INT69298

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Context Info
Confidence 0.36
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.78
Pain Relevance 1.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
macrophages 1
neutrophil 1
seb (Mus musculus)
Pain Link Frequency Relevance Heat
qutenza 2 99.44 Very High Very High Very High
Morphine 1 98.92 Very High Very High Very High
MU agonist 3 98.16 Very High Very High Very High
antagonist 10 93.16 High High
Opioid 5 92.72 High High
substance P 2 91.28 High High
opiate 2 79.36 Quite High
narcan 4 77.92 Quite High
Neuropeptide 4 76.48 Quite High
opioid receptor 2 75.36 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 55 94.96 High High
Shock 2 94.64 High High
Lymphatic System Cancer 95 92.40 High High
Sepsis 4 77.40 Quite High
Cancer 11 75.00 Quite High
Necrosis 4 75.00 Quite High
Bacterial Infection 2 75.00 Quite High
Pressure Volume 2 Under Development 1 70.32 Quite High
Death 7 66.04 Quite High
Injury 1 63.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naltrexone significantly inhibited the production of TNF-alpha induced by LPS, but not SEB in vivo.
Negative_regulation (inhibited) of SEB
1) Confidence 0.36 Published 2004 Journal Brain Behav. Immun. Section Abstract Doc Link 15265541 Disease Relevance 0.91 Pain Relevance 0.66
However, suppression of the T cell response to SEB presented by resting macrophages required 100 times the concentration of U50,488H.
Negative_regulation (suppression) of SEB in macrophages
2) Confidence 0.36 Published 1997 Journal J. Neuroimmunol. Section Abstract Doc Link 9143250 Disease Relevance 0 Pain Relevance 0.63
Additionally, T5 or T8 cells were inoculated in the footpad and 3–6 days later mice received SEI, SEB or PBS.
Negative_regulation (received) of SEB
3) Confidence 0.32 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3008744 Disease Relevance 1.86 Pain Relevance 0
Capsaicin pretreatment significantly reduced SEA- and SEB-induced neutrophil influx in bronchoalveolar lavage fluid, but this treatment was more effective to reduce SEA responses.
Negative_regulation (reduced) of SEB in neutrophil associated with qutenza
4) Confidence 0.07 Published 2009 Journal Eur. J. Pharmacol. Section Abstract Doc Link 19375418 Disease Relevance 0 Pain Relevance 0.40

General Comments

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