INT6931

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Context Info
Confidence 0.24
First Reported 1992
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.92
Pain Relevance 1.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprk1, Pdyn) signal transduction (Oprk1) signal transducer activity (Oprk1)
Oprk1 (Mus musculus)
Pdyn (Mus musculus)
Pain Link Frequency Relevance Heat
Opioid 15 100.00 Very High Very High Very High
Dynorphin 4 100.00 Very High Very High Very High
opioid receptor 21 99.96 Very High Very High Very High
fortral 1 96.16 Very High Very High Very High
alcohol 36 94.56 High High
addiction 24 93.84 High High
narcan 6 62.68 Quite High
withdrawal 1 44.12 Quite Low
Nucleus accumbens 3 38.80 Quite Low
Dopamine 3 35.08 Quite Low
Disease Link Frequency Relevance Heat
Alcohol Addiction 35 93.84 High High
Opiate Addiction 1 85.40 High High
Lymphatic System Cancer 3 80.48 Quite High
Convulsion 1 44.80 Quite Low
Sprains And Strains 2 5.00 Very Low Very Low Very Low
Drug Dependence 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of genes encoding both an opioid receptor (OPRK1) and its ligand (PDYN) makes biological sense, indicating that variations in signaling through this system, by varying either the ligand or receptor, affect alcohol consumption and alcohol dependence.
OPRK1 Binding (ligand) of PDYN associated with addiction, opioid receptor and alcohol
1) Confidence 0.24 Published 2008 Journal Human Molecular Genetics Section Body Doc Link PMC2405904 Disease Relevance 0.76 Pain Relevance 0.91
Based on its high affinity for U69,593, alpha-neo-endorphin, and dynorphin B, the kappa opioid binding site on R1.1 cell membranes belongs to the kappa 1b subtype.
kappa opioid binding site Binding (affinity) of dynorphin B associated with dynorphin and opioid
2) Confidence 0.09 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1335414 Disease Relevance 0.16 Pain Relevance 1.01

General Comments

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