INT69304

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Context Info
Confidence 0.59
First Reported 1997
Last Reported 2010
Negated 3
Speculated 1
Reported most in Body
Documents 47
Total Number 49
Disease Relevance 36.88
Pain Relevance 19.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il10) extracellular region (Il10) intracellular (Il10)
Anatomy Link Frequency
plasma 4
blood 2
macrophages 1
lymph node 1
lymphocytes 1
Il10 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 490 100.00 Very High Very High Very High
Inflammation 366 100.00 Very High Very High Very High
antidepressant 14 99.70 Very High Very High Very High
Eae 150 99.44 Very High Very High Very High
Neuritis 25 99.16 Very High Very High Very High
cINOD 22 98.94 Very High Very High Very High
Serotonin 4 98.94 Very High Very High Very High
Neuropathic pain 60 98.84 Very High Very High Very High
Inflammatory response 38 98.72 Very High Very High Very High
corticosteroid 8 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 414 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 23 100.00 Very High Very High Very High
Chorioamnionitis 66 99.96 Very High Very High Very High
Obesity 50 99.84 Very High Very High Very High
Injury 306 99.82 Very High Very High Very High
Shock 5 99.72 Very High Very High Very High
Cirrhosis 10 99.70 Very High Very High Very High
Ulcers 22 99.48 Very High Very High Very High
Apoptosis 37 99.42 Very High Very High Very High
Heart Rate Under Development 23 99.28 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We observed a decrease in the serum IL-10 and nerve conduction velocity and increase in the serum nitrate, malondialdehyde (MDA) and TNF-alpha levels in the 4 and 6h I/R groups in biochemical and electrophysiological evaluations.
Negative_regulation (decrease) of IL-10 in nerve
1) Confidence 0.59 Published 2010 Journal J. Neurosci. Methods Section Abstract Doc Link 20026113 Disease Relevance 1.23 Pain Relevance 0.43
A subsequent sharp decline of IL-10 protein below the baseline level of the naïve DRG was found in L4-L5 DRG of both sides, but more so in the ipsilateral ones.
Negative_regulation (decline) of IL-10
2) Confidence 0.57 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.74 Pain Relevance 0.51
A transient decrease of IL-10 protein level in DRG following CCI may explain why various treatments increasing local IL-10 concentration may be beneficial in neuropathic pain states [30,50].
Negative_regulation (decrease) of IL-10 associated with eae and neuropathic pain
3) Confidence 0.57 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2828436 Disease Relevance 0.81 Pain Relevance 0.94
Recruitment of epineurial IL-10 immunoreactive macrophages as well as the recovery of injury-induced depletion of endoneurial IL-10-IR was enhanced by thalidomide treatment.
Negative_regulation (depletion) of IL-10-IR in macrophages associated with injury
4) Confidence 0.56 Published 2000 Journal Pain Section Abstract Doc Link 11068114 Disease Relevance 0.89 Pain Relevance 0.77
The levels of TNF-alpha, IL-1 and IL-2 in the serum of AA rats were increased, whereas the level of IL-10 was decreased.
Negative_regulation (decreased) of IL-10
5) Confidence 0.44 Published 2009 Journal Acta Pharmacol. Sin. Section Body Doc Link 19169271 Disease Relevance 0.20 Pain Relevance 0
IL-10 levels declined bilaterally even below baseline level in both cervical and lumbar DRG 7 days from CCI and normalized after 14 days.
Negative_regulation (declined) of IL-10 associated with eae
6) Confidence 0.42 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2828436 Disease Relevance 0.95 Pain Relevance 0.70
In contrast to TNF-alpha, IL-10 levels were significantly (p < 0.05) decreased in all three drug groups.
Negative_regulation (decreased) of IL-10
7) Confidence 0.40 Published 2006 Journal Clin. Exp. Rheumatol. Section Body Doc Link 16956424 Disease Relevance 0 Pain Relevance 0
Deactivation of SN, which by itself failed to affect CIP, completely reversed the beneficial effects of i.c.v. administration of LPS on CIP and reduced plasma leptin and IL-10 concentrations.
Negative_regulation (reduced) of IL-10 in plasma
8) Confidence 0.37 Published 2002 Journal Med. Sci. Monit. Section Body Doc Link 11951059 Disease Relevance 0.13 Pain Relevance 0
Moreover, previous study demonstrated level of IL-10 was reduced in patients with CHF [11].
