INT6933

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Context Info
Confidence 0.10
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 15
Total Number 16
Disease Relevance 4.77
Pain Relevance 6.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
NG108-15 1
embryonic kidney 1
ANTXRL (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 27 100.00 Very High Very High Very High
narcan 6 100.00 Very High Very High Very High
Opioid 12 99.36 Very High Very High Very High
agonist 11 99.32 Very High Very High Very High
addiction 5 99.14 Very High Very High Very High
tolerance 11 98.92 Very High Very High Very High
Enkephalin 7 98.40 Very High Very High Very High
antagonist 4 98.28 Very High Very High Very High
bradykinin 3 97.36 Very High Very High Very High
substance P 4 97.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Bordatella Infection 37 100.00 Very High Very High Very High
Glioma 3 99.62 Very High Very High Very High
Hypotension 5 99.60 Very High Very High Very High
Hypertension 3 94.00 High High
Diarrhoea 1 89.84 High High
Vomiting 2 88.96 High High
Abdominal Pain 1 87.28 High High
Neuroblastoma 2 73.88 Quite High
Increased Venous Pressure Under Development 1 72.56 Quite High
Sleep Disorders 1 71.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the role of G(i1) and G(i3) in opioid-induced AC supersensitization, pertussis toxin-resistant mutants of Galpha(i1) and Galpha(i3) (Galpha(i1)CG and Galpha(i3)CG) were stably co-expressed with different opioid receptors (mu, delta or kappa) in human embryonic kidney (HEK 293) cells.
Gene_expression (resistant) of pertussis toxin in embryonic kidney associated with bordatella infection, opioid receptor and opioid
1) Confidence 0.10 Published 2001 Journal Neurosci. Lett. Section Abstract Doc Link 11166929 Disease Relevance 0.42 Pain Relevance 0.46
Effects of pertussis toxin on behavioural responses of guinea-pigs to centrally administered substance P, quinpirole, carbachol, U-50,488H, morphine and morphine withdrawal.
Gene_expression (Effects) of pertussis toxin associated with bordatella infection, narcan, withdrawal, morphine and substance p
2) Confidence 0.08 Published 1993 Journal Eur. J. Pharmacol. Section Title Doc Link 7680319 Disease Relevance 0.26 Pain Relevance 0.99
Using Western blotting, we have found that the pertussis toxin-resistant G-proteins alpha(q), alpha(11) and alpha(2), and pertussis toxin-sensitive alpha(i1), alpha(i2), and alpha(i3) are expressed in these cells.
Gene_expression (expressed) of pertussis toxin-sensitive associated with bordatella infection
3) Confidence 0.05 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8713998 Disease Relevance 0.52 Pain Relevance 0.15
Pretreatment of cells with pertussis toxin did not inhibit pentoxifylline-induced decrease in F-actin, suggesting pentoxifylline does not act through pertussis toxin-sensitive G-proteins.
Gene_expression (Pretreatment) of pertussis toxin associated with bordatella infection
4) Confidence 0.04 Published 1988 Journal J. Cell. Physiol. Section Abstract Doc Link 2848043 Disease Relevance 0.27 Pain Relevance 0.07
Our data suggest that two distinct types of G-proteins are involved in the oxytocin response: one most probably a member of the Gq family (pertussis toxin-resistant) and another of the Gi family (pertussis toxin-sensitive).
Gene_expression (resistant) of pertussis toxin associated with bordatella infection
5) Confidence 0.04 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8713998 Disease Relevance 0.52 Pain Relevance 0.10
Using Western blotting, we have found that the pertussis toxin-resistant G-proteins alpha(q), alpha(11) and alpha(2), and pertussis toxin-sensitive alpha(i1), alpha(i2), and alpha(i3) are expressed in these cells.
Gene_expression (expressed) of pertussis toxin associated with bordatella infection
6) Confidence 0.04 Published 1995 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 8713998 Disease Relevance 0.53 Pain Relevance 0.16
These results, taking the molecular weight of covalently bound beta-endorphin (3.6 kDa) into consideration, suggest that the delta-opioid receptor in NG108-15 cell membrane is a 25 kDa protein which is coupled to pertussis toxin-sensitive guanosine triphosphate-binding proteins (G-proteins).
