INT69306

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Context Info
Confidence 0.57
First Reported 1997
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 28
Total Number 29
Disease Relevance 24.81
Pain Relevance 9.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (TH1L) nucleus (TH1L)
Anatomy Link Frequency
macrophages 4
Th1 cell 4
lymphocyte 3
T cells 2
fibroblasts 1
TH1L (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 477 100.00 Very High Very High Very High
Inflammation 788 99.96 Very High Very High Very High
rheumatoid arthritis 657 99.82 Very High Very High Very High
Neuritis 21 99.16 Very High Very High Very High
Multiple sclerosis 35 98.24 Very High Very High Very High
tolerance 44 96.32 Very High Very High Very High
corticosteroid 10 93.40 High High
chemokine 3 90.20 High High
Inflammatory response 25 83.44 Quite High
Demyelination 4 83.28 Quite High
Disease Link Frequency Relevance Heat
Hypersensitivity 66 100.00 Very High Very High Very High
Genetic Predisposition To Disease 5 100.00 Very High Very High Very High
INFLAMMATION 794 99.96 Very High Very High Very High
Peritonitis 1 99.90 Very High Very High Very High
Rheumatoid Arthritis 664 99.82 Very High Very High Very High
Disease 306 99.60 Very High Very High Very High
Aging 2 99.36 Very High Very High Very High
Experimental Autoimmune Neuritis 18 99.16 Very High Very High Very High
Malabsorption Syndromes 12 98.86 Very High Very High Very High
Demyelinating Disease 42 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hyporesponsiveness of T cells, downregulation of Th1 cell responses (INF-gamma), but increased levels of specific IgG1 isotypes document that nasal administration of rrIL-4 was systemically immune effective.
Negative_regulation (downregulation) of Th1 in nasal
1) Confidence 0.57 Published 1999 Journal J. Autoimmun. Section Abstract Doc Link 10047428 Disease Relevance 1.01 Pain Relevance 0.72
Effects of low-dosage simvastatin on rheumatoid arthritis through reduction of Th1/Th2 and CD4/CD8 ratios.
Negative_regulation (reduction) of Th1 associated with inflammation and rheumatoid arthritis
2) Confidence 0.57 Published 2007 Journal Mod Rheumatol Section Title Doc Link 17929126 Disease Relevance 0.77 Pain Relevance 0.40
Immunological assessment in peripheral blood revealed that the Th1/Th2 and CD4/CD8 ratios were significantly reduced by simvastatin.
Negative_regulation (reduced) of Th1 in blood
3) Confidence 0.57 Published 2007 Journal Mod Rheumatol Section Abstract Doc Link 17929126 Disease Relevance 0.51 Pain Relevance 0.22
The mechanism of action for GA is unique among the drugs at present approved for MS treatment: rather than having any specific and direct anti-inflammatory effect through inhibition of Th-1 lymphocytes, GA promotes a shift to an anti-inflammatory environment by activating Th-2 lymphocytes (Young 2002).
Negative_regulation (inhibition) of Th-1 in lymphocytes associated with multiple sclerosis and inflammation
4) Confidence 0.42 Published 2008 Journal Patient preference and adherence Section Body Doc Link PMC2770403 Disease Relevance 1.38 Pain Relevance 0.41
Thus, we hypothesize that negative regulators of Tc1/Th1 T cell function may accumulate or be up-regulated in the vaccination site microenvironment over time.
Negative_regulation (regulators) of Th1 in Th1 T cell
5) Confidence 0.37 Published 2010 Journal J Transl Med Section Body Doc Link PMC2936306 Disease Relevance 0.28 Pain Relevance 0.07
Indeed, a reduction of the systemic Th1 functions with aging in normal individuals has been reported [32].
Negative_regulation (reduction) of Th1 associated with aging
6) Confidence 0.32 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400411 Disease Relevance 0.81 Pain Relevance 0.54
There is evidence of a short-lived (less than 1 day) greater shift towards Th2 function, mainly through suppression of the Th1 lymphocyte population, after open surgery than after closed procedures.
Negative_regulation (suppression) of Th1 in lymphocyte
7) Confidence 0.30 Published 2001 Journal Surg. Oncol. Clin. N. Am. Section Abstract Doc Link 11685934 Disease Relevance 0.06 Pain Relevance 0.03
Further, studies have also shown that severe AE or CE cases exhibit poor lymphocyte responses both in vivo and in vitro with the Th1 immune response being strongly suppressed in patients with advanced disease [12,14].
