INT69321

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Context Info
Confidence 0.61
First Reported 1997
Last Reported 2010
Negated 4
Speculated 5
Reported most in Abstract
Documents 27
Total Number 32
Disease Relevance 13.27
Pain Relevance 9.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (PTGS2) endoplasmic reticulum (PTGS2) enzyme binding (PTGS2)
protein complex (PTGS2) cytoplasm (PTGS2) lipid binding (PTGS2)
Anatomy Link Frequency
monocytes 10
RAW 264 6
blood 3
granulocytes 3
chondrocytes 2
PTGS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 39 100.00 Very High Very High Very High
COX2 25 100.00 Very High Very High Very High
Dismenorea 6 100.00 Very High Very High Very High
Osteoarthritis 4 100.00 Very High Very High Very High
cOX1 3 100.00 Very High Very High Very High
cINOD 53 99.98 Very High Very High Very High
cytokine 12 99.90 Very High Very High Very High
Inflammation 87 99.40 Very High Very High Very High
Arthritis 8 97.88 Very High Very High Very High
Pain 8 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 33 100.00 Very High Very High Very High
Colon Cancer 10 100.00 Very High Very High Very High
Dysmenorrhea 6 100.00 Very High Very High Very High
Osteoarthritis 5 100.00 Very High Very High Very High
Necrosis 4 100.00 Very High Very High Very High
INFLAMMATION 123 99.40 Very High Very High Very High
Disease 35 99.36 Very High Very High Very High
Urological Neuroanatomy 4 99.04 Very High Very High Very High
Arthritis 8 97.88 Very High Very High Very High
Apoptosis 3 97.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Using freshly elutriated human monocytes, we examined the effect on PGHS-2 expression of certain cytokine-suppressive anti-inflammatory drugs such as SK&F 86002.
Spec (examined) Regulation (effect) of Gene_expression (expression) of PGHS-2 in monocytes associated with inflammation, cinod and cytokine
1) Confidence 0.61 Published 1997 Journal J. Immunol. Section Abstract Doc Link 9144511 Disease Relevance 0.10 Pain Relevance 0.18
Expression of PTGS2 is tightly controlled, with basal levels low to nonexistent in most tissue types.
Regulation (controlled) of Gene_expression (Expression) of PTGS2
2) Confidence 0.55 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC1851394 Disease Relevance 1.14 Pain Relevance 0.29
Exogenous prostaglandin E(2) (IC(50)<5 nM) inhibited endotoxin-induced TNFalpha mRNA and protein while, up to 1 microM, it did not significantly affect cyclooxygenase-2 mRNA expression.
Neg (not) Regulation (affect) of Gene_expression (expression) of cyclooxygenase-2 mRNA
3) Confidence 0.48 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.18 Pain Relevance 0.19
Cyclooxygenase inhibition in human monocytes increases endotoxin-induced TNF alpha without affecting cyclooxygenase-2 expression.
Neg (without) Regulation (affecting) of Gene_expression (expression) of cyclooxygenase-2 in monocytes associated with cox2
4) Confidence 0.48 Published 2004 Journal Eur. J. Pharmacol. Section Title Doc Link 15464057 Disease Relevance 0.19 Pain Relevance 0.29
A few days after starting treatment, epithelial proliferation and increased mucosal blood flow, partly dependent on cyclooxygenase-2 and nitric oxide expression, compensates for the damaging process.
Regulation (dependent) of Gene_expression (expression) of cyclooxygenase-2 in blood
5) Confidence 0.45 Published 2004 Journal Gastroenterol. Clin. Biol. Section Abstract Doc Link 15366671 Disease Relevance 0.86 Pain Relevance 0.55
Cyclooxygenase-2 expression in lipopolysaccharide-stimulated human monocytes is modulated by cyclic AMP, prostaglandin E(2), and nonsteroidal anti-inflammatory drugs.
Regulation (modulated) of Gene_expression (expression) of Cyclooxygenase-2 in monocytes associated with inflammation, cinod and cox1
6) Confidence 0.40 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Title Doc Link 11095985 Disease Relevance 0.18 Pain Relevance 0.32
Human endotoxin-stimulated adherent monocytes were used in order to determine whether or not NSAIDs influence cyclooxygenase-2 and/or tumor necrosis factor (TNF)alpha expression within the range of inhibitor concentrations that are required to suppress prostaglandin biosynthesis.
Neg (not) Spec (whether) Regulation (influence) of Gene_expression (expression) of cyclooxygenase-2 in monocytes associated with necrosis, cancer and cinod
7) Confidence 0.35 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15464057 Disease Relevance 0.20 Pain Relevance 0.13
Our comparison study shows that it is unlikely, that identical active site constellations are responsible for PGH2 specificity in these seven cases.
Regulation (responsible) of Gene_expression (specificity) of PGH2
8) Confidence 0.35 Published 2010 Journal BMC Bioinformatics Section Body Doc Link PMC3009524 Disease Relevance 0 Pain Relevance 0
OBJECTIVE: To evaluate the in vitro effects of diacerhein, a new drug for the treatment of osteoarthritis (OA), and its active metabolite, rhein, on the production of nitric oxide (NO), prostaglandin (PGE2), cyclooxygenase-2 (COX-2), as well as the production and expression of the inducible nitric oxide synthase (iNOS) in human OA chondrocytes.