Gene_expression (coupled) of pertussis toxin in NG108-15 associated with bordatella infection and opioid receptor
7) Confidence 0.03 Published 1992 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1335416 Disease Relevance 0.32 Pain Relevance 0.28
The OXA-induced initial current was partially pertussis toxin (PTX) sensitive and partially PTX insensitive, whereas the OXA-suppressed current was PTX insensitive.
Gene_expression (sensitive) of pertussis toxin associated with bordatella infection
8) Confidence 0.03 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12702704 Disease Relevance 0.10 Pain Relevance 0.34
Pre-incubation of trophoblastic cells with pertussis toxin (PTX) did not affect the EKC-induced 45Ca2+ influx, suggesting that this placental opiate effect is not coupled with PTX-sensitive G proteins.
Gene_expression (Pre-incubation) of pertussis toxin associated with bordatella infection and opiate
9) Confidence 0.01 Published 1993 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 7684340 Disease Relevance 0.10 Pain Relevance 0.81
Okadaic acid (OA), a marine toxin produced by dinoflagellates, can accumulate in various bivalve molluscs.
Gene_expression (produced) of toxin
10) Confidence 0.00 Published 2010 Journal Toxicon Section Abstract Doc Link 20026154 Disease Relevance 0.35 Pain Relevance 0.09
Pertussis toxin (PTX)-insensitive mutants of Galpha(i/o) proteins expressed in C6mu cells were used to examine the hypothesis that there are agonist-specific conformational states of the mu-opioid receptor with coupling preferences to different Galpha(i/o) subtypes, as measured by the degree of stimulation of [(35)S]guanosine 5'-O-(3-thio)triphosphate (GTPgammaS) binding.
Gene_expression (expressed) of Pertussis toxin associated with bordatella infection, agonist and opioid receptor
11) Confidence 0.00 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16436499 Disease Relevance 0.17 Pain Relevance 0.34
We investigated the effect of pertussis toxin (PTX) on hypotensive response induced by acetylcholine (ACh) and bradykinin (BK) and on noradrenaline (NA)-induced pressor response in spontaneously hypertensive rats (SHR).
Spec (investigated) Gene_expression (effect) of pertussis toxin associated with bordatella infection, hypertension, hypotension, noradrenaline and bradykinin
12) Confidence 0.00 Published 2008 Journal Physiol Res Section Abstract Doc Link 18412515 Disease Relevance 0.57 Pain Relevance 0.27
To determine the intracellular signal transduction pathway responsible for the development of tolerance/dependence, the ability of Gzalpha to substitute for pertussis toxin (PTX)-sensitive G proteins in mediating adenylyl cyclase (AC) supersensitivity was examined in the presence of defined AC isoforms.
Gene_expression (sensitive) of pertussis toxin associated with addiction, bordatella infection and tolerance
13) Confidence 0.00 Published 2002 Journal J. Neurochem. Section Abstract Doc Link 12421353 Disease Relevance 0.10 Pain Relevance 0.55
Down-regulation of 6 opioid receptors was not observed in cells exposed for 24 h to pertussis toxin (PTX) and then treated for 24 h with 100 nM delta9-THC.
Gene_expression (exposed) of pertussis toxin associated with bordatella infection and opioid receptor
14) Confidence 0.00 Published 1998 Journal Life Sci. Section Abstract Doc Link 9771917 Disease Relevance 0.25 Pain Relevance 0.59
The involvement of pertussis toxin (PTX)-sensitive G proteins in the actions of LHRH was studied.
Gene_expression (sensitive) of pertussis toxin associated with bordatella infection
15) Confidence 0.00 Published 1997 Journal Neuropeptides Section Abstract Doc Link 9179862 Disease Relevance 0.10 Pain Relevance 0.82
C6 glioma cells were stably transfected with mu-opioid receptor and pertussis toxin (PTX)-insensitive Galpha(o) that was either sensitive or insensitive to endogenous RGS proteins.
Gene_expression (transfected) of pertussis toxin associated with bordatella infection, opioid receptor and glioma
16) Confidence 0.00 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15383633 Disease Relevance 0.20 Pain Relevance 0.82

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