Negative_regulation (suppressed) of Th1 in lymphocyte associated with disease
8) Confidence 0.28 Published 2009 Journal Parasit Vectors Section Body Doc Link PMC2776006 Disease Relevance 1.48 Pain Relevance 0
Although the mechanisms underlying this phenomenon remain unclear, a marked decrease in Th1-mediated immunity during pregnancy has been firmly established.
Negative_regulation (decrease) of Th1
9) Confidence 0.27 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 1.31 Pain Relevance 0.38
Failure to downregulate activated Th1 cells at disease initiation might thereby allow Th1 inflammation to persist and evolve into chronic inflammation, characterized by the continuous activation of T cells, macrophages, fibroblasts, and osteoclasts and, subsequently, the destruction of tissue.
Negative_regulation (downregulate) of Th1 in fibroblasts associated with inflammation and disease
10) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 1.29 Pain Relevance 0.50
Thus, at the onset of the disease, those patients cannot generate immunoregulatory Th2 cells that might downregulate ongoing Th1-mediated inflammation.
Spec (might) Negative_regulation (downregulate) of Th1 in Th2 cells associated with inflammation and disease
11) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 1.32 Pain Relevance 0.55
The characteristic Th1 immune reaction, delayed-type hypersensitivity, is diminished during pregnancy.
Negative_regulation (diminished) of Th1 associated with hypersensitivity
12) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 1.26 Pain Relevance 0.43
Like Tr1 cells, Th3 cells can downregulate Th1 inflammation, and it is speculated that both subsets play a role in maintaining peripheral tolerance [53].
Negative_regulation (downregulate) of Th1 in Tr1 cells associated with inflammation and tolerance
13) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.62 Pain Relevance 0.34
Together, the data suggest that the anti-inflammatory effect of a number of current treatment modalities in RA is characterized by an inhibition of Th1 cell activation and effector cell generation, and by favoring Th2 differentiation, thereby shifting the Th1/Th2 balance toward Th2.
Negative_regulation (shifting) of Th1 in Th1 cell associated with inflammation and rheumatoid arthritis
14) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.44 Pain Relevance 0.36
Together, the data suggest that the anti-inflammatory effect of a number of current treatment modalities in RA is characterized by an inhibition of Th1 cell activation and effector cell generation, and by favoring Th2 differentiation, thereby shifting the Th1/Th2 balance toward Th2.
Negative_regulation (inhibition) of Th1 in Th1 cell associated with inflammation and rheumatoid arthritis
15) Confidence 0.20 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC2833981 Disease Relevance 0.42 Pain Relevance 0.37
It has been described that T cell function in patients with peritonitis had decreased Th1 function, without increased Th2 response, and furthermore T cell proliferation and cytokine secretion correlated with mortality [30].
Negative_regulation (decreased) of Th1 in T cell associated with peritonitis and cytokine
16) Confidence 0.15 Published 2005 Journal BMC Immunol Section Body Doc Link PMC546205 Disease Relevance 0.47 Pain Relevance 0.09
However, Th1 cytokines were not reduced, and IFN-?
Negative_regulation (reduced) of Th1 associated with cytokine
17) Confidence 0.14 Published 2010 Journal BMC Immunol Section Body Doc Link PMC2858026 Disease Relevance 0.96 Pain Relevance 0.44
Our results clearly show that rHuIL-10 can suppress clinical EAN, and this suppression is associated with downregulation of TH1 responses and macrophage function and upregulated TH2 responses.
Negative_regulation (downregulation) of TH1 in macrophage associated with neuritis
18) Confidence 0.13 Published 1997 Journal Clin. Immunol. Immunopathol. Section Abstract Doc Link 9143372 Disease Relevance 0.87 Pain Relevance 0.81
There was a significant decrease in Th1-type/Th2-type ratios between CIN II and CIN III for IL-12/IL-4 and IL-12/IL-10.
Negative_regulation (decrease) of Th1
19) Confidence 0.11 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC2220028 Disease Relevance 0.72 Pain Relevance 0.29
This Th2 type cytokine is well known as a downregulator of the above-mentioned Th1 mediators in human macrophages [35].
Negative_regulation (downregulator) of Th1 in macrophages associated with cytokine
20) Confidence 0.09 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2374451 Disease Relevance 0.57 Pain Relevance 0.38

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