INT6931

Context Info Confidence 0.24 First Reported 1992 Last Reported 2008 Negated 0 Speculated 0 Reported most in Abstract Documents 2 Total Number 2 Disease Relevance 0.92 Pain Relevance 1.92

plasma membrane (Oprk1, Pdyn) signal transduction (Oprk1) signal transducer activity (Oprk1)

Oprk1 (Mus musculus) Pdyn (Mus musculus)

Pain Link Frequency Relevance Heat Opioid 15 100.00 Dynorphin 4 100.00 opioid receptor 21 99.96 fortral 1 96.16 alcohol 36 94.56 addiction 24 93.84 narcan 6 62.68 withdrawal 1 44.12 Nucleus accumbens 3 38.80 Dopamine 3 35.08

Disease Link Frequency Relevance Heat Alcohol Addiction 35 93.84 Opiate Addiction 1 85.40 Lymphatic System Cancer 3 80.48 Convulsion 1 44.80 Sprains And Strains 2 5.00 Drug Dependence 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The involvement of genes encoding both an opioid receptor (OPRK1) and its ligand (PDYN) makes biological sense, indicating that variations in signaling through this system, by varying either the ligand or receptor, affect alcohol consumption and alcohol dependence.

OPRK1 Binding (ligand) of PDYN associated with addiction, opioid receptor and alcohol

1) Confidence 0.24 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.76 Pain Relevance 0.91

Based on its high affinity for U69,593, alpha-neo-endorphin, and dynorphin B, the kappa opioid binding site on R1.1 cell membranes belongs to the kappa 1b subtype.

kappa opioid binding site Binding (affinity) of dynorphin B associated with dynorphin and opioid

2) Confidence 0.09 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1335414 Disease Relevance 0.16 Pain Relevance 1.01

General Comments

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