INT69311

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Context Info
Confidence 0.78
First Reported 1997
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 31
Total Number 31
Disease Relevance 15.54
Pain Relevance 14.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Scn10a) plasma membrane (Scn10a) transmembrane transport (Scn10a)
Anatomy Link Frequency
DRG 4
neurons 3
neuronal 2
sensory neuron 2
tail 1
Scn10a (Mus musculus)
Pain Link Frequency Relevance Heat
tetrodotoxin 88 100.00 Very High Very High Very High
sodium channel 68 100.00 Very High Very High Very High
nav1.8 22 100.00 Very High Very High Very High
Root ganglion neuron 2 99.98 Very High Very High Very High
c fibre 63 99.88 Very High Very High Very High
dorsal root ganglion 87 99.86 Very High Very High Very High
Arthritis 24 99.80 Very High Very High Very High
nociceptor 86 99.78 Very High Very High Very High
Neuropeptide 30 99.74 Very High Very High Very High
Inflammation 127 99.64 Very High Very High Very High
Disease Link Frequency Relevance Heat
Targeted Disruption 496 100.00 Very High Very High Very High
Ganglion Cysts 161 99.86 Very High Very High Very High
Experimental Arthritis 7 99.80 Very High Very High Very High
INFLAMMATION 127 99.64 Very High Very High Very High
Nociception 70 99.40 Very High Very High Very High
Pain 195 99.22 Very High Very High Very High
Sprains And Strains 361 98.60 Very High Very High Very High
Synovitis 5 97.72 Very High Very High Very High
Neuroblastoma 3 97.60 Very High Very High Very High
Hyperalgesia 17 96.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These data show that SNS is involved in pain pathways and suggest that blockade of SNS expression or function may produce analgesia without side effects.
Gene_expression (expression) of SNS associated with pain and analgesia
1) Confidence 0.78 Published 1999 Journal Nat. Neurosci. Section Abstract Doc Link 10448219 Disease Relevance 0.51 Pain Relevance 1.36
Scn10a, the gene for the TTX-R Na+ channel Nav1.8, was expressed mostly in neuronal profiles of small and medium size in naïve mice.
Gene_expression (expressed) of Scn10a in neuronal associated with nav1.8
2) Confidence 0.73 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.13 Pain Relevance 0.64
These results provide the basis for an evolutionary comparison of sodium channels, the construction and analysis of a mouse SNS null mutant as a direct approach to understanding the biological function of SNS, and the identification of regulatory elements that are responsible for the tissue- and cell-specific expression of SNS.
Gene_expression (expression) of SNS associated with sodium channel
3) Confidence 0.68 Published 1997 Journal Genomics Section Abstract Doc Link 9143495 Disease Relevance 0.05 Pain Relevance 0.37
Here we describe the generation of transgenic mouse lines which express Cre recombinase selectively in sensory ganglia using promoter elements of the Na(v)1.8 gene (Scn10a).
Gene_expression (express) of Scn10a in ganglia associated with targeted disruption
4) Confidence 0.65 Published 2004 Journal Genesis Section Abstract Doc Link 15048809 Disease Relevance 0.51 Pain Relevance 0.22
We hypothesized that the t-toxin might have a stronger effect on IB4+ve nociceptors since the Scn10a gene promoter was used to genetically drive expression of the t-toxin.
Gene_expression (expression) of Scn10a in nociceptors associated with nociceptor
5) Confidence 0.64 Published 2010 Journal The Journal of Physiology Section Body Doc Link PMC2887988 Disease Relevance 0 Pain Relevance 0.95
SNL surgery induced down-regulation in the L5DRG in all strains (Fig. 1; p < 0.05) with no marked change in the size distribution of Scn10a -expressing neuronal profiles.
Gene_expression (expressing) of Scn10a in neuronal associated with eae and sprains and strains
6) Confidence 0.56 Published 2009 Journal Mol Pain Section Body Doc Link PMC2649910 Disease Relevance 1.28 Pain Relevance 0.61
Genotyping was done on mouse genomic tail DNA using primers: for sense strand 5'-ATCTCTTCCTTGGCTGGGTCTTTGCTTCGCTCG-3' and for anti-sense 5'-GGGTTATTGAATATGATCGGAATTCCTCGACT-3' to detect GABAB1 flox allele, and for sense strand 5'-GAAAGCAGCCATGTCCAATTTACTGACCGTAC-3' and for anti-sense strand 5'-GCGCGCCTGAAGATATAGAAGA-3' to detect SNS-Cre transgene expression.
