INT6928

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Context Info
Confidence 0.26
First Reported 1989
Last Reported 1992
Negated 1
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 1.06
Pain Relevance 2.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tfpi) extracellular region (Tfpi)
Anatomy Link Frequency
EPI 2
plasma 1
SPNs 1
Tfpi (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central grey 10 100.00 Very High Very High Very High
analgesia 1 100.00 Very High Very High Very High
medulla 3 99.56 Very High Very High Very High
narcan 8 99.54 Very High Very High Very High
Morphine 10 99.04 Very High Very High Very High
antagonist 6 96.68 Very High Very High Very High
cva 2 95.80 Very High Very High Very High
withdrawal 5 95.64 Very High Very High Very High
anesthesia 3 95.00 High High
Catecholamine 3 93.76 High High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 10 100.00 Very High Very High Very High
Hemorrhage 2 95.80 Very High Very High Very High
Volume Depletion And Dehydration 1 77.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is concluded that Epi acting on alpha 1- and alpha 2-adrenergic receptors depolarizes and hyperpolarizes the rat SPNs by decreasing or increasing membrane conductances to potassium ions.
Regulation (acting) of Epi in SPNs
1) Confidence 0.26 Published 1989 Journal Brain Res. Section Abstract Doc Link 2790446 Disease Relevance 0 Pain Relevance 0.24
After removal of adrenal glands from morphine-dependent rats, naloxone injection produced no change in the BP or plasma Epi.
Neg (no) Regulation (change) of Epi in plasma associated with narcan and morphine
2) Confidence 0.24 Published 1990 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2395117 Disease Relevance 0 Pain Relevance 1.35
These findings indicate that: (1) hypophysial portal EPI plasma concentration is highly dependent on an adrenal source; (2) hypothalamic EPI is not released into portal circulation in response to acute hemorrhage, and (3) anesthesia markedly influences catecholamines plasma levels.
Regulation (dependent) of EPI in EPI associated with anesthesia, catecholamine and cva
3) Confidence 0.24 Published 1990 Journal Neuroendocrinology Section Abstract Doc Link 2124657 Disease Relevance 0.27 Pain Relevance 0.40
As this part of PAG contains many neurons that project to the ventral medulla, it is possible that EPI modulates the PAG-medullary functions such as analgesia, autonomic regulation, defense reactions, and sexual behaviors.
Regulation (regulation) of EPI in EPI associated with medulla, central grey and analgesia
4) Confidence 0.19 Published 1992 Journal Brain Res. Bull. Section Abstract Doc Link 1335350 Disease Relevance 0.79 Pain Relevance 0.62

General Comments

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