INT69289

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 44
Total Number 48
Disease Relevance 13.28
Pain Relevance 6.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cftr) transport (Cftr) ATPase activity (Cftr)
enzyme binding (Cftr) protein complex (Cftr) transmembrane transport (Cftr)
Anatomy Link Frequency
Caco-2 8
nasal 2
intestinal cells 1
epithelial cells 1
lungs 1
Cftr (Mus musculus)
Pain Link Frequency Relevance Heat
fibrosis 1061 100.00 Very High Very High Very High
cINOD 6 99.98 Very High Very High Very High
COX-2 inhibitor 1 99.64 Very High Very High Very High
substance P 18 99.00 Very High Very High Very High
Chronic pancreatitis 29 98.42 Very High Very High Very High
aspirin 22 96.08 Very High Very High Very High
antagonist 5 93.96 High High
agonist 5 93.68 High High
adenocard 5 92.72 High High
Inflammation 147 88.00 High High
Disease Link Frequency Relevance Heat
Fibrosis 4 100.00 Very High Very High Very High
Disease 89 99.92 Very High Very High Very High
Infection 179 99.84 Very High Very High Very High
Cystic Fibrosis 1057 99.76 Very High Very High Very High
Stress 35 98.60 Very High Very High Very High
Pancreatitis 41 98.42 Very High Very High Very High
Disorder Of Lipid Metabolism 348 98.00 Very High Very High Very High
Diabetes Mellitus 32 97.84 Very High Very High Very High
Dyslipidemia /

Combined Dyslipidemia

29 95.96 Very High Very High Very High
Targeted Disruption 55 95.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, CFTR depletion may hamper the potential interactions with other proteins, including transporters, receptors and signalling proteins.
Negative_regulation (depletion) of CFTR
1) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.12 Pain Relevance 0
In a subset of experiments, differentiated Caco-2/15 cells were treated for 3 days with 20 µM of the highly selective CFTR inhibitor, CFTR-inh172 (Sigma, St-Louis, MO).
Negative_regulation (inhibitor) of CFTR in Caco-2
2) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.14 Pain Relevance 0
In contrast, treatment with the CFTR inhibitor, CFTR inh-172, led to an increase in all desaturase indexes (data not shown), which is concordant with a previous study performed in CF patients [33].
Negative_regulation (inhibitor) of CFTR associated with fibrosis
3) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.15 Pain Relevance 0.05
Even if blocking chloride conductance was previously shown to disturb the FA profile of airway epithelial cells [22], reduction in the cellular content of CFTR appears to exert additional influences.
Negative_regulation (reduction) of CFTR in epithelial cells
4) Confidence 0.57 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.14 Pain Relevance 0
Treatment with NSAIDs reduced CFTR transcripts, and decreased cAMP-stimulated anion fluxes, an index of CFTR function.
Negative_regulation (reduced) of CFTR associated with cinod
5) Confidence 0.56 Published 1999 Journal Mediators Inflamm Section Abstract Doc Link PMC1781806 Disease Relevance 0.91 Pain Relevance 0.78
In a subset of experiments, differentiated Caco-2/15 cells were treated for 3 days with 20 µM of the highly selective CFTR inhibitor, CFTR-inh172 (Sigma, St-Louis, MO).
Negative_regulation (inhibitor) of CFTR-inh172 in Caco-2
6) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.14 Pain Relevance 0
Modifications in the FA profile were reproduced to a lesser extent when CFTR was pharmacologically blocked with the selective inhibitor, CFTR-inh 172 suggesting a direct involvement of CFTR per se.
Negative_regulation (blocked) of CFTR
7) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.16 Pain Relevance 0.04
Infection of Caco-2/15 cells with lentivirus carrying CFTR-shRNAi caused a reduction in CFTR gene (61%) and protein (57%) expression when compared to non-infected cells (Figure 1).
Negative_regulation (reduction) of CFTR gene in Caco-2 associated with infection
8) Confidence 0.50 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.10 Pain Relevance 0
In patients with two CFTR mutations, extrapancreatic clinical findings and nasal bioelectric responses suggested reduced residual CFTR protein function.
Negative_regulation (reduced) of CFTR in nasal
9) Confidence 0.44 Published 2002 Journal J. Investig. Med. Section Abstract Doc Link 12227654 Disease Relevance 0.83 Pain Relevance 0.51
Since the discovery of the gene responsible for CF disease, a number of CFTR gene-targeted mouse models, such as CFTR -/- mice [9], were generated to investigate the pathophysiology of this disease.
Negative_regulation (number) of CFTR associated with fibrosis and disease
10) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 1.39 Pain Relevance 0.39
Secretion was also stimulated 25-fold by basolateral application of SP, and this response was strongly inhibited by the CFTR inhibitor CFTR(inh)172.
Negative_regulation (inhibitor) of CFTR associated with substance p
11) Confidence 0.43 Published 2008 Journal Pflugers Arch. Section Abstract Doc Link 18509672 Disease Relevance 0.25 Pain Relevance 0.44
Secretion was also stimulated 25-fold by basolateral application of SP, and this response was strongly inhibited by the CFTR inhibitor CFTR(inh)172.
Negative_regulation (inhibitor) of CFTR associated with substance p
12) Confidence 0.43 Published 2008 Journal Pflugers Arch. Section Abstract Doc Link 18509672 Disease Relevance 0.25 Pain Relevance 0.44
Basal HCO3- secretion was diminished significantly (P < 0.01) in CFTR(-/-)vs. normal CFTR(+/+) mice (2.8 +/- 0.5 vs. 5.3 +/- 0.4 micromol x cm(-1) x h(-1)).
Negative_regulation (diminished) of CFTR
13) Confidence 0.43 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9142920 Disease Relevance 0.14 Pain Relevance 0.24
The absence of CFTR or its F508del mutation (known to promote CFTR degradation) may increase cPLA2?
Negative_regulation (absence) of CFTR
14) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC2873258 Disease Relevance 0.47 Pain Relevance 0.15
However, additional studies are clearly needed to clarify the impact of CFTR depletion on the FA oxidation status especially in view of a recent report suggesting an impairment of ?
Negative_regulation (depletion) of CFTR
15) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.18 Pain Relevance 0.09
In order to maintain continuous CFTR inhibition, culture medium, including CFTR-inh172 was replenished every 24 h.
Negative_regulation (replenished) of CFTR-inh172
16) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.15 Pain Relevance 0
We used the shRNAi experimental approach to generate a model of Caco-2/15 cells deficient in CFTR.
Negative_regulation (deficient) of CFTR in Caco-2
17) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.10 Pain Relevance 0
We next examine the possibility that de novo lipogenesis could be stimulated in a state of CFTR depletion.
Negative_regulation (depletion) of CFTR
18) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.12 Pain Relevance 0
In order to maintain continuous CFTR inhibition, culture medium, including CFTR-inh172 was replenished every 24 h.
Negative_regulation (inhibition) of CFTR
19) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.14 Pain Relevance 0
In conclusion, our data bring novel and exciting insights on the effects of CFTR depletion, at a level seen in heterozygous subjects and even individuals carrying other CFTR mutations, on intestinal FA homeostasis.
Negative_regulation (depletion) of CFTR
20) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864762 Disease Relevance 0.06 Pain Relevance 0.03

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