Gene_expression (expression) of SNS-Cre in tail
7) Confidence 0.56 Published 2009 Journal Mol Pain Section Body Doc Link PMC2785766 Disease Relevance 0.24 Pain Relevance 0.20
Nociceptive dorsal root ganglion neurons express sensory neuron-specific tetrodotoxin (TTX)-resistant voltage-gated sodium channel(SNS).
Gene_expression (express) of SNS in sensory neuron associated with ganglion cysts, nociception, tetrodotoxin, sodium channel and root ganglion neuron
8) Confidence 0.53 Published 2001 Journal Nippon Rinsho Section Abstract Doc Link 11554037 Disease Relevance 0.63 Pain Relevance 0.89
Two mRNAs that are predicted to encode TTX-R sodium channels, SNS and NaN, are preferentially expressed in C-type DRG cells.
Gene_expression (expressed) of SNS in DRG associated with dorsal root ganglion and sodium channel
9) Confidence 0.50 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10594087 Disease Relevance 0.47 Pain Relevance 0.31
alpha-SNS produces the slow TTX-resistant sodium current in large cutaneous afferent DRG neurons.
Gene_expression (produces) of SNS in neurons
10) Confidence 0.50 Published 2000 Journal J. Neurophysiol. Section Title Doc Link 10938298 Disease Relevance 0.33 Pain Relevance 0.51
All SNS expressing A-fiber cells are Trk-A positive and many express the vanilloid-like receptor VRL1.
Gene_expression (expressing) of SNS
11) Confidence 0.34 Published 2000 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 10845770 Disease Relevance 0.45 Pain Relevance 0.96
Diversity of expression of the sensory neuron-specific TTX-resistant voltage-gated sodium ion channels SNS and SNS2.
Gene_expression (expression) of SNS in sensory neuron associated with neuropeptide
12) Confidence 0.34 Published 2000 Journal Mol. Cell. Neurosci. Section Title Doc Link 10845770 Disease Relevance 0.40 Pain Relevance 1.05
SNS and SNS2 are found both in NGF-responsive and GDNF-responsive C-fibers and many of these cells also express the capsaicin receptor VR1.
Gene_expression (found) of SNS associated with c fibre and qutenza
13) Confidence 0.30 Published 2000 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 10845770 Disease Relevance 0.44 Pain Relevance 1.00
Within 20 min of DHPG treatment, APP levels in WT SNs approached those seen in unstimulated KO SNs (Figure 4).
Gene_expression (levels) of SNs associated with targeted disruption
14) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.74 Pain Relevance 0
APP mRNA was readily detected in anti-FMRP pellets in untreated WT SNs (Figure 6A).
Gene_expression (detected) of SNs
15) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.24 Pain Relevance 0
Aliquots of SNs were collected at 5, 10, and 20 min after DHPG treatment, quenched with an equal volume of 2× SDS sample buffer (8% SDS, 24% glycerol, 100 mM Tris [pH 6.8], 4% ?
Gene_expression (Aliquots) of SNs
16) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0 Pain Relevance 0
Within 20 min of DHPG treatment, APP levels in WT SNs approached those seen in unstimulated KO SNs (Figure 4).
Gene_expression (approached) of SNs associated with targeted disruption
17) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.75 Pain Relevance 0
Contrary to a previous report utilizing a different protocol for the preparation of SNs [26], APP mRNA is present in SNs, and reverse transcription (RT)–PCR revealed that the message was brought down with specific, but not control, antisera in cortical lysates as well as SNs (unpublished data).
Gene_expression (present) of SNs
18) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.06 Pain Relevance 0
Thus, APP mRNA decays with comparable kinetics in SNs and mammalian cells.


Gene_expression (decays) of SNs
19) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.37 Pain Relevance 0.07
DHPG was dissolved in 1× stimulation buffer immediately prior to use and added to the SNs (100 ?
Gene_expression (added) of SNs
20) Confidence 0.28 Published 2007 Journal PLoS Biology Section Body Doc Link PMC1808499 Disease Relevance 0.20 Pain Relevance 0.09

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