INT69302

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Context Info
Confidence 0.21
First Reported 1997
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 0.99
Pain Relevance 0.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde1b) nucleolus (Pde1b) nucleus (Pde1b)
cytoplasm (Pde1b)
Anatomy Link Frequency
macrophage 1
Pde1b (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuritis 12 99.86 Very High Very High Very High
Peripheral nervous system 3 84.60 Quite High
cytokine 5 60.44 Quite High
Inflammation 77 50.16 Quite High
dexamethasone 1 50.00 Quite Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
adenocard 4 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Experimental Autoimmune Neuritis 12 99.86 Very High Very High Very High
Immunization 2 74.16 Quite High
INFLAMMATION 89 50.16 Quite High
Pulmonary Disease 62 35.84 Quite Low
Vomiting 10 17.92 Low Low
Targeted Disruption 4 14.96 Low Low
Disease 13 5.00 Very Low Very Low Very Low
Hypertension 10 5.00 Very Low Very Low Very Low
Increased Venous Pressure Under Development 8 5.00 Very Low Very Low Very Low
Nicotine Addiction 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Selective upregulation of PDE1B2 has been described on monocyte to macrophage differentiation (Bender et al 2005) and appears to have a role in determining the phenotype of the macrophage (Bender and Beavo 2006).
Positive_regulation (upregulation) of PDE1B2 in macrophage
1) Confidence 0.21 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
The PDE1 subfamily is as diverse as the PDE4 subfamily and is encoded by three genes giving the isoforms PDE1A, PDE1B, and PDE1C.
Positive_regulation (giving) of PDE1B
2) Confidence 0.15 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650605 Disease Relevance 0 Pain Relevance 0
RESULTS: Dexamethasone induced ulceration was associated with changes in the phospholipid fatty acid profile, levels of lipid peroxidation products, nitric oxide and activity of anti-oxidant enzymes.
Positive_regulation (changes) of anti-oxidant
3) Confidence 0.10 Published 2000 Journal Prostaglandins Leukot. Essent. Fatty Acids Section Body Doc Link 10780873 Disease Relevance 0 Pain Relevance 0
Also, in IL-10-treated EAN rats, upregulated anti-P2 IgG1 and downregulated IgG2a were observed.
Positive_regulation (upregulated) of anti-P2 IgG1 associated with neuritis
4) Confidence 0.01 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143372 Disease Relevance 0.99 Pain Relevance 0.97

General Comments

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