Regulation (effects) of Gene_expression (production) of cyclooxygenase-2 in chondrocytes associated with osteoarthritis
9) Confidence 0.34 Published 1998 Journal J. Rheumatol. Section Abstract Doc Link 9858439 Disease Relevance 0.37 Pain Relevance 0.23
Using human blood monocytes (for determination of cyclooxygenase-2 (COX-2) mRNA by RT-PCR) and human whole blood (for prostanoid determination), the present study investigates the influence of the second messenger cAMP on lipopolysaccharide (LPS)-induced COX-2 expression with particular emphasis on the role of prostaglandin E(2) (PGE(2)) in this process.
Spec (investigates) Regulation (influence) of in monocytes Gene_expression (expression) of cyclooxygenase-2 in blood
10) Confidence 0.29 Published 2000 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 11095985 Disease Relevance 0.16 Pain Relevance 0.13
However, the role of cyclooxygenase-2 expression in colorectal cancer has not yet been fully established.
Regulation (role) of Gene_expression (expression) of cyclooxygenase-2 associated with colon cancer
11) Confidence 0.27 Published 2002 Journal Dis. Colon Rectum Section Abstract Doc Link 11786771 Disease Relevance 0.46 Pain Relevance 0.09
Cyclooxygenase 2 expression tested in the same experimental conditions was modulated in monocytes and granulocytes similarly to mPGES-1.
Regulation (modulated) of Gene_expression (expression) of Cyclooxygenase 2 in granulocytes associated with cox2
12) Confidence 0.26 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.39 Pain Relevance 0.36
We further examine the evidence for independent signaling by PGHS-1 and PGHS-2, and the complex mechanisms for regulation of PGHS-2 gene expression.
Regulation (regulation) of Gene_expression (expression) of PGHS-2
13) Confidence 0.25 Published 2000 Journal Annu. Rev. Biochem. Section Abstract Doc Link 10966456 Disease Relevance 0.48 Pain Relevance 0.47
Recent studies have also shown that certain flavonoids, especially flavone derivatives, express their anti-inflammatory activity at least in part by modulation of proinflammatory gene expression such as cyclooxygenase-2, inducible nitric oxide synthase, and several pivotal cytokines.
Regulation (modulation) of Gene_expression (expression) of cyclooxygenase-2 associated with inflammation and cytokine
14) Confidence 0.24 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 15539763 Disease Relevance 0.63 Pain Relevance 0.41
We found up-regulation of cyclooxygenase-2 expression in Alzheimer's disease frontal cortex.
Regulation (regulation) of Gene_expression (expression) of cyclooxygenase-2 in frontal cortex associated with urological neuroanatomy and disease
15) Confidence 0.24 Published 1998 Journal Neuroscience Section Abstract Doc Link 9740394 Disease Relevance 1.25 Pain Relevance 0.18
Excitotoxic lesions cause up-regulation of cyclooxygenase-2 expression coincident with the onset of expression of markers of apoptosis; cyclooxygenase-2 thus represents a possible target of non-steroidal anti-inflammatory drug action in neurodegenerative mechanisms.
Regulation (regulation) of Gene_expression (expression) of cyclooxygenase-2 associated with inflammation, neurodegenerative disease and apoptosis
16) Confidence 0.24 Published 1998 Journal Neuroscience Section Abstract Doc Link 9740394 Disease Relevance 1.15 Pain Relevance 0.21
Expression of cyclooxygenase isoforms 1 and 2 remained unaffected, and COX-inhibitors did not antagonize HO-1 induction by PPIs.
Neg (unaffected) Regulation (unaffected) of Gene_expression (Expression) of cyclooxygenase isoforms 1 and 2
17) Confidence 0.19 Published 2006 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 16712795 Disease Relevance 0.17 Pain Relevance 0.07
Cyclooxygenase 2 expression tested in the same experimental conditions was modulated in monocytes and granulocytes similarly to mPGES-1.
Regulation (modulated) of in monocytes Gene_expression (expression) of Cyclooxygenase 2 in granulocytes associated with cox2
18) Confidence 0.09 Published 2007 Journal J. Leukoc. Biol. Section Abstract Doc Link 17505022 Disease Relevance 0.39 Pain Relevance 0.36
Cyclooxygenase-2 expression was found here to be significantly amplified by PAR2 activation.
Regulation (amplified) of Gene_expression (expression) of Cyclooxygenase-2
19) Confidence 0.09 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2970545 Disease Relevance 1.41 Pain Relevance 0.71
Phenylpropanoids may act as nonsteroidal anti-inflammatory drug (NSAID)-like compounds. 4-cis, 8-cis-Bis (4-hydroxy-3-methoxyphenyl)-3, 7-dioxabicyclo-[3.3.0]octane-2,6-dione (bis-FA, compound 2), a dimer of ferulic acid, was synthesized from ferulic acid (1), and its effect on lipopolysaccharide (LPS)-stimulated cyclooxygenase-2 (COX-2) expression in RAW 264.7 cells was compared with those of the parent ferulic acid (1) and of iso-ferulic acid (3-hydroxy-4-methoxycinnamic acid) (3).
Regulation (effect) of Gene_expression (expression) of cyclooxygenase-2 in RAW 264 associated with inflammation and cinod
20) Confidence 0.08 Published 2005 Journal In Vivo Section Abstract Doc Link 16097437 Disease Relevance 0.16 Pain Relevance 0.23

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