INT69303

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Context Info
Confidence 0.68
First Reported 1997
Last Reported 2010
Negated 1
Speculated 2
Reported most in Abstract
Documents 27
Total Number 29
Disease Relevance 20.01
Pain Relevance 14.80

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il4) extracellular region (Il4)
Anatomy Link Frequency
plasma 6
mononuclear cell 6
T cell 4
macrophage 2
lymph node 2
Il4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 220 100.00 Very High Very High Very High
Inflammation 198 100.00 Very High Very High Very High
Morphine 18 99.98 Very High Very High Very High
Migraine 9 99.96 Very High Very High Very High
dorsal root ganglion 92 99.84 Very High Very High Very High
Sciatic nerve 2 99.84 Very High Very High Very High
fluoxetine 10 99.68 Very High Very High Very High
Root ganglion neuron 4 99.56 Very High Very High Very High
Thermal hyperalgesia 49 99.44 Very High Very High Very High
Neuritis 33 99.30 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 214 100.00 Very High Very High Very High
Necrosis 16 100.00 Very High Very High Very High
Cancer 16 100.00 Very High Very High Very High
Cold Sores 88 99.98 Very High Very High Very High
Headache 6 99.96 Very High Very High Very High
Ganglion Cysts 97 99.84 Very High Very High Very High
Hyperalgesia 57 99.44 Very High Very High Very High
Experimental Autoimmune Neuritis 33 99.30 Very High Very High Very High
Apoptosis 17 99.16 Very High Very High Very High
Injury 33 98.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In DBTC-treated rats, adenovirus-mediated transfer of the IL-4 gene modified the pattern of infiltrating inflammatory cells in the pancreas.
Positive_regulation (transfer) of Gene_expression (transfer) of IL-4 in pancreas
1) Confidence 0.68 Published 2005 Journal Scand. J. Gastroenterol. Section Body Doc Link 16165721 Disease Relevance 0 Pain Relevance 0
Pretreatment with H2-receptor antagonist, ranitidine produced a 15.7% reduction in the mucosal damage caused by indomethacin, 29.5% decrease in epithelial cell apoptosis and a 19.6% reduction in ET-1, while the expression of IL-4 increased by 10.8% and that of cNOS showed a 2-fold increase.
Positive_regulation (increased) of Gene_expression (expression) of IL-4 in epithelial cell associated with antagonist and apoptosis
2) Confidence 0.61 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.66 Pain Relevance 0.10
Vector-mediated IL-4 expression also reduced thermal hyperalgesia.
Positive_regulation (mediated) of Gene_expression (expression) of IL-4 associated with thermal hyperalgesia
3) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 0.54 Pain Relevance 0.72
In the experiments that are the subject of the current report, we have demonstrated that transgene-mediated expression of IL-4 in DRG effectively reduces nocifensive behaviors and blocks expression of IL-1?
Positive_regulation (mediated) of Gene_expression (expression) of IL-4 associated with dorsal root ganglion
4) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.31 Pain Relevance 1.23
Vector-mediated IL-4 production did not affect normal sensory function.
Positive_regulation (mediated) of Gene_expression (production) of IL-4
5) Confidence 0.56 Published 2006 Journal Mol Pain Section Body Doc Link PMC1395302 Disease Relevance 1.00 Pain Relevance 0.77
Adenovirus-mediated gene transfer of interleukin-4 into pancreatic stellate cells promotes interleukin-10 expression.
Positive_regulation (transfer) of Gene_expression (transfer) of interleukin-4 in stellate cells
6) Confidence 0.50 Published 2006 Journal J. Cell. Mol. Med. Section Title Doc Link 17125592 Disease Relevance 0.65 Pain Relevance 0.28
In this study, we investigated mucosal expression of ET-1, interleukin-4 (IL-4), and the activity of constitutive nitric oxide synthase (cNOS) during indomethacin-induced gastric mucosal injury, and evaluated the effect of antiulcer agents on this process.
Spec (investigated) Positive_regulation (mucosal) of Spec (investigated) Gene_expression (expression) of interleukin-4 associated with injury
7) Confidence 0.44 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.42 Pain Relevance 0.10
In this study, we investigated mucosal expression of ET-1, interleukin-4 (IL-4), and the activity of constitutive nitric oxide synthase (cNOS) during indomethacin-induced gastric mucosal injury, and evaluated the effect of antiulcer agents on this process.
Spec (investigated) Positive_regulation (mucosal) of Spec (investigated) Gene_expression (expression) of IL-4 associated with injury
8) Confidence 0.44 Published 1999 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 10424717 Disease Relevance 0.42 Pain Relevance 0.10
Fluoxetine administration elevated the levels of IL-4 at 1, 2 and 3 weeks; and of IL-2, at 2 and 3 weeks.
Positive_regulation (elevated) of Gene_expression (levels) of IL-4 associated with fluoxetine
9) Confidence 0.40 Published 2009 Journal Int. Immunopharmacol. Section Abstract Doc Link 19189865 Disease Relevance 0.17 Pain Relevance 1.04
The positive reference drug, indomethacin at a dosage of 10mg/kg, demonstrated inhibitory potency in both rat models, but it could not augment the production of IL-4, indicating JCICM-6 and indomethacin might possess different pharmacological properties and molecular mechanisms although both have anti-inflammatory and analgesic effects in rats.
Neg (not) Positive_regulation (augment) of Gene_expression (production) of IL-4 associated with inflammation, analgesic and potency
10) Confidence 0.38 Published 2008 Journal Phytomedicine Section Abstract Doc Link 18424100 Disease Relevance 0.75 Pain Relevance 0.59
HSV-mediated expression of interleukin-4 in dorsal root ganglion neurons reduces neuropathic pain

