of breast cancer cases [37].
Gene_expression (expression) of kit in epithelial cells associated with breast cancer
16) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 1.77 Pain Relevance 0.03
We could only evaluate one article that describes an over expression of the CD117 gene in gastric carcinoma cell cultures [18].
Gene_expression (expression) of CD117 gene associated with stomach cancer
17) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 0.97 Pain Relevance 0
Expression of CD117 has been noted in a subset of angiosarcoma cases, a phenomenon that has been compared to the action of an oncofetal protein or its anti-apoptotic effect [9].
Gene_expression (Expression) of CD117 associated with hemangiosarcoma and apoptosis
18) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 0.93 Pain Relevance 0
In fact, the c-kit expression in acute leukemia can be considered as an indicator of myeloid origin of tumor cells [10] as it is rarely expressed in lymphoid blast cells.
Gene_expression (expression) of kit in blast cells associated with leukemia and cancer
19) Confidence 0.77 Published 2006 Journal Diagn Pathol Section Body Doc Link PMC1475889 Disease Relevance 2.09 Pain Relevance 0
GISTs are characterized by the expression of the cell surface marker CD117, which is found in 95–100% of GISTs [3].
Gene_expression (expression) of CD117
20) Confidence 0.77 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2661077 Disease Relevance 0.58 Pain Relevance 0.06

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