Negative_regulation (reduced) of IL-10 associated with heart rate under development
9) Confidence 0.34 Published 2009 Journal Mediators of Inflammation Section Body Doc Link PMC2768010 Disease Relevance 1.79 Pain Relevance 0.46
In chorioamnionitis, diminished IL-10 levels may provide an ineffective counter regulatory response to elevated maternal prostaglandin stimulated by the pro-inflammatory cytokines IL-1, IL-6 and TNF.
Negative_regulation (diminished) of IL-10 associated with inflammation, chorioamnionitis and cytokine
10) Confidence 0.34 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 1.07 Pain Relevance 0.34
was unchanged, IL-6 was decreased (p < 0.05) in the recovered group when compared with all groups, and IL-10 protein levels were reduced (p < 0.05) in the recovered group when compared with the control.
Negative_regulation (reduced) of IL-10 protein
11) Confidence 0.33 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2959201 Disease Relevance 0.28 Pain Relevance 0.08
In contrast to ASA, the treatment with NO-ASA failed to influence both, the ulcer healing and GBF at ulcer margin and significantly attenuated the plasma levels of IL-1beta, TNF-alpha and IL-10 as compared to those recorded in ASA- or rofecoxib-treated animals.
Neg (failed) Negative_regulation (attenuated) of IL-10 in plasma associated with ulcers
12) Confidence 0.29 Published 2004 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15613743 Disease Relevance 2.00 Pain Relevance 0.14
The IL-10 serum concentration was also increased significantly in the MCAO/R groups and decreased marginally after BC administration.
Negative_regulation (decreased) of IL-10 associated with middle cerebral artery infarction
13) Confidence 0.28 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2895699 Disease Relevance 1.53 Pain Relevance 0.64
There was a notable decrease in levels of IL-4 (63.8 ± 11.1 pg/mL vs. 105.9 ± 24.2 pg/mL) and IL-10 (462.4 ± 31.2 pg/mL vs. 979.5 ± 150.3 pg/mL).
Negative_regulation (decrease) of IL-10
14) Confidence 0.28 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC3004822 Disease Relevance 0.49 Pain Relevance 0.14
and decrease in the levels of IL-4 and IL-10.
Negative_regulation (decrease) of IL-10
15) Confidence 0.28 Published 2010 Journal Cardiovasc Diabetol Section Abstract Doc Link PMC3004822 Disease Relevance 0.80 Pain Relevance 0.13
in rats plasma were also significantly enhanced, and level of IL-10 was obviously lowered through ethanol treatment.
Negative_regulation (lowered) of IL-10 in plasma
16) Confidence 0.25 Published 2010 Journal Pharmacognosy Magazine Section Abstract Doc Link PMC2900062 Disease Relevance 0.41 Pain Relevance 0.13
The mutant also decreased the activation-induced release of TNF and IFN-gamma from mesenteric T cells and the IL-10 concentration in colonic tissue, while increasing the activation-induced secretion of IL-10 in splenocytes and mesenteric lymphocytes and the baseline IL-10 release of splenocytes.
Negative_regulation (decreased) of IL-10 in lymphocytes
17) Confidence 0.24 Published 2008 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 18312544 Disease Relevance 0.67 Pain Relevance 0.64
Anti-apoptotic genes including Akt3, Bcl2, Il10 and Xiap [31-36] were unaffected.
Neg (unaffected) Negative_regulation (unaffected) of Il10 associated with apoptosis
18) Confidence 0.21 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC3001741 Disease Relevance 0.67 Pain Relevance 0.04
and IL-13 are shown in Figure 5; GLP-2 and GLP-2-MMB treatment resulted in a significant decrease in mucosal IL-10, but no change in IL-13 levels.
Negative_regulation (decrease) of IL-10
19) Confidence 0.18 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2952794 Disease Relevance 0.67 Pain Relevance 0.31
Both anesthetics reduced the interleukin IL-6/IL-10 ratio in response to LPS when compared with LPS alone.
Negative_regulation (reduced) of IL-10
20) Confidence 0.18 Published 2008 Journal J Trauma Section Body Doc Link 18580536 Disease Relevance 0 Pain Relevance 0

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