INT69282

Context Info Confidence 0.15 First Reported 1997 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 4 Total Number 4 Disease Relevance 1.43 Pain Relevance 0.41

peptidase activity (PHEX) protein modification process (PHEX) Golgi apparatus (PHEX) endoplasmic reticulum (PHEX) plasma membrane (PHEX) cell-cell signaling (PHEX)

Anatomy Link Frequency plasma 1 erythrocyte 1 Hyp12 1 PHEX (Homo sapiens)

Pain Link Frequency Relevance Heat corticosteroid 23 94.88 ischemia 2 89.00 medulla 3 88.64 Inflammation 5 85.40 Neuropeptide 1 83.28 Potency 2 79.52 Enkephalin 1 79.20 Pain 2 68.92 Action potential 7 5.00 agonist 5 5.00

Disease Link Frequency Relevance Heat Rickets 1 99.40 Adhesions 45 95.32 Cv Unclassified Under Development 2 89.00 Motor Neuron Diseases 3 88.04 Guillain-barre Syndrome 5 87.12 Chronic Progressive External Ophthalmoplegia 1 84.60 Mitochondrial Disorders 1 82.72 Poisoning 1 81.72 Gastroenteritis 2 80.52 Syndrome 3 80.12

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Rapid, temporary improvement may be achieved for myasthenic crises and exacerbations with plasma exchange (PEX) or intravenous immunoglobulin (IVIg).

PEX Binding (exacerbations) of in plasma

1) Confidence 0.15 Published 2007 Journal Orphanet J Rare Dis Section Abstract Doc Link PMC2211463 Disease Relevance 1.01 Pain Relevance 0.18

The role of HYP in GpVI-dependent binding was investigated by modifying III-30 with HYP?

HYP Binding (modifying) of

2) Confidence 0.06 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.18 Pain Relevance 0

Two other mammalian gene products exhibit strong homology with NEP: the erythrocyte cell-surface antigen, KELL; and the putative product of the PEX gene, which has been associated with X-linked hypophosphatemic rickets.

PEX gene Binding (associated) of in erythrocyte associated with rickets

3) Confidence 0.05 Published 1997 Journal FASEB J. Section Abstract Doc Link 9141502 Disease Relevance 0.18 Pain Relevance 0.12

In particular, noncovalent interactions between Val3 and Hyp12 are likely to be involved in maintaining a stable conformation.

Hyp12 Binding (interactions) of in Hyp12

4) Confidence 0.04 Published 2005 Journal Biopolymers Section Abstract Doc Link 15931669 Disease Relevance 0.07 Pain Relevance 0.11

General Comments

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