INT69283

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Context Info
Confidence 0.75
First Reported 1997
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 25
Total Number 30
Disease Relevance 7.81
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (PHEX) protein modification process (PHEX) Golgi apparatus (PHEX)
endoplasmic reticulum (PHEX) plasma membrane (PHEX) cell-cell signaling (PHEX)
Anatomy Link Frequency
platelets 5
erythrocyte 1
lumen 1
cleavage 1
parathyroid 1
PHEX (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 109 91.76 High High
Inflammation 132 89.44 High High
Neuropeptide 3 83.88 Quite High
Opioid 6 81.92 Quite High
abdominal pain 6 81.08 Quite High
Enkephalin 2 79.92 Quite High
Central nervous system 4 74.24 Quite High
corticosteroid 52 71.44 Quite High
antagonist 39 19.08 Low Low
rheumatoid arthritis 20 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myasthenia Gravis 336 98.46 Very High Very High Very High
Rickets 3 98.32 Very High Very High Very High
Hypophosphatemia 5 98.00 Very High Very High Very High
Sepsis 4 97.72 Very High Very High Very High
Obesity 64 94.96 High High
Adhesions 495 94.28 High High
Volume Depletion And Dehydration 3 92.60 High High
Osteoporosis 65 92.12 High High
Neuropathy 2 90.04 High High
INFLAMMATION 146 89.44 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, membranes expressing rPhex-WT, rPhex-3'M, and the empty vector hydrolyzed parathyroid hormone-(1-34), indicating the lack of Phex-specific cleavage of parathyroid hormone.
Gene_expression (expressing) of Phex in parathyroid
1) Confidence 0.75 Published 2001 Journal Am. J. Physiol. Endocrinol. Metab. Section Abstract Doc Link 11551862 Disease Relevance 0.39 Pain Relevance 0.08
hyp/hyp, in which a hypomorphic mutation at the PPAR-?
Gene_expression (/) of hyp
2) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.52 Pain Relevance 0
hyp/hyp, in which a hypomorphic mutation at the PPAR-?
Gene_expression (mutation) of hyp
3) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.53 Pain Relevance 0
hyp/hyp, in which a hypomorphic mutation at the PPAR-?
Gene_expression (at) of hyp
4) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.53 Pain Relevance 0
hyp/hyp, in which a hypomorphic mutation at the PPAR-?
Gene_expression (/) of hyp
5) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.52 Pain Relevance 0
hyp/hyp, in which a hypomorphic mutation at the PPAR-?
Gene_expression (at) of hyp
6) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.53 Pain Relevance 0
hyp/hyp, in which a hypomorphic mutation at the PPAR-?
Gene_expression (mutation) of hyp
7) Confidence 0.65 Published 2010 Journal PPAR Research Section Body Doc Link PMC2896849 Disease Relevance 0.53 Pain Relevance 0
The data were expressed as specific activity (cpm hyp or pro ?
Gene_expression (pro) of hyp
8) Confidence 0.65 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1876619 Disease Relevance 0 Pain Relevance 0
The data were expressed as specific activity (cpm hyp or pro ?
Gene_expression (expressed) of hyp
9) Confidence 0.65 Published 2007 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC1876619 Disease Relevance 0 Pain Relevance 0
This is followed by endopeptidases and/or exopeptidases mediated cleavage of the oligopeptides which, in turn, produces a multiplicity of short peptides differing by one or more amino acid residues.
Gene_expression (followed) of endopeptidases in cleavage
10) Confidence 0.41 Published 2004 Journal J. Dairy Res. Section Abstract Doc Link 15068070 Disease Relevance 0 Pain Relevance 0.08
In MG, IVIg may provide short-term improvement in strength for MG exacerbations and crises, for surgical preparation in patients who are poor PEX candidates because of vascular access issues, and in patients with septicemia.
Gene_expression (candidates) of PEX associated with myasthenia gravis and sepsis
11) Confidence 0.28 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 1.34 Pain Relevance 0.04
Although many patients have large antecubital veins that may be accessed serially for PEX procedures, some patients require placement of large bore dual lumen central venous catheters.
Gene_expression (procedures) of PEX in lumen
12) Confidence 0.28 Published 2007 Journal Orphanet J Rare Dis Section Body Doc Link PMC2211463 Disease Relevance 0.98 Pain Relevance 0.15
Two C. intestinalis (Cin3 and Cin4) genes are seen to cluster with the PHEX group of peptidases indicating a potential recent, gene duplication in Ciona (Figure 2 V).
Gene_expression (group) of PHEX
13) Confidence 0.16 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0 Pain Relevance 0
PHEX is unusual for an M13 peptidase in that it appears to have a preference for acidic residues at its S1' site [13].
Gene_expression (unusual) of PHEX
14) Confidence 0.14 Published 2008 Journal BMC Evol Biol Section Body Doc Link PMC2259306 Disease Relevance 0.39 Pain Relevance 0
Its specific sequence is GAOGLRGGAGPOGPEGGKGAAGPOGPOGP, containing 3 HYP residues within OGP/GPO motifs (bold type highlights OGP/GPO-containing portions of the peptide).
Gene_expression (residues) of HYP
15) Confidence 0.10 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.09 Pain Relevance 0
Other peptides containing 4 HYP residues within OGP/GPO motifs are III-12, III-22, III-40, and III-57.
Gene_expression (residues) of HYP
16) Confidence 0.10 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.08 Pain Relevance 0
For human platelets, single HYP?
Gene_expression (single) of HYP in platelets
17) Confidence 0.10 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.15 Pain Relevance 0
Platelet binding to III-30b was largely unaffected, making it an excellent GpVI substrate with only 2 HYP residues within 2 GPOGP motifs spaced 5 triplets apart, a feature it shares with III-26, which did not bind platelets.
Gene_expression (residues) of HYP in platelets
18) Confidence 0.10 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.13 Pain Relevance 0
It is striking that III-30b-XL, which contains 2 HYP residues in OGP/GPO motifs, activated murine platelets, whereas III-01a-XL, which contains 6 such HYP residues, did not.
Gene_expression (residues) of HYP in platelets
19) Confidence 0.10 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0 Pain Relevance 0.05
PRO and p8 with HYP?
Gene_expression (PRO) of HYP
20) Confidence 0.10 Published 2008 Journal Blood Section Body Doc Link PMC2602586 Disease Relevance 0.17 Pain Relevance 0

General Comments

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