Background

Positive_regulation (mediated) of Gene_expression (expression) of interleukin-4 in dorsal root ganglion associated with ganglion cysts, cold sores, neuropathic pain and root ganglion neuron
11) Confidence 0.38 Published 2006 Journal Mol Pain Section Title Doc Link PMC1395302 Disease Relevance 1.48 Pain Relevance 1.03
The infiltration of CD4(+) and CD8(+) T cells and the sera level of IFN-gamma and TNF-alpha were decreased significantly (P<0.05), whereas IL-4 level in the supernatant of cultured lymphocytes was increased (P<0.05).
Positive_regulation (increased) of Gene_expression (level) of IL-4 in lymphocytes
12) Confidence 0.23 Published 2007 Journal Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Section Body Doc Link 17210108 Disease Relevance 0.07 Pain Relevance 0
To study the potential role of cytokines in context with cytokine autoantibodies (Aabs) in EAN, we used in situ hybridization to detect mRNA expression of interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, IL-4, IL-10, and transforming growth factor (TGF)-beta in lymph node mononuclear cell (MNC) and in sciatic nerve sections, as well as ELISA for detection of their autoantibodies in sera and cerebrospinal fluid (CSF) over the course of EAN.
Positive_regulation (detect) of Gene_expression (expression) of IL-4 in mononuclear cell associated with necrosis, cancer, sciatic nerve, neuritis and cytokine
13) Confidence 0.20 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15530887 Disease Relevance 1.13 Pain Relevance 1.02
(P < 0.05) and increased the levels of IL-4 (P < 0.05).
Positive_regulation (increased) of Gene_expression (levels) of IL-4
14) Confidence 0.19 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3004822 Disease Relevance 0.71 Pain Relevance 0.06
This clinical effect was associated with dose-dependent down-regulated production of IFN-gamma and the chemokines macrophage inflammatory protein-1 alpha (MIP-1 alpha, MIP-2 and monocyte chemotactic protein-1(MCP-1) as well as up-regulated IL-4 production in sciatic nerve sections from Rolipram-treated EAN rats at maximum of clinical EAN, i.e. on day 14 p.i..
Positive_regulation (up-regulated) of Gene_expression (production) of IL-4 in macrophage associated with chemokine, inflammation, sciatic nerve and neuritis
15) Confidence 0.16 Published 2000 Journal Autoimmunity Section Abstract Doc Link 11078155 Disease Relevance 1.33 Pain Relevance 1.10
levels of IL-4 were also found increased at 24 hours after ERCP than those of
Positive_regulation (increased) of Gene_expression (levels) of IL-4
16) Confidence 0.11 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 0.50 Pain Relevance 0.09
According to our results, neither IL-2 levels nor IL-2/IL-4 ratios
Positive_regulation (According) of Gene_expression (ratios) of IL-4
17) Confidence 0.08 Published 2008 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2486352 Disease Relevance 0.96 Pain Relevance 0.37
After treatment with sumatriptan, 10 patients showed a subsequent decrease in IL-10 and an increase in both IL-4 and IL-5 plasma levels.
Positive_regulation (increase) of Gene_expression (levels) of IL-4 in plasma associated with sumatriptan
18) Confidence 0.07 Published 2001 Journal Headache Section Abstract Doc Link 11576199 Disease Relevance 0.24 Pain Relevance 0.50
P2 protein-reactive IFN-gamma, TNF-alpha, IL-1 beta, and IL-6 mRNA-expressing lymph node cells were also downregulated in IL-10-treated compared to control EAN rats at Day 14 and 26 pi, while P2-reactive IL-4 mRNA-expressing cells were upregulated throughout treatment.
Positive_regulation (upregulated) of Gene_expression (expressing) of IL-4 in lymph node associated with neuritis
19) Confidence 0.07 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143372 Disease Relevance 1.12 Pain Relevance 1.11
Cytokines and migraine: increase of IL-5 and IL-4 plasma levels.
Positive_regulation (increase) of Gene_expression (levels) of IL-4 in plasma associated with migraine and cytokine
20) Confidence 0.06 Published 1998 Journal Headache Section Title Doc Link 9664752 Disease Relevance 0.37 Pain Relevance 0.62

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